Detection of herpes simplex virus in oral tongue squamous cell carcinoma

Koivikko, Tiina; Rodrigues, Priscila Campioni; Vehviläinen, Mari; Hyvönen, P. M.; Sundquist, Elias; Arffman, Riikka K; Al‐Samadi, Ahmed; Välimaa, Hanna; Salo, Tuula; Risteli, Maija

doi:10.3389/fphar.2023.1182152

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…There have been contradictory results discussed in the literature on the involvement of HSV-1 in oral carcinogenesis, that might be important in here presented study on OPMDs [ 47 ]. Latest research however presented that cell survival or invasion was not affected at low doses of HSV-1, when oral tongue squamous cell carcinoma was followed-up [ 47 ]. Further research should be performed in order to establish its role in the OPMDs to provide if similar pattern might be observed.…”

Section: Discussionmentioning

confidence: 85%

HPV related p16INK4A and HSV in benign and potentially malignant oral mucosa pathologies

Duś-Ilnicka,

Hałoń,

Perra

et al. 2024

BMC Oral Health

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Background The association of Human Papilloma Virus (HPV) and Human Syncytial Virus (HSV) infection with inflammatory and potentially malignant disorders of the oral cavity (OPMD) is unknown. The aim of this cross-sectional study was to stablish the expression of the p16INK4A and HSV proteins, to test potential correlation between those parameters in biopsies from clinically diagnosed oral lesions. Methods Immunochemical analysis of 211 formalin-fixed, paraffin-embedded (FFPE) blocks from 211 individuals was provided. The clinical diagnosis included in the research were Oral lichen planus (N = 30), Oral Leukoplakia (N = 13) Mucocele (N = 25), Erosion/ulceration/ inflammation of mucosa (N = 8), Overgrowth of mucosa (N = 135). Results Two hundred eleven analyzed FFPE samples resulted with the median age of 58.5 years (the average age 54.0 years and SD ± 17 years). The female/male ratio was 2.3 (69.7% vs 30.3% respectively). All the samples positive for HSV also expressed p16INK4A (p = 0.000), that’s showed various levels of association with the diverse clinical diagnosis reaching the higher level in OM 49.1% (29 positive samples) and OLP 30.5% (18). p16INK4A was associated with OLP at 30.5% (18), and fibroma 30.5%. HSV expression was mostly present in fibroma at 47.6% (10 positive samples). Conclusion HSV and p16INK4A positivity in relation to diagnosis of the biopsies showed statistically most often p16INK4A in OLP and fibroma. The results of co-expression of p16INK4A and HSV in mucocele and fibroma in oral mucosa suggest a cooperation between the molecular alterations induced by these two viruses. Squamous papilloma samples positive for p16INK4A were also positive for HSV, suggesting that the putative pro-oncogenic action of HSV could be an early event.

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Section: Discussionmentioning

confidence: 85%

HPV related p16INK4A and HSV in benign and potentially malignant oral mucosa pathologies

Duś-Ilnicka,

Hałoń,

Perra

et al. 2024

BMC Oral Health

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“…Further research is needed to explore the mechanisms underlying these correlations and their implications for oral health management and disease prevention strategies. Previous studies have linked oral tongue squamous cell carcinoma (OTSCC) to HSV-1, which may interfere with the cell cycle, activate cell proliferation pathways, and inhibit immune responses, potentially contributing to OC [ 58 ]. Furthermore, HSV-1 infection may increase OC risk through interaction with other carcinogenic factors.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of microbial composition and functional characteristics in dental plaque and saliva of oral cancer patients

Zhang,

Zhao,

Umar

et al. 2024

BMC Oral Health

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Background The oral cavity is home to various ecological niches, each with its own unique microbial composition. Understanding the microbial communities and gene composition in different ecological niches within the oral cavity of oral cancer (OC) patients is crucial for determining how these microbial populations contribute to disease progression. Methods In this study, saliva and dental plaque samples were collected from patients with OC. Metagenomic sequencing was employed to analyze the microbial community classification and functional composition of the different sample groups. Results The results of the study revealed significant differences in both the function and classification of microbial communities between saliva and dental plaque samples. The diversity of microbial species in saliva was found to be higher compared to that in plaque samples. Notably, Actinobacteria were enriched in the dental plaque of OC patients. Furthermore, the study identified several inter-group differential marker species, including Prevotella intermedia, Haemophilus parahaemolyticus, Actinomyces radius, Corynebacterium matruchitii, and Veillonella atypica. Additionally, 1,353 differential genes were annotated into 23 functional pathways. Interestingly, a significant correlation was observed between differentially labeled species and Herpes simplex virus 1 (HSV-1) infection, which may be related to the occurrence and development of cancer. Conclusions Significant differences in the microbial and genetic composition of saliva and dental plaque samples were observed in OC patients. Furthermore, pathogenic bacteria associated with oral diseases were predominantly enriched in saliva. The identification of inter-group differential biomarkers and pathways provide insights into the relationship between oral microbiota and the occurrence and development of OC.

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The emerging role of oral microbiota in oral cancer initiation, progression and stemness

Saikia,

Pathak,

Mitra

et al. 2023

Front. Immunol.

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Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head and Neck cancer. OSCCs are highly inflammatory, immune-suppressive, and aggressive tumors. Recent sequencing based studies demonstrated the involvement of different oral microbiota in oral cavity diseases leading OSCC carcinogenesis, initiation and progression. Researches showed that oral microbiota can activate different inflammatory pathways and cancer stem cells (CSCs) associated stemness pathways for tumor progression. We speculate that CSCs and their niche cells may interact with the microbiotas to promote tumor progression and stemness. Certain oral microbiotas are reported to be involved in dysbiosis, pre-cancerous lesions, and OSCC development. Identification of these specific microbiota including Human papillomavirus (HPV), Porphyromonas gingivalis (PG), and Fusobacterium nucleatum (FN) provides us with a new opportunity to study the bacteria/stem cell, as well as bacteria/OSCC cells interaction that promote OSCC initiation, progression and stemness. Importantly, these evidences enabled us to develop in-vitro and in-vivo models to study microbiota interaction with stem cell niche defense as well as CSC niche defense. Thus in this review, the role of oral microbiota in OSCC has been explored with a special focus on how oral microbiota induces OSCC initiation and stemness by modulating the oral mucosal stem cell and CSC niche defense.

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Detection of herpes simplex virus in oral tongue squamous cell carcinoma

Cited by 5 publications

References 39 publications

HPV related p16INK4A and HSV in benign and potentially malignant oral mucosa pathologies

HPV related p16INK4A and HSV in benign and potentially malignant oral mucosa pathologies

Comparative analysis of microbial composition and functional characteristics in dental plaque and saliva of oral cancer patients

The emerging role of oral microbiota in oral cancer initiation, progression and stemness

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