Detection of Hpv Genotypes and Their Association With p53 Codon 72 Polymorphism in Prostate Cancer

Babakhani, Farzad; Azad, Talat Mokhtari; Kondori, Nasim; Jalilvand, Somayeh; Mozhgani, Sayed‐Hamidreza; Ghavami, Nastaran; Farzanehpour, Mahdieh; Babaei, Farhad

doi:10.2217/fvl-2017-0001

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…It seems that the TP53 protein with Pro form (p53‐Pro72) is less susceptible to the E6‐mediated degradation in comparison to the Arg (p53‐Arg72) form. This was reported by Babakhani studying TP53 polymorphism with HPV infection in prostate cancer and confirmed by similar results from Ramya, Hou, Storey, and Nagpal …”

Section: Discussionsupporting

confidence: 87%

Mucosal human papillomavirus detection and TP53 immunohistochemical expression in non‐melanoma skin cancer in Tunisian patients

et al. 2019

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Background: Several studies have reported the oncogenic role of human papillomavirus (HPV) in non-melanoma skin cancer (NMSC) carcinogenesis.Considering that HPV could affect tumor protein 53 (TP53) degradation via E6 oncoprotein, we evaluated the expression of TP53 according to HPV infection and E6 expression. Methods: Biopsy specimens from 79 NMSCs (28 squamous cell carcinomas, 21 keratoacanthomas and 30 basal cell carcinomas) were enrolled. Nested PCR was used to detect mucosal HPV (mHPV) DNA. Genotyping was performed by reverse line hybridization. Expression of TP53 and E6 was evaluated by immunohistochemistry. Results: mHPVs were detected in 34.2% (27/79) of NMSC, with 92.6% (25/27) of high-risk HPV (HR-HPV) types. HPV16-E6-positive expression was observed in all HPV16-positive samples. TP53 high expression was found in 51.4% (37/72) of specimens. In this group, 78.4% were HPV-negative (P = 0.014). TP53 expression was negative in 8/10 of HPV E6-positive specimens.Multivariate analysis showed that TP53 was associated with HPV infection independently of histopathologic type (P = 0.005).Conclusion: This study showed a high prevalence of mHPV in NMSC. Active infections assessed by E6 expression are associated with loss of p53 function, highlighting the involvement of mHPV in NMSC carcinogenesis. K E Y W O R D SHPV16-E6s, mucosal human papillomavirus, non-melanoma skin cancer, TP53, Tunisian

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Section: Discussionsupporting

confidence: 87%

Mucosal human papillomavirus detection and TP53 immunohistochemical expression in non‐melanoma skin cancer in Tunisian patients

et al. 2019

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The role of viruses in adenocarcinoma development

Nakhaie

Charostad

Kaydani

et al. 2020

Infection, Genetics and Evolution

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GSTP , GSTT1 , XRCC1 and CASP8 Genetic Variations are Associated with Human Papillomavirus in Women with Cervical Cancer From Zimbabwe

Kuguyo,

Dube Mandishora,

Soko

et al. 2024

Future Virol.

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Aim: Investigate the role of host genetic variations in high-risk human papillomaviruses (HR-HPVs). Methods: This cross-sectional study recruited 238 cervical cancer patients. Variants in transport (ABCC2), xenobiotic metabolism ( GSTP, GSTT1, GSTM1, NQO1), DNA repair ( ERCC1, XRCC1), immune response ( TLR4) and apoptosis ( CASP8, FASL, p53) genes were characterized. Tumor DNA was genotyped for 14 HR-HPVs. Results: GSTP rs1695GG, XRCC1 rs1799782TT and GSTT1 del/del were associated with HPV51 (odds ratio [OR]: 3.9; 95% confidence interval [CI]: 1.3–11.7; p = 0.02) and HPV58 (OR: 2.4; 95% CI: 1.2–5.8; p = 0.048), respectively. CASP8 rs3834129del/del was associated with HPV16/18 (OR: 2.7; 95% CI: 1.2–6.0; p = 0.017) and HPV monoinfections (OR: 2.3; 95% CI: 1.2–4.4; p = 0.008). Conclusion: GSTP, GSTT1, XRCC1 and CASP8 variants were associated with HPV-positivity. With further research, a genetic-based screening tool can be developed, to use with HPV vaccines toward preventing cervical cancer.

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Detection of Hpv Genotypes and Their Association With p53 Codon 72 Polymorphism in Prostate Cancer

Cited by 3 publications

References 33 publications

Mucosal human papillomavirus detection and TP53 immunohistochemical expression in non‐melanoma skin cancer in Tunisian patients

Mucosal human papillomavirus detection and TP53 immunohistochemical expression in non‐melanoma skin cancer in Tunisian patients

The role of viruses in adenocarcinoma development

GSTP , GSTT1 , XRCC1 and CASP8 Genetic Variations are Associated with Human Papillomavirus in Women with Cervical Cancer From Zimbabwe

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