Detection of fascin and CCR‐7 positive mature dendritic cells in oral lichen planus

Abstract

Our results indicate that DC change from immature to mature in the epithelium and are then drawn out to the submucosa. We demonstrate that mature DC localized in the submucosa, it consequently migrates into lymph vessels. This maturation process of DC is an important immunopathological feature of OLP.

Distinct interferon‐gamma and interleukin‐9 expression in cutaneous and oral lichen planus

“…Light microscopy studies showed a dense lichenoid infiltration of predominantly lymphoid cells, vacuolar degeneration of the basal layer, and apoptotic epithelial cells. In addition to T cells, we detected NK cells, B cells, mast cells, and dendritic cells among inflammatory cells, thus confirming previous reports of a mixed cellular infiltrate . However, T‐cell subsets differed since in OLP the predominant cells were CD8+, whereas in CLP, they were CD4+.…”

“…In addition to T cells, we detected NK cells, B cells, mast cells, and dendritic cells among inflammatory cells, thus confirming previous reports of a mixed cellular infiltrate. [20][21][22][23][24][25] However, T-cell subsets differed since in OLP the predominant cells were CD8+, whereas in CLP, they were CD4+. A predominance of CD8+ among infiltrating cells co-localizing with degenerating apoptotic keratinocytes in OLP has been reported by others.…”

The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus

“…Although there have been many previous reports investigating the role of COX‐2 and PGE2 in the pathogenesis of OLP, to our knowledge this is the first study to investigate the COX‐2 and PGE2 in cutaneous LP.…”

“…Increased expression of COX‐2 is part of the inflammatory process, and COX‐2 has both promoting and inhibitory effects on this process . Increased levels of COX‐2 have been reported in a variety of cancers, and also in autoimmune diseases and oral lichen planus (OLP) lesions …”

“…4,5 Increased levels of COX-2 have been reported in a variety of cancers, 6 and also in autoimmune diseases 7,8 and oral lichen planus (OLP) lesions. [9][10][11][12] This study was performed to declare whether COX-2 and its product prostaglandin E2 (PGE2) have a role in the pathogenesis of cutaneous LP.…”