Detection of local tissue alteration during retinal laser photocoagulation of ex vivo porcine eyes using phase-resolved optical coherence tomography

Makita, Shuichi; Yasuno, Yoshiaki

doi:10.1364/boe.8.003067

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…A phase stability of 4.2 mrad was obtained, and the feasibility and performance of our SS-OCE CP were tested and validated using a phantom and in vivo rabbit model. This highly phase-stable system can quantify displacement in the subnanometre range, and we believe that it has great potential in other applications that require precision phase measurement, such as flowmetry 11 , vibrometry 43 , and molecular imaging 44 .…”

Section: Discussionmentioning

confidence: 98%

Ultrahigh-sensitive optical coherence elastography

Moon

Chen

et al. 2020

Light Sci Appl

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The phase stability of an optical coherence elastography (OCE) system is the key determining factor for achieving a precise elasticity measurement, and it can be affected by the signal-to-noise ratio (SNR), timing jitters in the signal acquisition process, and fluctuations in the optical path difference (OPD) between the sample and reference arms. In this study, we developed an OCE system based on swept-source optical coherence tomography (SS-OCT) with a common-path configuration (SS-OCE CP). Our system has a phase stability of 4.2 mrad without external stabilization or extensive post-processing, such as averaging. This phase stability allows us to detect a displacement as small as 300 pm. A common-path interferometer was incorporated by integrating a 3-mm wedged window into the SS-OCT system to provide intrinsic compensation for polarization and dispersion mismatch, as well as to minimize phase fluctuations caused by the OPD variation. The wedged window generates two reference signals that produce two OCT images, allowing for averaging to improve the SNR. Furthermore, the electrical components are optimized to minimize the timing jitters and prevent edge collisions by adjusting the delays between the trigger, k-clock, and signal, utilizing a high-speed waveform digitizer, and incorporating a high-bandwidth balanced photodetector. We validated the SS-OCE CP performance in a tissue-mimicking phantom and an in vivo rabbit model, and the results demonstrated a significantly improved phase stability compared to that of the conventional SS-OCE. To the best of our knowledge, we demonstrated the first SS-OCE CP system, which possesses high-phase stability and can be utilized to significantly improve the sensitivity of elastography.

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Section: Discussionmentioning

confidence: 98%

Ultrahigh-sensitive optical coherence elastography

Moon

Chen

et al. 2020

Light Sci Appl

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“…Doppler imaging and phase-sensitive OCT angiography techniques are promising OCT derivatives that rely on phase measurement capabilities [8][9][10][11][12]. Sensitive measurement of signal phase can also allow precision elastography [13,14], vibrometry [15], molecular imaging [16,17] and other functional imaging modalities. However, SS-OCT has been regarded less stable in phase measurement than the SD-OCT counterpart because of the inherent instabilities of swept sources.…”

Section: Introductionmentioning

confidence: 99%

Phase-stability optimization of swept-source optical coherence tomography

Moon¹,

Chen²

2018

Biomed. Opt. Express

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Phase-resolved imaging of swept-source optical coherence tomography (SS-OCT) is subject to phase measurement instabilities involved with the sweep variation of a frequency-swept source. In general, optically generated timing references are utilized to track the variations imposed on OCT signals. But they might not be accurately synchronized due to relative time delays. In this research, we investigated the impact of the signal delays on the timing instabilities and the consequent deviations of the measured phases. We considered two types of timing signals utilized in a popular digitizer operation mode: a sweep trigger from a fiber Bragg grating (FBG) that initiates a series of signal sampling actions clocked by an auxiliary Mach-Zehnder interferometer (MZI) signal. We found that significant instabilities were brought by the relative delays through incoherent timing corrections and timing collisions between the timing references. The best-to-worst ratio of the measured phase errors was higher than 200 while only the signal delays varied. Noise-limited phase stability was achieved with a wide dynamic range of OCT signals above 50 dB in optimized delays. This demonstrated that delay optimization is very effective in phase stabilization of SS-OCT.

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Long-term vision outcomes for patients with albinism and diabetic retinopathy

Murphy

Katta

Egan

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Not required because this is a retrospective study using data collected as part of the patient's routine clinical care. Consent to participateNot required because this is a retrospective study using data collected as part of the patient's routine clinical care. Consent for publicationNot required because this is a retrospective study using data collected as part of the patient's routine clinical care. DeclarationsNo authors have any declarations to make. 4 Key messages 1. Albinism defines a group of genetic diseases characterised by depigmentation of the hair, skin and eyes in oculocutaneous albinism or isolated to the eyes in ocular albinism 2. Treating proliferative diabetic retinopathy in patients with ocular/oculocutaneous albinism may be more difficult due to potential challenges in identifying retinal vascular diseases and impaired efficacy of laser treatments 3. Despite extensive intervention, proliferative diabetic retinopathy is associated with poor long-term vision for patients with albinism.4. Individuals without evidence of proliferative diabetic retinopathy appear to maintain stable vision so disease prevention is paramount

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Detection of local tissue alteration during retinal laser photocoagulation of ex vivo porcine eyes using phase-resolved optical coherence tomography

Cited by 6 publications

References 24 publications

Ultrahigh-sensitive optical coherence elastography

Ultrahigh-sensitive optical coherence elastography

Phase-stability optimization of swept-source optical coherence tomography

Long-term vision outcomes for patients with albinism and diabetic retinopathy

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