Detection of interstitial pneumonia with autoimmune features and idiopathic pulmonary fibrosis are enhanced by involvement of matrix metalloproteinases levels and clinical diagnosis

Abstract

Background: Higher detection of interstitial pneumonia with autoimmune features (IPAF), idiopathic pulmonary brosis (IPF) has signi cant diagnostic and therapeutic implications. Some MMPs have been reliable diagnostic biomarkers in IPAF and IPF in previous studies, yet relevant reliability remains to be recognized. Material and Methods: 36 ILD patients, including 31 IPAF patients (Mean ± SD, 50.20 ± 5.10 years; 16 (51.6%) females) and 5 IPF patients (Mean ± SD, 61.20 ± 6.73 years; 1 (20.0%) females) were retrospectively enrolled. Serial serum samples were collected from corresponding patients between January 2019 and December 2020. Notably, Serum MMPs levels were measured by U-PLEX Biomarker Group 1(Human) Multiplex Assays (MSD, USA).Results: A combination of MMPs, combinatorial biomarkers and was strongly associated with the above clinical subjects (AUC, 0.597 for Stability vs. Improvement and 0.756 for Stability vs. Exacerbation).Importantly, the AUC of MMP-12 reaches 0.730 (P<0.05, Stability AUC vs. Improvement AUC) while MMP-13 reaches 0.741 (P<0.05, Stability AUC vs. Exacerbation AUC) showed better academic performance than other MMPs in two comparisons.Conclusions: Clinical risk factors and MMPs are strongly associated with either strati cation of the degree of disease of progression of IPAF or in two IPAF and IPF independent cohorts. To our knowledge, this is the rst to illustrate that MMP-12 and MMP-13 may be expected to become typical promising biomarkers in Improvement -IPAF and Exacerbation -IPAF, respectively.

The effects of lipoic acid on respiratory diseases

“…Recent studies have demonstrated that matrix metalloproteinases (MMPs), which are pivotal proteolytic enzymes, are involved in pathological and inflammatory processes in several respiratory diseases, such as interstitial pneumonia [237] , pulmonary fibrosis [238] , and COPD [239] . In particular, MMP-1, MMP-2, MMP-8, and TIMP-1 have been demonstrated in experimental and clinical research to influence inflammation [240] , [241] , [242] .…”

“…In particular, MMP-1, MMP-2, MMP-8, and TIMP-1 have been demonstrated in experimental and clinical research to influence inflammation [240] , [241] , [242] . These factors may even be expected to become promising typical biomarkers to detect the severity of some lung diseases [238] . Ceylanlı et al [243] found that LA could suppress MMP-1, MMP-2, MMP-8, tissue inhibitors of metalloproteinase-1 (TIMP-1), TNF-α, IL-1, and MDA expression, thereby attenuating 5-fluorouracil (5-FU)-induced gastrointestinal mucositis in rats.…”