2020
DOI: 10.1038/s41377-020-0297-9
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Ultrahigh-sensitive optical coherence elastography

Abstract: The phase stability of an optical coherence elastography (OCE) system is the key determining factor for achieving a precise elasticity measurement, and it can be affected by the signal-to-noise ratio (SNR), timing jitters in the signal acquisition process, and fluctuations in the optical path difference (OPD) between the sample and reference arms. In this study, we developed an OCE system based on swept-source optical coherence tomography (SS-OCT) with a common-path configuration (SS-OCE CP). Our system has a … Show more

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Cited by 46 publications
(34 citation statements)
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“…However, despite the lower image resolution, the OPE method can achieve an axial displacement sensitivity at 10s of nanometers, 2 , 50 approaching that of OCEs (a few to 10s of nanometers or better with advanced systems). 44 , 51 During data acquisition, the corneal stroma was placed between 4.5 and 5 mm depth to ensure that it falls within the elevational and the lateral focus of the transducer. The larger image thickness of the Vevo2100 system (i.e.…”
Section: Discussionmentioning
confidence: 99%
“…However, despite the lower image resolution, the OPE method can achieve an axial displacement sensitivity at 10s of nanometers, 2 , 50 approaching that of OCEs (a few to 10s of nanometers or better with advanced systems). 44 , 51 During data acquisition, the corneal stroma was placed between 4.5 and 5 mm depth to ensure that it falls within the elevational and the lateral focus of the transducer. The larger image thickness of the Vevo2100 system (i.e.…”
Section: Discussionmentioning
confidence: 99%
“…The potential of the common path approach has also been realized for the optical coherence elastography applications and benchtop [35][36][37] as well as fiber-based [38][39][40][41] common-path OCE systems have been reported. In clinical settings, fiber-based common path probes for elastography are preferred over their free space counterparts because of their lightweight and ease of handling.…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, Zhang et al [146] developed a combined IVPA and autofluorescence imaging system, which is able to detect lipid core and intraplaque hemorrhage simultaneously. Optical coherence elastography (OCE) can resolve a localized displacement in subnanometers and is therefore ideal for studying the elasticity of biological tissue, which can be incorporated into PA imaging to enable simultaneous visualization of morphology, molecular contrast, and biomechanical properties to further improve diagnostic outcome [121,147,148].…”
Section: Discussionmentioning
confidence: 99%