Detection of Human Salivary Gland Virus in the Mouth and Urine of Children1

Rowe, Wallace P.; Hartley, Janet W.; Cramblett, Henry G.; Mastrota, Francis M.

doi:10.1093/oxfordjournals.aje.a119919

Cited by 47 publications

(25 citation statements)

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“…The duration of detectable PCMV excretion by naturally infected pigs was much shorter than that of CMV in infected mice and children; periods of 15-24 months or more have been recorded in the latter (Rowe, Hartley, Cramblett & Mastrota, 1958; Weller & Hanshaw, 1962;Medearis, 1964a) and 6-12 months in the former (Brodsky & Rowe, 1958;Medearis, 1964b). We have found that nasal excretion of PCMV by gnotobiotic pigs can persist for at least 4 weeks.…”

Section: Discussionmentioning

confidence: 94%

The behaviour of porcine cytomegalovirus in commercial pig herds

Plowright

Edington

Watt

1976

J. Hyg.

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SUMMARYA longitudinal, virological and serological study of pigs in two herds with respiratory disease showed that infection by porcine cytomegalovirus (PCMV) was universal in both.Virus excretion usually began when piglets were between 3 and 6 weeks of age and reached a maximum between 5 and 8 weeks; it was usually no longer detectable at 11–12 weeks. Antibody demonstrable in indirect immunofluorescence (IIF) tests was present to moderate or high titre in all piglets at 2–3 weeks. This was presumed to be maternal in origin as it declined in titre between 2–3 and 5–6 weeks. After this fall the majority of piglets showed seroconversion as a result of virus infection. One group of 12 pigs in which infection occurred earlier than usual showed a very poor antibody response, which, nevertheless, persisted through to week 27.The findings are discussed with relation to porcine atrophic rhinitis and cytomegalovirus infection in other species.

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Section: Discussionmentioning

confidence: 94%

The behaviour of porcine cytomegalovirus in commercial pig herds

Plowright

Edington

Watt

1976

J. Hyg.

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“…Young adults are, therefore, apparently exposed as much to infection as school-children. It is probable that children are the main source of infection since it has been shown that they may excrete virus in their mouths, as well as in the urine, for prolonged periods (Rowe, Hartley, Cramblett & Mastrota, 1958). There is little information concerning the excretion of virus in infected adults, although it has been demonstrated that women who have given birth to babies with cytomegalic inclusion disease may continue to excrete virus in their saliva for many months without symptoms (Medearis, 1964).…”

Section: Discussionmentioning

confidence: 99%

“…Women who have produced babies with neonatal disease have sometimes given histories of respiratory illnesses during the course of pregnancy (Weller & Hanshaw, 1962;Medearis, 1964), and the almost invariable presence of lung lesions in both neonatal and adult disease stresses the importance of the respiratory site of entry of the virus. Small children with apparently symptomless excretion of cytomegalovirus in the urine may have hepatomegaly or abnormal liver function tests (Rowe et al 1958;Hanshaw & Simon, 1962). Whether this is always transient or occasionally results in more chronic liver disease is as yet unknown.…”

Section: Discussionmentioning

confidence: 99%

The incidence of infection with cytomegalovirus in a normal population: A serological study in Greater London

Stern

Elek

1965

J. Hyg.

176

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A serological study of cytomegalovirus infection in London shows it to be prevalent. Under 5 years of age only 4% of children have antibodies, but this increases to 15% by 10 years of age and 21% by 15 years. The maximum incidence of 54% is reached by 25–35 years, and this is maintained in the older age groups of the population. In two mixed day schools the incidence of infection was significantly lower than in a boarding school, suggesting that close prolonged contact is required for spread of infection.Different strains of cytomegalovirus possess common group-specific complement-fixing antigens.It is suggested that clinical disease caused by cytomegaloviruses is more frequent and more varied than previously believed, although diagnosis may be difficult without virological help.

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“…RESUMO -São apresentados os resultados de um estudo comparativo da susceptibilidade de diversas linhagens de células diplóides humanas (FH 1 , FH 3 , FH 4 , FH 11 , FH 13 , FH 14 , FH 16 ) ao vírus da citomegalia (VCM). Das linhagens referidas, tôdas se mostraram sensíveis aos vírus estudados, com exceção das linhagens FH 3 e FH 16 ; estas vieram mostrar o mesmo grau de susceptibilidade depois de várias sub-culturas, no momento em que o aspecto morfológico da camada celular passou de heterogêneo -células fibroblás-ticas e epiteliais -a homogêneo -células fibroblásticas.…”

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Estudo comparativo da susceptibilidade de linhagens de células diplóides humanas ao vírus da citomegalia (VCM)

Stewien¹

1971

Rev. Saúde Pública

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, era de se esperar um progresso rápido para um conhecimento melhor da citomegalia, a exemplo do que ocorreu com a maioria das demais viroses humanas. Entretanto, os estudos de investigação sobre a citomegalia tiveram um desenvolvimento moderado, isto certamente devido aos atributos peculiares do seu agente etiológico e das relações dêste com o hospedeiro. Assim, somente uma série de estudos sôbre as propriedades incomuns do vírus da citobegalia (VCM) e das suas relações suigeneris com as células hospedeiras, permitirá avaliar com segurança cada vez maior os resultados dos diagnósticos clí-nico-laboratoriais, bem como eliminar dificuldades práticas na elucidação do seu comportamento como agente etiológico. Êstes estudos são revestidos de importân-cia, pois, ao contrário do que anteriormente se pensava, as infecções com o ví-rus da citomegalia são freqüentes, tanto em crianças, quanto em adultos.

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Detection of Human Salivary Gland Virus in the Mouth and Urine of Children1

Cited by 47 publications

References 0 publications

The behaviour of porcine cytomegalovirus in commercial pig herds

The behaviour of porcine cytomegalovirus in commercial pig herds

The incidence of infection with cytomegalovirus in a normal population: A serological study in Greater London

Estudo comparativo da susceptibilidade de linhagens de células diplóides humanas ao vírus da citomegalia (VCM)

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