Detection of microplastics in patients with allergic rhinitis

Tuna, Ayşegül; Taş, Burak Mustafa; Kankılıç, Gökben Başaran; Koçak, Furkan Melih; Şencan, Ziya; Cömert, Ela; Muluk, Nuray Bayar; Kaçmaz, Birgül; Gül, Serdar; BÖKE, Eftal

doi:10.1007/s00405-023-08105-7

Cited by 13 publications

(1 citation statement)

References 21 publications

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“…It remains to be studied how these levels of microplastics relate to the levels in bronchoalveolar lavage fluid of healthy controls. However, in nasal lavages of healthy volunteers, fewer microplastics were detected than in nasal lavages of patients with allergic rhinitis, a disease often associated with allergic asthma [ 114 ].…”

Section: Asthma and Allergic Rhinitismentioning

confidence: 99%

Microplastic and plastic pollution: impact on respiratory disease and health

Vasse,

Melgert

2024

Eur Respir Rev

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Throughout their lifecycle, from production to use and upon disposal, plastics release chemicals and particles known as micro- and nanoplastics (MNPs) that can accumulate in the environment. MNPs have been detected in different locations of the human body, including in our lungs. This is likely a consequence of MNP exposure through the air we breathe. Yet, we still lack a comprehensive understanding of the impact that MNP exposure may have on respiratory disease and health. In this review, we have collated the current body of evidence on the implications of MNP inhalation on human lung health fromin vitro,in vivoand occupational exposure studies. We focused on interactions between MNP pollution and different specific lung-resident cells and respiratory diseases. We conclude that it is evident that MNPs possess the capacity to affect lung tissue in disease and health. Yet, it remains unclear to which extent this occurs upon exposure to ambient levels of MNPs, emphasising the need for a more comprehensive evaluation of environmental MNP exposure levels in everyday life.

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Section: Asthma and Allergic Rhinitismentioning

confidence: 99%

Microplastic and plastic pollution: impact on respiratory disease and health

Vasse,

Melgert

2024

Eur Respir Rev

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Microplastics in the Olfactory Bulb of the Human Brain

Amato-Lourenço,

Dantas,

Júnior

et al. 2024

JAMA Netw Open

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ImportanceMicroplastic (MP) pollution is an emerging environmental and health concern. While MPs have been detected in various human tissues, their presence in the human brain has not been documented, raising important questions about potential neurotoxic effects and the mechanisms by which MPs might reach brain tissues.ObjectiveTo determine the presence of MPs in the human olfactory bulb and to analyze their characteristics such as size, morphology, color, and polymeric composition.Design, Setting, and ParticipantsThis case series study used a cross-sectional design involving the analysis of olfactory bulb tissues obtained from deceased individuals during routine coroner autopsies. The sampling procedures were conducted at São Paulo City Death Verification Service, with laboratory analysis carried out at the Brazilian Synchrotron Light Laboratory (LNLS). Participants included 15 adult individuals who had been residents of São Paulo for more than 5 years and underwent coroner autopsies. Exclusion criteria included previous neurosurgical interventions. Data analysis was performed in April 2024.ExposureThe primary exposure assessed was the presence of MPs in the olfactory bulb, analyzed through direct tissue examination and digested tissue filtration followed by micro-Fourier transform infrared spectroscopy.Main Outcomes and MeasuresThe main outcomes were the identification and characterization of MPs within the olfactory bulb, including their size, morphology, color, and polymeric composition.ResultsThe median age of the 15 deceased individuals was 69.5 years, ranging from 33 to 100 years, with 12 males and 3 females. MPs were detected in the olfactory bulbs of 8 out of 15 individuals. A total of 16 synthetic polymer particles and fibers were identified, with 75% being particles and 25% being fibers. The most common polymer detected was polypropylene (43.8%). Sizes of MPs ranged from 5.5 μm to 26.4 μm for particles, and the mean fiber length was 21.4 μm. Polymeric materials were absent in procedural blank and negative control filters, indicating minimal contamination risk.Conclusions and RelevanceThis case series provides evidence of MPs found in the human olfactory bulb, suggesting a potential pathway for the translocation of MPs to the brain. The findings underscore the need for further research on the health implications of MP exposure, particularly concerning neurotoxicity and the potential for MPs to bypass the blood-brain barrier.

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