“…However, several studies described an appropriate reference standard that included histopathology with either clinical follow-up or cancer registry matching to ascertain outcomes [9,14,16,18,21,28,31]. Studies proposed to develop and/or evaluate AI models or techniques for breast cancer detection [9,11,18,21,22,27,28,26], or for diagnosis (classification) or interpretation of mammographic examinations [13,14,15,16,20,[23][24][25]30], or dealt with advancing computer-aided detection (CAD) systems through new AI models [10,12,17,19,29]; and one study investigated AI for discrimination between benign and cancerous lesions jointly with cancer risk prediction [31]. Rodriguez-Ruiz et al [9] reported a multi-reader study comparing an AI system with radiologists' interpretation of various datasets of screening and clinical mammographic examinations.…”