Detection of Hepatic Metastases from Colorectal Cancer: Prospective Evaluation of Gray Scale US Versus SonoVue® Low Mechanical Index Real Time-Enhanced US as Compared with Multidetector-CT or Gd-BOPTA-MRI

Cantisani, Vito; Ricci, Paolo; Ertürk, Şükrü Mehmet; Pagliara, E.; Drudi, F. M.; Calliada, Fabrizio; Mortelé, Koenraad J.; D’Ambrosio, U.; Marigliano, Chiara; Catalano, Carlo; Marin, Daniele; Seri, M. Di; Longo, Federico; Passariello, R.

doi:10.1055/s-0028-1109751

Cited by 59 publications

(56 citation statements)

References 15 publications

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“…The unsuccessful directional identification of the flow makes the origin of the endoleak more difficult to detect [14,23]. The emergent role of CEUS and its growing indications compared to CT are also shown by several studies in different fields [24][25][26][27], which prove its applications in the body, for liver, kidney, testis, lymph nodes, thyroid, prostate and small bowel. CEUS with low-mechanical index technique, evaluated in some studies for the EVAR follow-up [8,9,28,29], used second-generation ultrasound contrast agents (e.g., SonoVue Ò ) which employ gas microbubbles of sulfur hexafluoride encapsulated by phospholipid shells.…”

Section: Discussionmentioning

confidence: 99%

What is the role of contrast-enhanced ultrasound in the evaluation of the endoleak of aortic endoprostheses? A comparison between CEUS and CT on a widespread scale

David

Cantisani

Grazhdani³

et al. 2016

J Ultrasound

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Objective To evaluate the accuracy of contrast-enhanced ultrasound (CEUS) in comparison to CT angiography (CTA) to identify and classify endoleaks following abdominal aortic aneurism repair with endoprosthesis. Materials and methods A retrospective analysis of 181 patients treated with EVAR, from September 2009 to September 2014, was performed. Patients were evaluated with CEUS, CTA and angiography in the cases requiring treatment. Sac diameter, sac integrity, identification and classification of endoleaks were taken into consideration. Sensitivity, specificity, accuracy and negative predictive values were considered for each modality of endoleak identification. Results Forty-two endoleaks (23.2%; type II: 39 cases, type III: 3 cases) were documented. Sensitivity and specificity of CEUS and CT were, respectively, 97.6 and 90.5, 100 and 100%. In two cases, CEUS was able to better classify endoleaks compared to CT. Conclusions CEUS accuracy to identify endoleaks following EVAR is similar to CT. CEUS should be considered as an effective modality for the long-term surveillance of EVAR because of its capability to correctly classify endoleaks with no ionizing radiation exposure.Keywords Contrast-enhanced ultrasound Á CT Á Endoleak Riassunto Obiettivi dello studio Valutare l'accuratezza dell'ecocontrastografia (CEUS), confrontandola con angiografia con tomografia computerizzata (CT) per l'identificazione degli endoleak dopo trattamento di aneurisma dell'aorta addominale con endoprotesi. Materiali Da Settembre 2008 a Dicembre 2014, 181 pazienti consecutivi trattati con EVAR sono stati valutati con CEUS, CTA, ed anche con angiografia nei casi da ritrattare. Sono stati valutati: diametro della sacca, valutazione dell'integrita della sacca, identificazione e classificazione degli endoleaks. Sensibilità, specificità, accuratezza e valore predittivo negativo sono stati valutati per ogni modalita nell'identificazione degli endoleak. Risultati Quarantadue endoleak (23.2%; tipo II: 39 casi, tipo III: 3 casi) sono stati documentati. La Sensibilita della CEUS e della TC e stata rispettivamente del 97.6, 90.5%, mentre la specificita per entrambe e stata del 100%. In due casi la CEUS e stata in grado di classificare meglio gli endoleak rispetto alla CT. La sacca aneurismatica presentava alla CEUS e CDUS un diametro massimo compreso tra 39-82 mm, mentre alla TC tra 38 e 78 mm, senza significativa differenza tra le due metodiche. Conclusioni L'accuratezza della CEUS nell'identificazione degli endoleak e nella misurazione della sacca dopo EVAR, e simile alla TC con maggiore sensibilita ma analoga specificita. La CEUS e da considerarsi una modalita efficace per la sorveglianza a lungo termine degli EVAR in quanto capace di classificare correttamente gli endoleak senza esposizione a radiazioni ionizzanti.Parolechiave Contrast-enhanced ultrasound Á CT Á Endoleak

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Section: Discussionmentioning

confidence: 99%

What is the role of contrast-enhanced ultrasound in the evaluation of the endoleak of aortic endoprostheses? A comparison between CEUS and CT on a widespread scale

David

Cantisani

Grazhdani³

et al. 2016

J Ultrasound

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“…Reported MRI sensitivity rates for liver metastases assessment is better than that reported for CT examination (70-98% for MRI [36,38,39] vs. 68-85% for CT [33][34][35]). MRI proved better diagnostic benefit for FLLs <20 mm than MDCT in one study [31].…”

Section: Role Of Mri In Flls Assessmentmentioning

confidence: 45%

“…MRI reaches significantly superior diagnostic efficacy (p < 0.05) as compared to MDCT, both for unenhanced and enhanced examination techniques, with sensitivity, specificity, and accuracy of 86.8%, 94.4%, and 90.4%, respectively for FLLs detection and characterization [31,36]. The American College of Radiology (ACR) Appropriateness Criteria ® consider MRI "the best test for characterizing liver lesions" [37].…”

Section: Role Of Mri In Flls Assessmentmentioning

confidence: 99%

Focal masses in a non-cirrhotic liver: The additional benefit of CEUS over baseline imaging

Chiorean

Cantisani

Jenssen

et al. 2015

European Journal of Radiology

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“…Even hypovascular liver metastases can demonstrate a peripheral hypervascular halo during the arterial phase. The marked washout in the late phase, which lasts up to 4-5 min, aids detection of even very small metastases (less than 5 mm in size) with accuracy at least comparable to CECT and CEMRI [2,[13][14][15]. The enhancement pattern of liver metastases with CEUS is especially helpful because the echogenicity of metastases on conventional grey-scale US may be similar to that of the background liver, making detection without contrast material difficult.…”

Section: Pretreatment Evaluationmentioning

confidence: 99%

Contrast enhanced ultrasound in the evaluation and percutaneous treatment of hepatic and renal tumors

Meloni

Smolock

Cantisani

et al. 2015

European Journal of Radiology

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Detection of Hepatic Metastases from Colorectal Cancer: Prospective Evaluation of Gray Scale US Versus SonoVue® Low Mechanical Index Real Time-Enhanced US as Compared with Multidetector-CT or Gd-BOPTA-MRI

Cited by 59 publications

References 15 publications

What is the role of contrast-enhanced ultrasound in the evaluation of the endoleak of aortic endoprostheses? A comparison between CEUS and CT on a widespread scale

What is the role of contrast-enhanced ultrasound in the evaluation of the endoleak of aortic endoprostheses? A comparison between CEUS and CT on a widespread scale

Focal masses in a non-cirrhotic liver: The additional benefit of CEUS over baseline imaging

Contrast enhanced ultrasound in the evaluation and percutaneous treatment of hepatic and renal tumors

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