Detection of early-life failures in high-K metal-gate transistors and ultra low-K inter-metal dielectrics

Kim, Young Moon; Seomun, Jun; Kim, Hyung-Ock; Do, Kyung-Tae; Choi, Jong Seob; Kim, Kee Sup; Sauer, Matthias; Becker, Bernd; Mitra, Subhasish

doi:10.1109/cicc.2013.6658544

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…118 Other studies have demonstrated the optogenetic activation of bulk immune cells, including Tcells and dendritic cells, using wide-field illumination and calcium actuators. 119,120 The spatiotemporal control of T-cells in the tumor region is crucial for effective cancer therapy. Recently, mechanogenetically engineered CAR-T systems have been mechanically sensitized to guide and control CAR-T cell activities spatiotemporally.…”

Section: T-cells the Ability Of T-cells To Recognize And Destroy Canc...mentioning

confidence: 99%

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Mechanobiological Strategies to Augment Cancer Treatment

Kumari,

Veena,

Luha

et al. 2023

ACS Omega

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Cancer cells exhibit aberrant extracellular matrix mechanosensing due to the altered expression of mechanosensory cytoskeletal proteins. Such aberrant mechanosensing of the tumor microenvironment (TME) by cancer cells is associated with disease development and progression. In addition, recent studies show that such mechanosensing changes the mechanobiological properties of cells, and in turn cells become susceptible to mechanical perturbations. Due to an increasing understanding of cell biomechanics and cellular machinery, several approaches have emerged to target the mechanobiological properties of cancer cells and cancer-associated cells to inhibit cancer growth and progression. In this Perspective, we summarize the progress in developing mechano-based approaches to target cancer by interfering with the cellular mechanosensing machinery and overall TME.

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Section: T-cells the Ability Of T-cells To Recognize And Destroy Canc...mentioning

confidence: 99%

“…. (e) Targeting cells associated with tumor-associated T-cells,114,119 dendritic cells,130,132,138 tumor-associated macrophages,149 and cancer-associated fibroblasts 79. (f) Targeting mechanosensitive channels, mechanosensors, and mechanotransducers of the cancer cell, including TRPV4,55,89 Piezo1,55,68 Rho/ROCK, 10,55 YAP/TAZ, 56−59 and TGF-β 33,35,40,81.…”

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confidence: 99%

Mechanobiological Strategies to Augment Cancer Treatment

Kumari,

Veena,

Luha

et al. 2023

ACS Omega

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“…[112] Other studies have demonstrated optogenetic activation of bulk immune cells, including T-cells and dendritic cells, using wide-field illumination and calcium actuators. [113][114][115] The spatiotemporal control of T-cells in the tumor region is crucial for effective cancer therapy. Recently, mechano-genetically engineered CAR-T systems have been mechanically sensitized to guide and control CAR-T cell activities spatiotemporally.…”

Section: T Cellsmentioning

confidence: 99%

“…Schematic representation of mechanobiology-based therapies. Targeting cancer cells by mechanical perturbations like (a) shock wave [61-63,76] (b) mechanical stretch [63,64,138,139] (c) High-Intensity Ultrasound Frequency [40,72,125-127](d) Low-Intensity Pulsed Ultrasound [67,96-99](e) targeting cells associated with tumors associated T-cells, [107,112] dendritic cells,[121,123,126] tumor-associated macrophages,[136] cancer-associated fibroblasts[147] and (f) targeting mechanosensitive channels, mechanosensors and mechanotransducers of the cancer cell including TRPV4,[50,85] Piezo1,[49,63,105,113,114] Rho/ROCK,[10,146] YAP/TAZ[51][52][53][54][55] and TGF-β[28,30,35,77].…”

mentioning

confidence: 99%

Harnessing Mechanical Forces for Cancer Treatment

Kumari,

Veena,

Luha

et al. 2023

Preprint

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Cancer cells exhibit aberrant extracellular matrix mechanosensing due to altered expression of mechanosensory cytoskeletal proteins. Aberrant mechanosensing of the tumor microenvironment (TME) by cancer cells has been shown to be associated with cancer development and progression. Recent studies show that altered mechanosensing changes the mechanobiological properties of cells, and, in turn, cells become susceptible to mechanical perturbations. Due to an increasing understanding of cell biomechanics and cellular machinery, several approaches have emerged to target the mechanobiological properties of cancer cells and cancer-associated cells to inhibit cancer growth and progression. In this review, we summarize the progress that happened in the development of mechano-based approaches to target cancer by interfering with the cellular mechanosensing machinery and overall TME.

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