1996
DOI: 10.1016/s0025-6196(11)63001-2
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Detection of Hyperdiploid Malignant Cells in Pleural Effusions With Chromosome-Specific Probes and Fluorescence In Situ Hybridization

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Cited by 10 publications
(9 citation statements)
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“…It is notable that, in one MM case in our study, 63% of the tumor cells showed monosomy 9. Loss of both whole chromosome 9 and 9p was frequently found in previous studies of pleural effusion cells and cell lines derived from MM 35, 36…”
Section: Discussionmentioning
confidence: 64%
“…It is notable that, in one MM case in our study, 63% of the tumor cells showed monosomy 9. Loss of both whole chromosome 9 and 9p was frequently found in previous studies of pleural effusion cells and cell lines derived from MM 35, 36…”
Section: Discussionmentioning
confidence: 64%
“…By this method, the definition of a malignant sample was based purely on the percentage of hyperdiploid nuclei counted. In accordance with criteria published by Johnson et al,1 all effusions in which 8% or more of cells showed hyperdiploidy for 1 or more chromosomes were considered malignant. Hypodiploidy (monosomy) may be due to technical artefact1 or interphasic somatic pairing of homologous centromeres,6 and therefore was not used as an indicator of malignancy in this study.…”
Section: Methodsmentioning
confidence: 85%
“…When FISH is used for the detection of hyperdiploidy in solid and hematopoetic tumor systems, the conventional method is to analyze a fixed number (usually 100‐130) of interphase nuclei arbitrarily. Published studies on the utilization of FISH in the detection of hyperdiploid malignant cells in body effusions used this conventional method of analysis 1, 2. To us, this method does not appear optimal for body effusion systems because, unlike tumor systems in which all of the cells are malignant, some effusions consist of a mixed benign and malignant cell population.…”
Section: Discussionmentioning
confidence: 99%
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