Detection of Methicillin Resistant, ESBL and Amp C Producing Uropathogens from a Tertiary Care Hospital in North India

Antibiotic susceptibility patterns of Uropathogenic Escherichia coli among patients with urinary tract infections in a tertiary care hospital in Maiduguri, North Eastern, Nigeria

“…These antibiotics susceptibility results correlate with other studies (Uwaezuoke and Ogbulie, 2006;Salas, 2011;Akoachere et al, 2012;Tansarli et al, 2013;Nzalie et al, 2016). Contrary to these findings were reports made by Rangari et al (2015) and Jeevan and Zarrin (2017) documenting low susceptibility to these drugs. The reason for the moderate susceptibility recorded to these agents supports earlier documentation by Abdu and Lamikanra (2016); that the aminoglycosides (Gentamycin and Streptomycin) appears to be infrequently used as they are administered parenterally, a dosage form which is far less amenable to self-medication than orally administered antibiotics in this locality, while, the reason given by Swartz (1997) that the activity of Gentamicin against all the isolates may be due to its widespread use in the hospital environment as a broadspectrum antibiotic and the use especially when only one type is employed, may lead to an increased level of resistance.…”

“…This underscores the fact that many studies have reported highly resistant and have recommended the disbandment of its use as the drug of choice for empirical treatment of UTI management globally. For instance, high rate of resistance against Cotrimoxazole was reported by studies done in India, Brazil, and Iran (Prakash and Saxena, 2013;Jeevan and Zarrin, 2017;Peixoto De Miranda et al, 2014;Rocha et al, 2012;Aghazadeh et al, 2015) and also by other studies done in Ethiopia (Derbie et al, 2017). Nonetheless, reduced susceptibility of E. coli isolates from patients with UTI to Co-trimoxazole varying from (0.00% susceptibility) to (13.90% susceptibility) have been reported by other studies done in different part of Nigeria (Ochada et al, 2014;Oreh and Attama, 2013;Dada-Adegbola and Muili, 2010;Uwaezuoke and Ogbulie, 2006).…”