Epidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Gollin, Susanne M.

doi:10.1007/978-3-319-21100-8_1

Cited by 6 publications

(10 citation statements)

References 79 publications

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“…Oropharyngeal cancers (OPC) are found on the base of the tongue, pharyngeal tonsils, anterior and posterior tonsillar pillars, glossotonsillar sulci, anterior surface of the soft palate and uvula, and lateral and posterior pharyngeal walls . Most HPV‐related OPC form on either the tonsils or the base of the tongue . The prevalence of HPV‐related OPC has been steadily rising.…”

Section: Introductionmentioning

confidence: 99%

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Dental professionals' knowledge, attitudes, and practice behaviors related to human papillomavirus vaccination

Patel

Koskan

Spolarich

et al. 2019

J Public Health Dent

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Objectives In Arizona, human papillomavirus (HPV)‐related cancers are declining, with the exception of oropharyngeal cancer (OPC). HPV‐related OPC is largely caused by persistent infection with oncogenic HPV strains, many of which the 9‐valent HPV vaccine offers protection. Little is known about dental professionals' willingness to promote the HPV vaccine to prevent OPC. The current study assessed Arizona dental professionals' knowledge, attitudes, willingness, and current practice behaviors related to HPV vaccine promotion. Responses between dentists and hygienists were also compared. Methods A convenience sample of 711 dentists and hygienists attending a regional conference were recruited and asked to complete a 34‐item survey assessing knowledge and attitudes about HPV, the HPV vaccine, HPV‐related OPC, and their willingness to promote and administer the HPV vaccine. Fisher's exact tests and Mann–Whitney U tests were used for data analysis. Results Most respondents answered HPV knowledge questions correctly but did not know HPV‐related OPC has a more favorable prognosis than other head and neck cancers. Dentists were more confident discussing and recommending the HPV vaccine. Both dentists and hygienists were willing to refer patients to their non‐dental primary care providers for vaccination; however, they were less confident in administering the vaccine if it fell within their scope of practice. They reported willingness to receive training to recommend the vaccine. Conclusions Given the willingness of respondents to receive training related to HPV vaccine communication, future research should develop and test talking points and communication training to aid dentists and hygienists in their promotion of the HPV vaccine.

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Section: Introductionmentioning

confidence: 99%

“…2 Most HPV-related OPC form on either the tonsils or the base of the tongue. 3 The prevalence of HPV-related OPC has been steadily rising. For example, from 1988 to 2004, there was a 225 percent increase in HPV-related OPC.…”

Section: Introductionmentioning

confidence: 99%

Dental professionals' knowledge, attitudes, and practice behaviors related to human papillomavirus vaccination

Patel

Koskan

Spolarich

et al. 2019

J Public Health Dent

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“…It is believed that the circular genome is linearized and integrated as a late event in the infection process, destroying the region of the E1/E2 gene, destroying the E2 gene, releasing the suppression of the viral genome, leading to the overexpression of E6 viruses and E7 genes to maintain the malignant phenotype [38]. E5, E6 and E7 proteins are the most important for oncogenic transformation [39]. In the early stages of carcinogenesis the E5 protein plays a role and appears to increase cellular EGFR signaling, leading to up-regulation of viral gene expression and cell proliferation [37].…”

Section: Hpv and The Potential For Malignancymentioning

confidence: 99%

“…HPV can cause latent infection in basal cells after mucosal epithelial surface erosion by low HPV DNA copy; transmission of infection can occur only when the number of the viruses is sufficient [63]. HPV can also cause subclinical infection that is active but asymptomatic; or clinical infection leading to benign, potentially malignant or malignant lesions [39,63]. Most HPV infections are cleared by the immune system; the individual is not aware he or she has had the infection and does not develop visible lesions or cancer [64,65].…”

Section: Transmission Of Oral Hpv Infectionmentioning

confidence: 99%

The Presence of HPV in Dental Calculus: It’s Role in Pathogenesis of Oral and Cervical Cancer

