Detection of Human Papillomavirus DNA in Malignant Lesions from Chinese Women with Carcinomas of the Upper Genital Tract

Ip, Shabalova; Wong, L.C.; Xu, Chunyan; Cheung, Annie N.Y.; Tsang, Paul Wai-Kei; Ngan, Hextan Y.S.

doi:10.1006/gyno.2002.6784

Cited by 36 publications

(51 citation statements)

References 33 publications

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“…Only in four of the 10 studies, HPV infection was found in ovarian cancers (Lai et al, 1992(Lai et al, , 1994Zimna et al, 1997;Ip et al, 2002). It is interesting that in three of the positive reports, specimens of Chinese origin were used (Lai et al, 1992(Lai et al, , 1994Ip et al, 2002). In the present study, a total of 54 ovarian cancers and 30 nontumour ovarian specimens were analysed for the presence of HPV-16.…”

Section: Discussionmentioning

confidence: 74%

“…Therefore, the involvement of HPV infection in epithelial ovarian cancer has been an interesting issue. However, previous studies in different laboratories provided highly controversial results (Kaufman et al, 1987;Leake et al, 1989;Beckmann et al, 1991;Lai et al, 1992Lai et al, , 1994Duggan et al, 1995;Runnebaum et al, 1995;Sworn et al, 1995;Trottier et al, 1995;Anwar et al, 1996;Kedzia et al, 1996;Mai et al, 1996;Zimna et al, 1997;Manolitsas et al, 1998;Anttila et al, 1999;Chen et al, 1999;Ip et al, 2002). We report here that HPV-16 was found in a series of histologically characterised epithelial ovarian carcinomas from Chinese women.…”

mentioning

confidence: 56%

“…To date about 16 additional reports on HPV infection in ovarian tumours were found in the MEDLINE. Among these, 10 analysed more than 10 tumour specimens in each report (Leake et al, 1989;Beckmann et al, 1991;Lai et al, 1992Lai et al, , 1994Runnebaum et al, 1995;Trottier et al, 1995;Zimna et al, 1997;Anttila et al, 1999;Chen et al, 1999;Ip et al, 2002). Only in four of the 10 studies, HPV infection was found in ovarian cancers (Lai et al, 1992(Lai et al, , 1994Zimna et al, 1997;Ip et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

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Detection of human papillomavirus-16 in ovarian malignancy

Guo

et al. 2003

Br J Cancer

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Human papillomavirus is the causal factor for cervical cancer. However, the role of HPV infection in ovarian cancer is unclear. This study aimed to determine the presence of human papillomavirus-16 (HPV-16) in ovarian cancer tissues. Archived human ovarian cancer tissues (N ¼ 54 cases, 50 are epithelial cancer, four are nonepithelial cancer) embedded in paraffin blocks were used. Controls are 30 nonmalignant ovarian tissue blocks. In situ hybridisation (ISH) and immunohistochemistry (IHC) were used to detect the presence of HPV-16 and p53 expression. In all, 52 or 36% of the epithelial ovarian tumours detected by ISH or IHC, respectively, were HPV-16 E6 positive. In contrast, only 6.7% of normal ovarian tissues were HPV-16 positive proved by ISH. Human papillomavirus-16 infection was significantly higher in cancer tissues compared to controls with an odds ratio of 16.7 (95% confidence interval [CI] ¼ 3.2 -71.4, Po0.01). No significant correlation between HPV-16 infection and histological types of cancer was found (P40.05). p53 gene expression was detected in 42% epithelial ovarian cancers. No correlation between p53 expression and HPV-16 infection was found. The results showed the presence of HPV-16 E6 in ovarian carcinoma, suggesting that HPV infection might play a role in ovarian carcinogenesis.

