Detection of human parechovirus (HPeV)-3 in spinal fluid specimens from pediatric patients in the Chicago area

Walters, B; Peñaranda, Silvia; Nix, W. Allan; Oberste, M. Steven; Todd, Kathleen; Katz, Ben Z.; Zheng, Xiaotian

doi:10.1016/j.jcv.2011.07.008

Cited by 55 publications

(47 citation statements)

References 31 publications

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“…Interestingly, we did not observe any significant differences in EV viral load when comparing children <3 months of age and ≥3 months of age or <1 y.o and ≥1 y.o. HPeV typing shows that HPeV type 3 was detected in all children <1 y.o, as previously observed [2,4,6,14,15].…”

Section: Discussionsupporting

confidence: 85%

Enterovirus and Parechovirus viraemia in young children presenting to the emergency room: Unrecognised and frequent

Cordey

L’Huillier

Turin

et al. 2015

Journal of Clinical Virology

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Section: Discussionsupporting

confidence: 85%

Enterovirus and Parechovirus viraemia in young children presenting to the emergency room: Unrecognised and frequent

Cordey

L’Huillier

Turin

et al. 2015

Journal of Clinical Virology

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“…[1][2][3][4][5][6][7][8] HPeV genotype 3 (HPeV3) is thought to be particularly neurotropic, being frequently identified from the cerebrospinal fluid (CSF) of infants with sepsislike presentations. 2,[8][9][10][11][12][13][14] HPeV3 central nervous system (CNS) infection is associated with young age (<3 months) and absence of CSF pleocytosis. 2,4,6,9,[11][12][13][14][15][16][17][18][19][20] Most reports of HPeV infection of the CNS have been retrospective series identified through sampling of archived laboratory specimens, without application of clinical case definitions for encephalitis.…”

mentioning

confidence: 99%

“…2,[8][9][10][11][12][13][14] HPeV3 central nervous system (CNS) infection is associated with young age (<3 months) and absence of CSF pleocytosis. 2,4,6,9,[11][12][13][14][15][16][17][18][19][20] Most reports of HPeV infection of the CNS have been retrospective series identified through sampling of archived laboratory specimens, without application of clinical case definitions for encephalitis. 2,5,6,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] As a result, the syndrome of CNS infection with HPeV is inadequately characterized.…”

mentioning

confidence: 99%

“…2,5,6,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] As a result, the syndrome of CNS infection with HPeV is inadequately characterized. Further definition of HPeV CNS syndromes are needed because although many infants have benign outcome after CNS infection, 4,8,13,16 there have been isolated reports of adverse neurodevelopmental outcomes with HPeV3 in the context of abnormal neuroimaging. 3,26,27 Encephalitis is the most severe manifestation of HPeV CNS infection and rigorous case definitions for encephalitis have been published in the past 10 years in studies from California, 28 the United Kingdom, 29 and France, 30 as well as consensus definitions from the Brighton Collaboration 31 and the International Encephalitis Consortium.…”

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confidence: 99%

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Parechovirus Encephalitis and Neurodevelopmental Outcomes

et al. 2016

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“…period of time (http://www.picornaviridae.com/parechovirus /parechovirus.htm), but only one of those, HPeV-3, seems to be specifically involved in SLI (3,(7)(8)(9)(10)(11)(12); for a review, see reference 13). Here we describe two unlinked cases of SLI caused by HPeV-3, whose sources in both cases could be traced back to elder siblings with mild gastroenteritis and respiratory illness.…”

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confidence: 99%

Two Cases of Sepsis-Like Illness in Infants Caused by Human Parechovirus Traced Back to Elder Siblings with Mild Gastroenteritis and Respiratory Symptoms

et al. 2013

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c Sepsis and sepsis-like illness in neonates and infants are serious emergencies. Recently, human parechovirus type 3 (HPeV-3) has been identified as a further etiologic agent of these conditions. We report two unlinked cases of infant HPeV-3 sepsis-like illness whose sources could be traced back to elder siblings with mild gastroenteritis and respiratory symptoms. CASE REPORTSP atient 1, a 7-day-old full-term male newborn with a birth weight of 3,750 g was admitted in August 2010 to the intensive care unit of a pediatric tertiary-care center because of his severely reduced general condition and pale skin color. A physical examination revealed tachyarrhythmia, mild hypertonia, a prolonged capillary filling time, a slightly elevated temperature (38°C), and an erythematous macular rash. A chest X-ray, a cranial ultrasound, and an electroencephalogram demonstrated no abnormalities. An abdominal ultrasound examination detected a slight increase of the amount of free fluid and a remarkably echogenic pancreas. Serum analysis showed a slightly raised C-reactive protein (CRP) level (28.3 mg/liter; normal, Յ3 mg/liter) and an elevated interleukin-6 concentration (191 pg/ml; peak, 272 pg/ml on day 2; normal, Յ15 pg/ml), and a moderately reduced platelet count (165 ϫ 10 9 /liter; nadir, 107 ϫ 10 9 /liter on day 6; normal, 230 ϫ 10 9 to 520 ϫ 10 9 /liter) ( Fig. 1). Empirical antibiotic therapy with tobramycin and piperacillin-tazobactam was initiated. Antiviral therapy with acyclovir was initiated in parallel but withdrawn after a negative result of a herpes simplex virus (HSV) PCR assay of cerebrospinal fluid was obtained.Bacterial cultures of blood and swabs from the ear canal, nose, throat, and rectum yielded no pathological findings. PCR or reverse transcription (RT)-PCR assays of cerebrospinal fluid, serum, EDTA blood, nasopharyngeal aspirate, urine, and feces were negative for HSV, cytomegalovirus (CMV), measles virus, and enterovirus. All specimens except urine tested positive for human parechovirus (HPeV) by RT-PCR, as illustrated in the top panel of Fig. 1 (for the method used, see reference 1). Because virus was detected in cerebrospinal fluid, cranial magnetic resonance imaging was done but no structural abnormalities or signs of meningoencephalitis were seen. Exanthema and enanthema disappeared after 4 days. Of note, HPeV viremia remained detectable up to days 6 and 8 of hospitalization. The patient was discharged after 10 days in good clinical condition. The full genome of the virus was sequenced (7,278 nucleotides), indicating the presence of HPeV type 3 (HPeV-3) with a recombination pattern involving nonstructural protein genes typical of HPeV-6 (breakpoint around nucleotide position 5150, according to the position numbering of HPeV-3 reference strain A308/99, GenBank accession no. AB084913; please note that HPeV types are defined upon their structural [capsid] gene portions; sequencing was performed using BigDye Terminator Cycle Sequencing chemistry [Applied Biosystems, Darmstadt, Germany], and the sequence...

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Detection of human parechovirus (HPeV)-3 in spinal fluid specimens from pediatric patients in the Chicago area

Cited by 55 publications

References 31 publications

Enterovirus and Parechovirus viraemia in young children presenting to the emergency room: Unrecognised and frequent

Enterovirus and Parechovirus viraemia in young children presenting to the emergency room: Unrecognised and frequent

Parechovirus Encephalitis and Neurodevelopmental Outcomes

Two Cases of Sepsis-Like Illness in Infants Caused by Human Parechovirus Traced Back to Elder Siblings with Mild Gastroenteritis and Respiratory Symptoms

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