Detection of EBV Infection and Gene Expression in Oral Cancer from Patients in Taiwan by Microarray Analysis

Yen, Ching‐Yu; Lu, Min-Chi; Tzeng, Ching‐Cherng; Huang, Jui Chien; Chang, Hong-Po; Chen, Ruey-Shyang; Liu, Shyun-Yeu; Liu, Shih‐Tung; Shieh, Biehuoy; Li, Ching

doi:10.1155/2009/904589

Cited by 35 publications

(32 citation statements)

References 56 publications

(64 reference statements)

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“…HSV nucleic acids have been found in lip cancer (39), antibody levels to HSV-1 and -2 are higher in oral cancer patients when compared with controls, and HSV seropositivity together with smoking has been associated with increased cancer risk (27). Epstein-Barr virus has also been implicated in oral cancer but the evidence thus far is controversial (40)(41)(42)(43)(44)(45).…”

Section: -Virus Infections • Human Papillomavirus Infectionsmentioning

confidence: 99%

Oral cancer aetiopathogenesis; past, present and future aspects

Scully¹

2011

Med Oral

101

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Oral cancer appears to be increasing in incidence, and mortality has hardly improved over the past 25 years. Better understanding of the aetiopathogenesis should lead to more accurate and earlier diagnosis and more effective treatments with fewer adverse effects. Cancer is the result of DNA mutations arising spontaneously and from the action of various mutagens, especially in tobacco and alcohol. A sequence of genetic changes leads eventually to loss of growth control and autonomy. Countering these changes are mechanisms to metabolise carcinogens, repair DNA damage, control growth, and defend against cancer. Cancer is a consequence of an interaction of these many factors. Diagnosis is increasingly aided by detection of cellular and now molecular changes. Treatment is increasingly looking towards chemotherapy and now gene therapy. However, there is no doubt that prevention is the most important aspect, particularly patient education and the reduction of lifestyle risk habits and environmental factors.

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Section: -Virus Infections • Human Papillomavirus Infectionsmentioning

confidence: 99%

Oral cancer aetiopathogenesis; past, present and future aspects

Scully¹

2011

Med Oral

101

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“…By using EBV chips, Yen et al 51 have demonstrated an increased sensitivity of EBV detection rate in oral cancer cells as compared with traditional molecular assays (from 15–77% to 82·5%).…”

Section: Pathological and Virological Techniques: Clinical Applicationsmentioning

confidence: 99%

Cancers related to viral agents that have a direct role in carcinogenesis: pathological and diagnostic techniques

Carbone

Paoli

2012

J Clin Pathol

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The International Agency for Research on Cancer has recently reassessed the carcinogenicity of the biological agents classified as ‘carcinogenic to humans’. Among the biological agents having a direct role in carcinogenesis, Epstein-Barr virus, Kaposi's sarcoma-associated herpes virus and human papillomavirus contribute to a variety of malignancies worldwide in humans including nasopharyngeal carcinoma, several types of lymphomas, genital tract carcinomas and Kaposi's sarcoma. The authors review the current knowledge on cancers that have been attributed to Epstein-Barr virus, Kaposi's sarcoma-associated herpes virus and human papillomavirus looking at the pathological classification of these cancers and description of the implicated viruses, highlighting a wide range of pathological and virological diagnostic techniques. This review also focuses on the new oncological scenario ahead, once strategies against carcinogenic infectious agents are found to be effective.

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“…As propriedades biológicas desses 2 tipos são também distintas, o EBV-1 é mais potente do que o EBV-2 na transformação e imortalização de linfócitos B infectados in vitro, mais ambos os tipos de EBV podem atuar como patógenos humanos 3,10 . Muitos estudos têm demonstrado que a expressão de genes virais latentes, especialmente os genes EBNAs e LMP-1 (proteína de membrana latente-1), tem sido intimamente associado com infecção latente que se correlaciona com a imortalização e carcinogênese 11 .…”

Section: Epstein-barr Vírusunclassified

“…O DNA do EBV tem sido isolado com frequência em células do carcinoma de nasofaringe, e está consistentemente associado ao seu desenvolvimento, sendo considerado como um dos seus fatores de risco 17 . Devido ao aumento na detecção de EBV em muitos cânceres, inúmeras pesquisas moleculares sobre o câncer oral, que usam principalmente PCR e métodos de hibridização in situ para detecção do DNA viral e transcrições de RNA, têm sido realizadas em todo o mundo 11 . Até hoje foram usadas várias técnicas em diferentes tipos de fontes de materiais são realizados para detectar o EBV em neoplasias, obtendo diferentes porcentagens de detecção, como demonstrado no quadro na página seguinte.…”

Section: Epstein-barr Vírusunclassified

O Papel do Epstein Barr Vírus na Carcinogênese Oral

Ferreira¹,

Demathé²,

Bernabé³

et al. 2012

Odonto

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RESUMOIntrodução: o carcinoma espinocelular (CEC) é o câncer de cabeça e pescoço de maior ocorrência, representando cerda de 90% de todos esses tumores. O CEC apresenta diversos fatores de risco, como fumo, álcool, e alguns vírus de potencial oncogênico, entre eles o Epstein Barr vírus (EBV) que é um membro da família Herpesviridae e apresenta um tropismo por linfócitos B e também por células epiteliais. Objetivo: realizar um levantamento na literatura da presença do EBV em carcinomas orais. Conclusão: o EBV está intimamente relacionado com carcinoma de nasofaringe, um CEC de alta ocorrência no sudeste asiático, no entanto o seu papel nos demais CEC orais ainda não foi comprovado. Palavras-chave:Infecções por Vírus Epstein-Barr. Neoplasias Bucais. Carcinoma de Células Escamosas. Carcinoma. ABSTRACTIntroduction: the squamous cell carcinoma (SCC) is the head and neck cancer of higher occurrence, representing about 90% of all these tumors. The SCC has several risk factors as smoking, alcohol and some oncogenic viruses, including the Epstein Barr virus (EBV). The EBV is a member of Herpesviridae family and has tropism for B lymphocytes and also for epithelial cells. Aim: the aim of this study was accomplish a review of the literature about the presence of the EBV in oral carcinomas. Conclusion: EBV is closely related to nasopharyngeal carcinoma, a SCC of high incidence in Southeast Asia, however its role in others oral SCC has not been proved.

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Detection of EBV Infection and Gene Expression in Oral Cancer from Patients in Taiwan by Microarray Analysis

Cited by 35 publications

References 56 publications

Oral cancer aetiopathogenesis; past, present and future aspects

Oral cancer aetiopathogenesis; past, present and future aspects

Cancers related to viral agents that have a direct role in carcinogenesis: pathological and diagnostic techniques

O Papel do Epstein Barr Vírus na Carcinogênese Oral

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