Detection of free radical formation in various tissues after acute carbon tetrachloride administration in gerbil

Ahmad, Feroz; Cowan, D. L.; Sun, Albert Y.

doi:10.1016/0024-3205(87)90673-4

Cited by 68 publications

(43 citation statements)

References 16 publications

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“…CCl 4 is a well known hepatocarcinogenic agent in laboratory animals 16 . Exposure to CCl 4 has been reported to induce free radical generation in tissues such as liver, heart, lung, testis, brain and blood 17 . The first metabolite of CCl 4 ; trichloromethyl free radical, is believed to initiate the biochemical processes leading to oxidative stress, which is the direct cause of many pathological conditions such as diabetes mellitus, cancer, hypertension, kidney damage, liver damage and death [17][18][19] .…”

Section: Resultsmentioning

confidence: 99%

“…Exposure to CCl 4 has been reported to induce free radical generation in tissues such as liver, heart, lung, testis, brain and blood 17 . The first metabolite of CCl 4 ; trichloromethyl free radical, is believed to initiate the biochemical processes leading to oxidative stress, which is the direct cause of many pathological conditions such as diabetes mellitus, cancer, hypertension, kidney damage, liver damage and death [17][18][19] . Liver damage caused by acute exposure to CCl 4 shows clinical symptoms such as jaundice, swollen and tender liver and elevated levels of liver enzymes in the blood 20,21 .…”

Section: Resultsmentioning

confidence: 99%

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Effect of ethanol extract of <i>Pyrenacantha staudtii</i> leaves on carbontetrachloride induced hepatotoxicity in rats

Anosike¹,

Ugwu²,

Nwakanma³

2010

Biokemistri

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The effect of ethanol extract of Pyrenacantha staudtii leaves on carbontetrachloride (CCl 4 ) induced hepatotoxicity in rats was studied. Sixteen male wistar rats of 100-170g body weight divided into four groups of four rats each, designated -group I, II, III and IV were used. Groups II, III and IV were injected intraperitoneally with 5ml/kg body weight of CCl 4 ; control was injected with 5ml/kg body weight corn oil. After 48hrs, groups III and IV were administered with 750mg/kg and 1500mg/kg body weight of the extract respectively and the rats sacrificed after 5 days. Phytochemical analysis of the extract revealed the presence of alkaloids, glycosides, saponnins, carbohydrates, tannins, flavonoids and resin. Result from the study showed that both concentrations of the extract (750mg/kg and 1500mg/kg body weight) significantly reduced (P < 0.05) CCl 4 induced elevations in the liver enzymes-alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) in a dose dependent manner. CCl 4 induced increases in total and conjugated bilirubin were also significantly lowered by the extract. These results show that the extract of Pyrenacantha staudtii leaves has protective effect against CCl 4 induced liver toxicity and damage.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effect of ethanol extract of <i>Pyrenacantha staudtii</i> leaves on carbontetrachloride induced hepatotoxicity in rats

Anosike¹,

Ugwu²,

Nwakanma³

2010

Biokemistri

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“…Increased ROS generation and lipid peroxidation have been suggested to be responsible for the toxic actions of a wide range of compounds, including solvents such as carbon tetrachloride [26]. While free radical reactions may be associated with many toxic processes, there is little data concerning the reactive oxygen-generating potential of aromatic solvents.…”

Section: Discussionmentioning

confidence: 99%

Effects of toluene and its metabolites on cerebral reactive oxygen species generation

Mattia

LeBel

Bondy

1991

Biochemical Pharmacology

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Abstract-The effects of toluene on lipid peroxidation and rates of reactive oxygen species (ROS) formation have been studied in isolated systems and in vivo. The induction of reactive oxygen species was assayed using the probe 2' ,7'-dichlorofluorescin diacetate (DCFH-DA). Toluene exposure (1 g/kg, 1 hr, i.p.) did not stimulate cortical lipid peroxidation as evaluated by measurement of conjugated dienes. Exposure to toluene, however, both in vivo and in vitro, caused a significant elevation of ROS formation within cortical crude synaptosomal fractions (P2) and microsomal fractions (P3). The ROSinducing properties of toluene were blocked in vivo in the presence of a mixed-function oxidase inhibitor, metyrapone. This suggested that a metabolite of toluene may catalyze reactive oxygen formation. Both benzyl alcohol and benzoic acid, in vitro, were found to have free radical quenching properties, while benzaldehyde exhibited significant induction of ROS generation. It appears that benzaldehyde is the metabolite responsible for the effect of toluene in accelerating reactive oxygen production within the nervous system. Benzaldehyde may also contribute to the overall neurotoxicity of toluene.

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“…Additionally, CCl 4 causes free toxic radical generation in kidneys [5,6]. Various studies demonstrate that some antioxidants protect the liver and kidney from the oxidative damage induced by CCl 4 [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

et al. 2010

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Detection of free radical formation in various tissues after acute carbon tetrachloride administration in gerbil

Cited by 68 publications

References 16 publications

Effect of ethanol extract of <i>Pyrenacantha staudtii</i> leaves on carbontetrachloride induced hepatotoxicity in rats

Effect of ethanol extract of <i>Pyrenacantha staudtii</i> leaves on carbontetrachloride induced hepatotoxicity in rats

Effects of toluene and its metabolites on cerebral reactive oxygen species generation

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

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