Detection of local recurrence of soft-tissue sarcoma with positron emission tomography using [18F]fluorodeoxyglucose

Kole, AC; Nieweg, OE; vanGinkel, RJ; Pruim, Jan; Hoekstra, HJ; Paans, Amj; Vaalburg, W; Koops, H. Schraffordt

doi:10.1007/bf02316811

Cited by 96 publications

(20 citation statements)

References 21 publications

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“…10 -13,34 To improve the accuracy of the detection of local sarcoma recurrence, FDG-PET has been proposed as adjunct to MRI (sensitivity 83%) and CT (sensitivity 58%). 35 We found FDG-PET to be very sensitive for detecting high-and intermediate-grade local recurrences (all lesions depicted). Moreover, 12 of 13 masses that could not be determined as either local recurrences or benign changes based on radiologic tomography were accurately differentiated by FDG-PET.…”

Section: Discussionmentioning

confidence: 99%

“…Our results confirm the observations by others in 17 patients evaluated with quantitative FDG-PET (sensitivity 93%, specificity 94%). 35 In a retrospective analysis using whole-body FDG-PET, a specificity of 94% and a sensitivity of 74% for the detection of local failure (n ϭ 19) were observed. 36 The lower sensitivity found in that study might be explained by the retrospective design, the lower resolution of whole-body PET, and the lack of quantitative measurements.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Value of [18-F] Fluorodeoxyglucose Positron Emission Tomography Imaging in Soft Tissue Sarcomas

Schwarzbach¹,

Dimitrakopoulou-Strauß²,

Willeke³

et al. 2000

Annals of Surgery

166

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical Value of [18-F] Fluorodeoxyglucose Positron Emission Tomography Imaging in Soft Tissue Sarcomas

Schwarzbach¹,

Dimitrakopoulou-Strauß²,

Willeke³

et al. 2000

Annals of Surgery

166

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“…During the last decade, the value of positron emission tomography (PET) in STS with several tracers, especially [ 18 F]fluoro-2Ј-deoxy-Dglucose (FDG), has been investigated (10 -16). However, the current potential of FDG-PET in the detection and/or grading is still unknown (10,11,15,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

Detection and Grading of Soft Tissue Sarcomas of the Extremities with 18F-3′-Fluoro-3′-Deoxy-l-Thymidine

Cobben

Elsinga

Suurmeijer

et al. 2004

Clinical Cancer Research

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Purpose: The aim of the study was to investigate the feasibility of 18 F-3-fluoro-3-deoxy-L-thymidine positron emission tomography (FLT-PET) for the detection and grading of soft tissue sarcoma (STS).Experimental Design: Nineteen patients with 20 STSs of the extremities were scanned, using attenuation corrected whole-body FLT-PET. Standardized uptake values (SUVs) and tumor:nontumor ratios (TNTs) were compared with histopathological parameters using French and Japanese grading systems.Results: Mean SUV, maximal SUV, and TNT could differentiate between low-grade (grade 1; n ‫؍‬ 6) STS and high-grade (grade 2 and 3; n ‫؍‬ 14) STS according to the French grading system (P ‫؍‬ 0.001). Mean SUV, max SUV, and TNT correlated with mitotic score, MIB-1 score, the French and Japanese grading system (• ‫؍‬ 0.550 -0.747).Conclusions: FLT-PET is able to visualize STS and differentiate between low-grade and high-grade STS. The uptake of FLT correlates with the proliferation of STS.

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“…La propension de ces tumeurs à récidiver même après 10 ans incite à proposer une surveillance à très long terme. L'utilisation de la TEP dans la détection des récidives a été décrite et donne des résultats encourageants 24 .…”

Section: Tumeurs Rétropéritonéales Primitivesunclassified

Tumeurs rétropéritonéales primitives : Profils diagnostique, thérapeutique et anatomopathologique

Aitsakel

Elsayegh

Benslimane

et al. 2015

CUAJ

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RésuméIntroduction : Les tumeurs rétropéritonéales forment un groupe hétérogène de tumeurs rares (< 1 % de toutes les tumeurs), dont 80 % sont malignes. Leur identification et la connaissance de leur pronostic sont les conditions essentielles à leur prise en charge thérapeutique. Le diagnostic positif était fait par TDM abdomino-pelvienne. Le traitement était surtout chirurgical, visant l'exérèse complète de la masse tumorale, avec ou sans thérapie adjuvante (radiothérapie, chimiothérapie) selon l'analyse histologique. Les tumeurs mésoder-miques sont les plus fréquentes (63,6 % ; n = 5) : deux liposarcomes (18 %), deux lymphomes malins (18 %), un hémangiopéricytome (9 %), un léiomyosarcome (9 %), et un cas de rhabdomyosarcome (9 %). Le taux de tumeurs ectodermiques était de 27,4 % (n = 3) ; il s'agit de deux cas de schwannome (18 %) et un cas de ganglioneuroblastome (9 %). Aucune tumeur vestigiale, contre un cas de tumeur pseudo-inflammatoire (9 %). Une évolution favorable a été obervée chez près de la moitié des patients (40 %); on a noté quatre cas de récidive, trois cas de patients perdus de vue, et un décès. Conclusion : Dans notre série, les tumeurs mésodermiques malignes restent les plus fréquentes, sans prédominance d'âge et de sexe. Les tumeurs rétropéritonéales gardent un pronostic sombre, étant donné que nos patients sont vus à un stade tardif, et aussi du fait du potentiel malin et récidivant de ces tumeurs.

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Detection of local recurrence of soft-tissue sarcoma with positron emission tomography using [18F]fluorodeoxyglucose

Abstract: PET with FDG is a useful addition to the diagnostic armamentarium for detecting local recurrence of soft-tissue sarcomas and provides an indication of the malignancy grade of the recurrent lesion.

Cited by 96 publications

References 21 publications

Clinical Value of [18-F] Fluorodeoxyglucose Positron Emission Tomography Imaging in Soft Tissue Sarcomas

Clinical Value of [18-F] Fluorodeoxyglucose Positron Emission Tomography Imaging in Soft Tissue Sarcomas

Detection and Grading of Soft Tissue Sarcomas of the Extremities with 18F-3′-Fluoro-3′-Deoxy-l-Thymidine

Tumeurs rétropéritonéales primitives : Profils diagnostique, thérapeutique et anatomopathologique

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