Detection of laminar resorption in osteo-odonto-keratoprostheses

Avadhanam, Venkata; Smith, J. A.; Poostchi, Ali; Chervenkoff, Jordan V.; Raqqad, Nancy Al; Francis, I R; Liu, Christopher S.

doi:10.1016/j.jtos.2018.09.004

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…It seems the best way forward is to implement both methods in the long-term. However, frequent CT scanning is not indicated for the detection of laminar resorption ( 85 ).…”

Section: Hard Keratoprosthesesmentioning

confidence: 99%

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Artificial Cornea: Past, Current, and Future Directions

et al. 2021

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Corneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal blindness but often fails those with high-risk indications such as recurrent or chronic inflammatory disorders, history of glaucoma and herpetic infections, and those with neovascularisation of the host bed. Moreover, the need for donor corneas greatly exceeds the supply, especially in disadvantaged countries. Therefore, artificial and bio-mimetic corneas have been investigated for patients with indications that result in keratoplasty failure. Two long-lasting keratoprostheses with different indications, the Boston type-1 keratoprostheses and osteo-odonto-keratoprostheses have been adapted to minimise complications that have arisen over time. However, both utilise either autologous tissue or an allograft cornea to increase biointegration. To step away from the need for donor material, synthetic keratoprostheses with soft skirts have been introduced to increase biointegration between the device and native tissue. The AlphaCor™, a synthetic polymer (PHEMA) hydrogel, addressed certain complications of the previous versions of keratoprostheses but resulted in stromal melting and optic deposition. Efforts are being made towards creating synthetic keratoprostheses that emulate native corneas by the inclusion of biomolecules that support enhanced biointegration of the implant while reducing stromal melting and optic deposition. The field continues to shift towards more advanced bioengineering approaches to form replacement corneas. Certain biomolecules such as collagen are being investigated to create corneal substitutes, which can be used as the basis for bio-inks in 3D corneal bioprinting. Alternatively, decellularised corneas from mammalian sources have shown potential in replicating both the corneal composition and fibril architecture. This review will discuss the limitations of keratoplasty, milestones in the history of artificial corneal development, advancements in current artificial corneas, and future possibilities in this field.

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“…It seems the best way forward is to implement both methods in the long-term. However, frequent CT scanning is not indicated for the detection of laminar resorption ( 85 ).…”

Section: Hard Keratoprosthesesmentioning

confidence: 99%

“…There is uncertainty around the ability of bisphosphonate drugs such as alendronate to decelerate laminar resorption. Several remedies are available that maintain mucosal health and in addition, smoking cessation can have an increased benefit ( 85 ).…”

Section: Hard Keratoprosthesesmentioning

confidence: 99%