Detection of extensively drug resistant pulmonary tuberculosis

Hafez, Sameh; El-Hefnawy, Azza Mahmoud; Hatata, Eman; Ganady, A.A. El; Ibrahiem, M.I.

doi:10.1016/j.ejcdt.2013.07.012

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…The studies were published between 2001 and 2018 and covered different geographical regions: 13 studies were in Asia (three in China, three in Taiwan, two in Georgia, one in Bangladesh, one in Indonesia, one in Iran, one in Thailand, and one in South Korea), three studies were in Europe (one in Spain, one in Portugal, and one in Turkey), eight studies were in the Americas (four in Mexico, two in the USA, and two in Peru), and one study was in Africa (Egypt). From the total studies included in the analysis, nine were case-control [ 18 – 21 , 23 , 25 , 32 , 52 , 54 ], eight were cohort [ 14 , 30 , 31 , 33 – 35 , 53 ], and eight were cross-sectional [ 28 , 48 – 51 ] by study design. No adjustment for confounding was done in 12 of the included studies, while the remaining studies adjusted for at least one confounding factor.…”

Section: Resultsmentioning

confidence: 99%

Association between diabetes mellitus and multi-drug-resistant tuberculosis: evidence from a systematic review and meta-analysis

et al. 2018

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BackgroundDiabetes mellitus (DM) poses a significant risk for the development of active tuberculosis (TB) and complicates its treatment. However, there is inconclusive evidence on whether the TB-DM co-morbidity is associated with a higher risk of developing multi-drug-resistant tuberculosis (MDR-TB). The aim of this meta-analysis was to summarize available evidence on the association of DM and MDR-TB and to estimate a pooled effect measure.MethodsPubMed, Excerpta Medica Database (EMBASE), Web of Science, World Health Organization (WHO), and Global Health Library database were searched for all studies published in English until July 2018 and that reported the association of DM and MDR-TB among TB patients. To assess study quality, we used the Newcastle-Ottawa Scale for cohort and case-control studies and the Agency for Healthcare Research and Quality tool for cross-sectional studies. We checked the between-study heterogeneity using the Cochrane Q chi-squared statistic and I2 and examined a potential publication bias by visual inspection of the funnel plot and Egger’s regression test statistic. The random-effect model was fitted to estimate the summary effects, odds ratios (ORs), and 95% confidence interval (CIs) across studies.ResultsThis meta-analysis of 24 observational studies from 15 different countries revealed that DM has a significant association with MDR-TB (OR = 1.97, 95% CI = 1.58–2.45, I2 = 38.2%, P value for heterogeneity = 0.031). The significant positive association remained irrespective of country income level, type of DM, how TB or DM was diagnosed, and design of primary studies. A stronger association was noted in a pooled estimate of studies which adjusted for at least one confounding factor, OR = 2.43, 95% CI 1.90 to 3.12. There was no significant publication bias detected.ConclusionsThe results suggest that DM can significantly increase the odds of developing MDR-TB. Consequently, a more robust TB treatment and follow-up might be necessary for patients with DM. Efforts to control DM can have a substantial beneficial effect on TB outcomes, particularly in the case of MDR-TB.Systematic review registrationPROSPERO CRD42016045692.Electronic supplementary materialThe online version of this article (10.1186/s13643-018-0828-0) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Association between diabetes mellitus and multi-drug-resistant tuberculosis: evidence from a systematic review and meta-analysis

et al. 2018

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“…This result indicated that MDR-TB sufferers in this study mostly belong to the mild group, which is in contrast with some studies. A study by Hafez et al found that the percentage of patients with MDR-and extensively drug-resistant tuberculosis (XDR-TB) categorized as moderate and severe via observing lesion levels on X-ray chest was 44% and 56%, respectively (Hafez et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Severity of Tb Classified by Modified Bandim Tb Scoring Associates With the Specific Sequence of Esxa Genes in MDR-Tb Patients