Widyaputra¹,

Pranata²,

Setiawan³

et al. 2021

Cervical Cancer - A Global Public Health Treatise

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Human papillomavirus (HPV) infection accounts for approximately 5.2% of the worldwide human cancer burden. Molecular epidemiologic evidence clearly indicates that certain types of HPV are the principal cause of both cervical and oral cancers. Major oncoproteins E6 and E7 can inactivate p53 and pRB proteins because it happened genome instability and dysregulation host cell cycles. This virus is an epithelial tropism, vulnerable area mainly at the basal layer and epithelial stem cell, because it still has a high proliferation capacity, so it can support the replication of the virus. Virions bind initially to the glycosaminoglycan (GAG) chains of heparan sulphate proteoglycan (HSPG). More than 99% cervical cancer arise at the cervical transformation zone. In oral cavity, exposed areas of the basal layer will be very susceptible to HPV infection. The HPV presence in the oral area is considered as one of the etiologics of oral cancer in those who do not have bad habits such as smoking, betel chewing, or poor oral hygiene. Our study successfully identified HPV type 58 in dental calculus. Dental calculus, calcified oral plaque biofilm, has been shown to be an abundant, nearly ubiquitous, and long-term reservoir of the ancient oral microbiome, including bacteria, archaea, eukaryote, and viruses. During biomineral maturation process, several biological contents around the oral region should be trapped, including the exfoliated virus contained cells. Dental calculus is a promising source of HPV and carcinogens molecules in the oral cavity and could be used as a biomarker for early detection.

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“…Data yang digunakan sebanyak 100 barisan DNA yang berbeda yang terdiri dari 25 barisan DNA virus Human Papillomavirus (HPV) [6], 25 barisan DNA virus Ebola [7], 25 barisan DNA virus Marburg [8], dan 25 barisan DNA virus Zika [9]. Pemilihan data virus tersebut didasarkan pada sifat virus yang berbahaya bagi manusia, bahkan ada yang menyebabkan kematian.…”

Section: Pengumpulan Data Barisan Dnaunclassified

Penggunaan N-mers Frequency pada Analisis Barisan DNA

Umam

Sagara

2020

Jambura J. Math

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Salah satu metode untuk menganalisis barisan DNA adalah menggunaan N-mers Frequency. N-mers Frequency termasuk metode data mining pada barisan DNA, dimana barisan DNA yang merupakan data string “ACGT” akan diubah menjadi data numerik. N-mers Frequency pada tulisan ini menggunakan N = 3. Hal ini disebabkan karena pada proses sintesis protein, tRNA akan membawa tiga basa nekleotida (anti kodon) yang akan dipasangkan dengan tiga basa nekleotida (kodon) pada pita mRNA. Dalam hal ini mRNA dibentuk dari duplikasi barisan DNA. Studi ini dilakukan untuk mengetahui akurasi dari penggunaan N-mers Frequency. Untuk menghitung Akurasi penggunaan N-mers Frequency, dilakukan tahapan seperti berikut: (1) pengumpulan data barisan DNA, (2) N-mers Frequency, (3) matriks jarak, (4) pengelompokan menggunakan algoritma K-means++, PAM, AGNES, dan DIANA, (5) menghitung akurasi, dan (6) kesimpulan. Akurasi dari Penggunaan N-mers Frequency pada penelitian ini adalah 100%, dengan menggunakan data 100 barisan DNA yang telah diketahui jenisnya, yaitu: virus HPV, virus Ebola, virus Marburg, dan virus Zika.

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Epidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma

Cited by 6 publications

References 79 publications

Dental professionals' knowledge, attitudes, and practice behaviors related to human papillomavirus vaccination

Dental professionals' knowledge, attitudes, and practice behaviors related to human papillomavirus vaccination

The Presence of HPV in Dental Calculus: It’s Role in Pathogenesis of Oral and Cervical Cancer

Penggunaan N-mers Frequency pada Analisis Barisan DNA

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