Detection of Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among Bisphenol a Exposed Workers.

Abstract

Introduction: Many previous studies suggested that bisphenol A (BPA) exposure could trigger insulin resistance (IR) and elevate the risk to develop type 2 diabetes mellitus (T2DM). Aim of work: This research was done to detect IR prevalence and risk to develop T2DM among non-diabetic BPA exposed workers involved in the plastic industry. Materials and Methods: This work was conducted in a factory for manufacturing polyvinyl chloride (PVC) pipes present in the 10 th of Ramadan City, Egypt. The study population involved an exposed group of 44 non-diabetic workers occupationally-exposed to the plastics manufacturing process and a control group of 46 non-diabetic matching administrative subjects. Full medical and occupational histories in addition to clinical examination, were done. Fasting serum samples were used to measure adiponectin, insulin, lipid parameters: Total cholesterol (TC), Triglycerides (TG), Low-density lipoproteins (LDL), and High-density lipoproteins (HDL) and BPA levels. Insulin resistance was evaluated using homeostasis model assessment of insulin resistance (HOMA-IR). Results: The study showed a statistically increase in the levels of BPA, insulin, TC, TG and LDL, in addition to HOMA-IR indices, and a statistically decrease in the levels of adiponectin and HDL among BPA exposed workers compared to the control group. All measured parameters of IR were correlated with each other, with the BPA levels, and with the duration of occupational exposure among the exposed workers. Conclusion:Long-term occupational exposure to BPA in the plastic industry is accompanied by an elevated risk of developing IR and hence T2DM.