Detection of herpetic viruses in gingival crevicular fluid of patients suffering from periodontal diseases: prevalence and effect of treatment

Grenier, Geneviève; Gagnon, Guy; Grenier, Daniel

doi:10.1111/j.1399-302x.2009.00542.x

Cited by 67 publications

(73 citation statements)

References 19 publications

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“…[12][13][14] . Infection by HCMV or EBV seems to inhibit the macrophages to respond to bacterial challenge, and thus have pathogenic role in the development of periodontal disease.…”

Section: Human Cytomegalovirus (Hcmv) Epstein-barr Virus (Ebv) and Hmentioning

confidence: 99%

Periodontal disease may associate with breast cancer

Söder

Yakob

Meurman

et al. 2010

Breast Cancer Res Treat

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“…[12][13][14] . Infection by HCMV or EBV seems to inhibit the macrophages to respond to bacterial challenge, and thus have pathogenic role in the development of periodontal disease.…”

Section: Human Cytomegalovirus (Hcmv) Epstein-barr Virus (Ebv) and Hmentioning

confidence: 99%

Periodontal disease may associate with breast cancer

Söder

Yakob

Meurman

et al. 2010

Breast Cancer Res Treat

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“…5 There has been conflicting evidence found in a few studies from around the globe which suggest that the EBV and the HCMV are present at fewer periodontal sites than considered otherwise. [6][7][8][9][10][11][12] Because of the paucity of data and studies with larger sample size in Indian subjects, the exact picture of the presence of the herpesvirus in this population is still unclear. This study was undertaken to determine…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Joshi¹,

Bhat²,

Katti³

et al. 2015

The Journal of Contemporary Dental Practice

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Objective: The identification of new uncultured species and viruses supports the possibility of combination of the herpesvirus-bacterial periodontal infection for periodontitis. The paucity of data and studies with larger sample size in Indian subjects provides an unclear picture of the presence of the herpesvirus in this population. Materials and methods:This was a cross-sectional study consisting of 100 each in the healthy group and chronic periodontitis (CP) group. The subgingival plaque was collected and polymerase chain reaction was performed post deoxyribonucleic acid (DNA) extraction by using specific primers for human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV). The data were analyzed using Fisher's exact test, Mann-Whitney U test and Spearman's coefficient correlation.Results: Human cytomegalovirus and EBV viruses were significantly higher in the CP group as compare to the healthy group. A higher percentage of those with CMV positive had EBV also positive (28.3%) compared to only 9.1% of CMV negative being EBV positive in the CP group. When both the healthy and CP group in total was compared, there was a significant correlation with all clinical parameters. Conclusion:Both the viruses dominated in disease as compared to health were similar to the earlier findings. The CP group had higher pocket depth and clinical attachment loss in the virus positive subjects. These findings could suggest that 91-9620127630, e-mail: drvinayakjoshi@gmail.com virus serves as a prelude to the disease and the combination of the two viruses could play a role in the pathogenesis. Prevalence of Herpesvirus and Correlation with Clinical

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“…A larger number of studies have been conducted on patients with periodontitis. Grenier et al 17 evaluated the 28 . In the present study detection frequency for EBV and CMV observed in patients with periodontitis is consistent with previous reports, confirming their presence in patients with periodontal disease and deep periodontal pockets.…”

Section: Discussionmentioning

confidence: 99%

“…However, in the last decade the presence of herpesviruses has been shown, including HSV1 and 2, EBV, and CMV in periodontal pockets of patients with periodontitis [16][17][18][19][20][21][22] .…”

Section: Discussionmentioning

confidence: 99%