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Section: Discussionmentioning

confidence: 74%

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confidence: 56%

Section: Discussionmentioning

confidence: 99%

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Detection of human papillomavirus-16 in ovarian malignancy

Guo

et al. 2003

Br J Cancer

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“…In addition, they showed that the prevalence of HPV-16 increased during 2000 to 2005 and started to decrease after 2006 in OCa patients (24). The highest prevalence of HPV in OCa patients was 26.9% -35.9%, all of whom were from China (24,29,30). Our results, in comparison with previous studies, showed that the prevalence of HPV-16 in OCa patients has increased in our country; it, of course, could be predicted as the highest prevalence of HPV is in Asia among the continents.…”

Section: Discussionmentioning

confidence: 99%

Detection of Human Papilloma Virus Type 16 in Epithelial Ovarian Tumors Samples

Dadashi

Eslami

Faghihloo

et al. 2016

Arch Clin Infect Dis

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Background: Ovarian carcinoma is the most common malignancy in women and is a cancer with a 15% -50% prevalence in the world. Human papilloma virus (HPV) is considered a factor in cervical and ovarian cancer (OCa) and is related to squamous cell carcinoma in the cervical region. The effect of fixed infection may cause chronic inflammation, in the cancer of ovaries it has received very rare attention, although a background of pelvic inflammatory disease (PID) in a case-control study is associated with a higher risk for ovarian carcinoma. HPV-16 is one type of HPV and the most common and important cause of cervical carcinoma in the developed world. Objectives: The aim of this investigation was to evaluate the incidence of HPV-16 in patients with OCa who referred to Imam Hossein hospital of Shahid Beheshti University of Medical Sciences, Tehran, Iran. Methods: In this case-control study that was conducted since May 2015 to October 2015 in Tehran, 140 samples were studied which were obtained from patients with OCa. After obtaining the samples from OCa tissue by a pathologist, for DNA extraction, samples were transferred to the laboratory of the university. DNA was extracted with Kit (intron biotechnology Co. Korea) according to the manufacturer's instructions. To confirm the presence of HPV-16 in the samples of OCa, specific primers for the L1 gene of HPV were designed and standard PCR method was used for the detection of HPV. PCR product was sequenced to confirm the presence of HPV-16. Results: Out of 140 samples of OCa, 70 (50%) samples were malignant cancer and 70 (50%) were benign cancer as the control group. Out of 70 malignant samples 25 (36.0%) were HPV-16 positive. 2.8% of the tissue samples of the control group were positive for HPV-16. Conclusions: These results show a feasible role of HPV-16 in the carcinogenesis of OCa. According to these results, infection with HPV may play a relative role in the spread of OCa or it could comfort its development.

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“…Some studies have reported that HPV has been isolated from ovarian cancer tissues, although at a lower rate than cervical cancer. 5,6 But in most studies, HPV was not isolated, or isolated only in some cases of ovarian cancer, and the likelihood that HPV plays a role in ovarian carcinogenesis is thought to be low. 4,7,8 This means that identification of HPV DNA in ovarian tumors may provide evidence of a metastatic cancer.…”

Section: Discussionmentioning

confidence: 99%

A case of advanced gynecologic pelvic tumors showing the diagnostic utility of HPV analysis

Lee

et al. 2009

J Gynecol Oncol

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Gynecologic malignancies may have similar histological characteristics. This may lead to difficulties in determining the origin of the cancer and to distinguish a synchronous neoplasm from a metastatic cancer in advanced cases. Recently, we treated a 59-year-old patient with adenocarcinoma of the uterine cervix, endometrium, fallopian tubes, and ovaries. It was difficult to determine whether the cancer was a single origin metastatic cancer or a synchronous neoplasm. The patient was finally diagnosed with metastatic cancer that originated from the uterine cervix by human papillomavirus (HPV) test. Here we report the case and briefly review of the medical literature.

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Detection of Human Papillomavirus DNA in Malignant Lesions from Chinese Women with Carcinomas of the Upper Genital Tract

Cited by 36 publications

References 33 publications

Detection of human papillomavirus-16 in ovarian malignancy

Detection of human papillomavirus-16 in ovarian malignancy

Detection of Human Papilloma Virus Type 16 in Epithelial Ovarian Tumors Samples

A case of advanced gynecologic pelvic tumors showing the diagnostic utility of HPV analysis

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