Detection of human papillomavirus in the oral cavities of persons with <scp>F</scp>anconi anemia

Huang, Claire E.; Cherne, Stephen; Stern, Joshua; Kovacic, Melinda S. Butsch; Mehta, Parinda A.; Sauter, Sharon; Galloway, Denise A.; Katzenellenbogen, Rachel A.

doi:10.1111/odi.12286

Cited by 9 publications

(12 citation statements)

References 28 publications

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“…In this case series study, 28% of the FA patients admitted to an HSCT reference center had HPV detected in the oral mucosa, which is higher than estimates from other studies with FA patients and also higher than estimates from studies with the general population, 7.5% to 11.1% and 6.9%, respectively …”

Section: Discussioncontrasting

confidence: 71%

“…Lowy and Gillison suggested that the period between HPV infection and the development of cancer may be considerably shorter in FA patients, which could explain the occurrence of head and neck SCC (HNSCC) or vulvar cancer in relatively young FA patients. While some studies have failed to detect HPV DNA in HNSCC and anogenital SCC samples from subjects with FA, some epidemiological studies continue to provide evidence of risk …”

Section: Introductionmentioning

confidence: 99%

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High frequency of multiple HPV types detection in Fanconi anemia patients oral swabs

Portugal

Raboni

Nogueira

et al. 2018

Transplant Infectious Dis

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Background Fanconi anemia (FA) is a rare genetic disease usually characterized by bone marrow failure and congenital malformations. The risk of development of malignancies in the oral cavity of FA patients, such as squamous cell carcinoma (SCC), increases significantly after a hematopoietic stem cells transplant (HSCT), and may also be linked with the presence of human papillomavirus (HPV) infections in the oral cavity. We investigated the prevalence and the HPV genotypes in oral mucosa of Brazilian FA patients. Methods and results Oral swabs of 49 FA patients were collected. The median age of patients was 20 years (range 5‐44) and 57% were over 18 years. Oral lesions were present in 20% of all patients, being 90% leukoplakia. HPV DNA was detected in 28% (14/49) of patients, and one of them also reported genital HPV lesions. Sixty‐seven percent of all patients had undergone HSCT, including 12 patients (86%) of those with HPV results. Multiple HPV types were detected in 78% and 71% of HPV samples by Sanger sequencing and reverse hybridization methods, respectively. The most prevalent HPV types detected were 6, 11, 18, and 68. Conclusions HPV prevalence in the oral mucosa of the assessed FA patients was higher than reported in the general population. Additional studies with collection of sequential samples are needed to know the natural history of the presence of multiple HPV types in these individuals and its association with the development of tumors, to evaluate the implementation of preventive measures, such as vaccination, and to guide early treatment.

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Section: Discussioncontrasting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

High frequency of multiple HPV types detection in Fanconi anemia patients oral swabs

Portugal

Raboni

Nogueira

et al. 2018

Transplant Infectious Dis

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“…It is plausible, although speculative, that less common high-risk types, or even low-risk HPV types, might unusually initiate a cancer cascade in those with FA who have both a DNA repair defect and heterogeneous immune deficiency, suggesting a need to evaluate the broad spectrum of HPV types rather than HPV16 and 18 alone in oral rinse and possibly other sample types. Indeed, among 67 throat swabs from individuals with FA collected at the same time as our oral rinse samples in this report, we identified 5 individuals positive for HPV 33, HPV 84, HPV 66, 51, 52, 62 82 and HPV 51; a 60% agreement between sample types (32). …”

Section: Discussionmentioning

confidence: 68%

Oral Human Papillomavirus Is Common in Individuals with Fanconi Anemia

Sauter

Wells

Zhang

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Fanconi Anemia (FA) is a rare genetic disorder resulting in a loss of function of the FA-related DNA repair pathway. Individuals with FA are predisposed to some cancers including oropharyngeal and gynecological cancers with known associations with human papillomavirus (HPV) in the general population. Since individuals with FA respond poorly to chemotherapy and radiation, prevention of cancer is critical. Methods To determine if individuals with FA are particularly susceptible to oral HPV infection, we analyzed survey-based risk factor data and tested DNA isolated from oral rinses from 126 individuals with FA and 162 unaffected first-degree family members for 37 HPV types. Results Fourteen individuals (11.1%) with FA tested positive, significantly more (p=0.003) than family members (2.5%). While HPV prevalence was even higher for sexually active individuals with FA (17.7% vs. 2.4% in family; p=0.003), HPV positivity also tended to be higher in the sexually inactive (8.7% in FA vs. 2.9% in siblings). Indeed, having FA increased HPV positivity 4.9 fold (95%CI: 1.6–15.4) considering age and sexual experience, but did not differ by other potential risk factors. Conclusion Our studies suggest that oral HPV is more common in individuals with FA. It will be essential to continue to explore associations between risk factors and immune dysfunction on HPV incidence and persistence over time. Impact HPV vaccination should be emphasized in those with FA as a first step to prevent oropharyngeal cancers, although additional studies are needed to determine if the level of protection it offers in this population is adequate.

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“…Recently, the prevalence of oral HPV infection in patients with FA (and without OPSCC) was assessed and the results were found to be similar to studies of the general population, with the prevalence of oral HPV being 7.5 % (Winer et al 2015). The prevalence of high-risk HPVinfection was 6 %, but oral HPV16 was not observed.…”

Section: The Prevalence Of Hpv Infectionmentioning

confidence: 83%

Epidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Gollin

2015

Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer

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Detection of human papillomavirus in the oral cavities of persons with Fanconi anemia

Cited by 9 publications

References 28 publications

High frequency of multiple HPV types detection in Fanconi anemia patients oral swabs

High frequency of multiple HPV types detection in Fanconi anemia patients oral swabs

Oral Human Papillomavirus Is Common in Individuals with Fanconi Anemia

Epidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma

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