Dewi

Mertaniasih

Soedarsono

2020

AJID

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Background: The severity of pulmonary TB and detection of multidrug-resistant (MDR-TB) TB strains as potential causative agents could be crucial for the determination of treatment success. This study aimed to analyze the association between the specific sequences of the full esxA gene from MDR-TB sputum isolates and the severity class of MDR-TB patients. Material and Methods: A total of 98 sputum samples that were suspected to be MDR-TB were collected from Dr. Soetomo, Surabaya, Indonesia, from September to December 2016. A total of 24 isolates from the 98 patients were confirmed to have positive MDR-TB based on the GeneXpert test. MDR-TB isolates were tested using PCR targeting 580 bp encompassing the full esxA gene, and the resulting amplicon was sequenced. The severity class of the pulmonary TB patients was assessed using modified Bandim TB scoring. Results: The patient severity classification resulted in a moderate and severe degree of TB in 38% and a mild degree of TB in 63% of patients. Visualization of the PCR results showed that all MDR-TB samples were positive for the 580 bp band, and the sequence results showed 100% homology with that of the virulent wild-type M. tuberculosis H37Rv (NC_000962.3). Conclusions: In the current study, an association between the characteristics of the full esxA gene and the severity class of MDR-TB patients is yet to be found. However, the homologous sequence of all samples, associated with various degrees of disease severity, possess 100% identity with that of wild-type M. tuberculosis H37Rv.

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“…Research on the incidence of fatigue was found among many previous studies, (83%). 7 No studies on the predictors of fatigue among patients with pulmonary tuberculosis were found domestically or internationally. However, studies were found to have been conducted among patients with infections and other chronic illnesses.…”

Section: Introductionmentioning

confidence: 99%

Factors Predicting Fatigue in Pulmonary Tuberculosis Patients Receiving Anti-Tuberculosis Drugs

et al. 2021

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Objective: To explore the predictive factors on fatigue among pulmonary tuberculosis patients receiving anti-tuberculosis drugs.Methods: This study is a predictive correlational research designed. The sample was comprised of 125 patients at the out-patient department, a tertiary hospital in Bangkok setting. The data were collected between January to February 2020. The questionnaires included mini-cognitive assessment instrument (Mini-Cog); the demographic characteristics questionnaire; Piper fatigue scale-12 (PFS-12); Nutrition alert form (NAF); the Pittsburgh sleep quality index (PSQI); and the Center for epidemiologic studies depression scale (CES-D). All data were analyzed by using descriptive statistics and multiple regression analysis.Results: The sample had a mean age of 58.45 years (SD = 15.374) of which 60.8% were males. Overall, the mean score of fatigue was a moderate level (Mean = 4.90, SD = 2.455). From the multiple regression analysis, age, nutritional status, sleep quality, and depression could explain the variances on fatigue in the sample group as 52.5% (R2 = .525, F = 33.119, p < .001). Nutritional status, sleep quality, and depression are the variables found to be capable in predicting fatigue of pulmonary tuberculosis patients with statistical significance (β = .316, p < .001, β = .226, p < .05 and β = .340, p < .001). Conclusion: Nutritional status, sleep quality, and depression could affect fatigue. Healthcare teams should assess patients to prevent and manage the aforementioned symptoms to reduce suffering from fatigue and a better quality of life.

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Detection of extensively drug resistant pulmonary tuberculosis

Cited by 7 publications

References 14 publications

Association between diabetes mellitus and multi-drug-resistant tuberculosis: evidence from a systematic review and meta-analysis

Association between diabetes mellitus and multi-drug-resistant tuberculosis: evidence from a systematic review and meta-analysis

Severity of Tb Classified by Modified Bandim Tb Scoring Associates With the Specific Sequence of Esxa Genes in MDR-Tb Patients

Factors Predicting Fatigue in Pulmonary Tuberculosis Patients Receiving Anti-Tuberculosis Drugs

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