Detection of Human Papillomavirus 60 in Epidermal Cysts of Nonpalmoplantar Location

Abstract

Human papillomavirus (HPV) types 57 and 60 are associated with epidermal cysts of palmoplantar location (PPECs). Recently, there was a report of HPV 60 in a wart located in a nonpalmoplantar area as a possible precursor of a nonpalmoplantar epidermal cyst (NPPEC). There has been no study that has examined the presence and frequency of HPV in ordinary NPPECs. We reviewed 63 cases of epidermal cysts, including 59 NPPECs and 4 PPECs. After routine histopathologic review, polymerase chain reaction (PCR) of extracted DNA, sequencing of PCR products, and, finally, a homology search were undertaken. As a result, 9 of 63 (14.3%) cysts, including 6 of 59 NPPECs (10.2%), showed a positive reaction on PCR. By homology search after PCR, all were demonstrated as HPV 60. For NPPECs, no variables, including some histopathologic features, are significantly related to the presence of HPV 60 in univariate or multivariate analysis (P > 0.05).

MRI Findings of Subcutaneous Epidermal Cysts: Emphasis on the Presence of Rupture

“…Epidermal cysts are probably formed by several mechanismsremnant ectodermal tissues misplaced during embryogenesis [10], occlusion of the pilosebaceous unit, or traumatic or surgical implantation of epithelial elements [9,11]. Human papillomavirus type 57 or 60 infections may be additional factors in the development of palmoplantar epidermoid cysts [12,13].…”

Epidermal inclusion cyst of the maxillofacial region

“…Human papillomavirus type 57 or 60 infections may be additional factors in the development of palmoplantar epidermoid cysts [9][10][11]. Oral and pharyngeal epidermoid cysts of the inclusion cyst variety also occur, but are rare in adults and are frequently so small that they are not biopsied.…”

Intracranial Dysontogenetic Tumors In Children: Topographic-Histologic Correlations, Own Experience And Review Of The Literature

“…Several reports highlight the role of human papillomavirus in the development of DT-related tumors and presence of carcinoembryonal antigen in affected persons [23][24][25][26]. Cancerogenesis may be heralded by rapid enlargement of a hitherto stable lesion and visible contrast enhancement on imaging studies.…”