Detection of influenza myocarditis using national healthcare safety network surveillance definitions accounting for fever in older adults

Datta, Rupak; Helou, Elie El; Tucker, Mollie; John, Blessy; Martinello, Richard A.; Malinis, Maricar

doi:10.1017/ice.2018.147

Cited by 5 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…Patients with influenza were more likely to have chronic heart failure at baseline, but the question of whether the incidence and the impact of seasonal influenza-related myocarditis is underestimated requires further investigation. 34 Although this study includes data collected on a national level from more than 100 000 hospitalised patients of all ages, we recognise that it has several limitations. First, the comparison between COVID-19 and seasonal influenza has some difficulties, such as possible testing biases and differences between viruses.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study

Piroth

Cottenet

Mariet

et al. 2021

The Lancet Respiratory Medicine

484

441

View full text Add to dashboard Cite

Background To date, influenza epidemics have been considered suitable for use as a model for the COVID-19 epidemic, given that they are respiratory diseases with similar modes of transmission. However, data directly comparing the two diseases are scarce.Methods We did a nationwide retrospective cohort study using the French national administrative database (PMSI), which includes discharge summaries for all hospital admissions in France. All patients hospitalised for COVID-19 from March 1 to April 30, 2020, and all patients hospitalised for influenza between Dec 1, 2018, and Feb 28, 2019, were included. The diagnosis of COVID-19 (International Classification of Diseases [10th edition] codes U07.10, U07.11, U07.12, U07.14, or U07.15) or influenza (J09, J10, or J11) comprised primary, related, or associated diagnosis. Comparisons of risk factors, clinical characteristics, and outcomes between patients hospitalised for COVID-19 and influenza were done, with data also stratified by age group. Findings 89 530 patients with COVID-19 and 45 819 patients with influenza were hospitalised in France during the respective study periods. The median age of patients was 68 years (IQR 52-82) for COVID-19 and 71 years (34-84) for influenza. Patients with COVID-19 were more frequently obese or overweight, and more frequently had diabetes, hypertension, and dyslipidaemia than patients with influenza, whereas those with influenza more frequently had heart failure, chronic respiratory disease, cirrhosis, and deficiency anaemia. Patients admitted to hospital with COVID-19 more frequently developed acute respiratory failure, pulmonary embolism, septic shock, or haemorrhagic stroke than patients with influenza, but less frequently developed myocardial infarction or atrial fibrillation. In-hospital mortality was higher in patients with COVID-19 than in patients with influenza (15 104 [16•9%] of 89 530 vs 2640 [5•8%] of 45 819), with a relative risk of death of 2•9 (95% CI 2•8-3•0) and an age-standardised mortality ratio of 2•82. Of the patients hospitalised, the proportion of paediatric patients (<18 years) was smaller for COVID-19 than for influenza (1227 [1•4%] vs 8942 [19•5%]), but a larger proportion of patients younger than 5 years needed intensive care support for COVID-19 than for influenza (14 [2•3%] of 613 vs 65 [0•9%] of 6973). In adolescents (11-17 years), the in-hospital mortality was ten-times higher for COVID-19 than for influenza (five [1•1% of 458 vs one [0•1%] of 804), and patients with COVID-19 were more frequently obese or overweight.Interpretation The presentation of patients with COVID-19 and seasonal influenza requiring hospitalisation differs considerably. Severe acute respiratory syndrome coronavirus 2 is likely to have a higher potential for respiratory pathogenicity, leading to more respiratory complications and to higher mortality. In children, although the rate of hospitalisation for COVID-19 appears to be lower than for influenza, in-hospital mortality is higher; however, low patient numbers limit this finding...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study

Piroth

Cottenet

Mariet

et al. 2021

The Lancet Respiratory Medicine

484

441

View full text Add to dashboard Cite

show abstract

“…La miocarditis es una complicación poco frecuente de la influenza, aunque con un incremento en los últimos años a partir de la pandemia por el virus de la influenza AH1N1/2009 (2), cuya verdadera incidencia puede estar siendo subestimada (19). La gran mayoría de los casos de miocarditis por influenza se relacionan con el virus de tipo A y, en menor proporción, con el de tipo B.…”

Section: Discussionunclassified

Miocarditis fulminante en adultos por el virus de la influenza B: reporte de dos casos y revisión de la literatura

Silva¹,

Montenegro²,

Estupiñán

et al. 2019

biomedica

View full text Add to dashboard Cite

La miocarditis es una enfermedad inflamatoria del miocardio. Las infecciones virales son la causa más común, aunque también puede deberse a reacciones de hipersensibilidad y de etiología autoinmunitaria, entre otras.El espectro clínico de la enfermedad es variado y comprende desde un curso asintomático, seguido de dolor torácico, arritmias y falla cardiaca aguda, hasta un cuadro fulminante.El término ‘fulminante’ se refiere al desarrollo de un shock cardiogénico con necesidad de soporte vasopresor e inotrópico o dispositivos de asistencia circulatoria, ya sea oxigenación por membrana extracorpórea o balón de contrapulsación intraaórtico.Cerca del 10 % de los casos de falla cardiaca por miocarditis corresponde a miocarditis fulminante. La miocarditis por influenza se considera una condición infrecuente; no obstante, su incidencia ha aumentado desde el 2009 a raíz de la pandemia de influenza por el virus AH1N1.Por su parte, la miocarditis por influenza de tipo B sigue siendo una condición infrecuente.Se describen aquí dos casos confirmados de miocarditis fulminante por el virus de la influenza B atendidos en un centro cardiovascular, que requirieron dispositivos de asistencia circulatoria mecánica.

show abstract

“…The 2017 National Healthcare Safety Network (NHSN) surveillance definition for myocarditis offers fair sensitivity and can be used even in resource-limited settings. Clinical features-based criteria for diagnosing myocarditis from NHSN requires (1) influenza identified from myocardial tissue or (2) ≥2 clinical features, including fever (>100.4°F), chest pain, paradoxical pulse, or increased heart size, with no other recognized cause plus ≥1 additional parameter, including an electrocardiogram (EKG) consistent with myocarditis, histological evidence of myocarditis, a four-fold rise in paired sera from the immunoglobulin G (IgG) antibody titer, or pericardial effusion [ 21 ]. Direct myocardial injury by the influenza virus and host cell immunity like increased expression of trypsin, matrix metalloproteinases, and cytokines like tumor necrosis factor (TNF) are thought to be the cause of influenza myocarditis and its complications but still the pathogenesis is largely unknown [ 18 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Influenza Myocarditis: A Literature Review

Baral¹,

Adhikari²,

Adhikari³

et al. 2020

Cureus

View full text Add to dashboard Cite

Detection of influenza myocarditis using national healthcare safety network surveillance definitions accounting for fever in older adults

Cited by 5 publications

References 9 publications

Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study

Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study

Miocarditis fulminante en adultos por el virus de la influenza B: reporte de dos casos y revisión de la literatura

Influenza Myocarditis: A Literature Review

Contact Info

Product

Resources

About