Detection of microvascularization of thyroid carcinomas using linear high resolution contrast-enhanced ultrasonography (CEUS)

Hornung, Matthias; Jung, Ernst Michael; Georgieva, M; Stroszczynski, Christian; Agha, Ayman

doi:10.3233/ch-2012-1597

Cited by 29 publications

(22 citation statements)

References 14 publications

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“…Blood vessels are relatively dense in marginal areas but are sparse in central areas. Differences in vascular density between marginal and central areas may cause concentric enhancement, in accordance with the results reported by Hornung et al (2012) that the AUC of the TIC of the contrast agent in the marginal zone of the nodules was higher than that in the central area. Because of the arteriovenous fistula in malignant nodules, the contrast agent washed out earlier.…”

Section: Discussionsupporting

confidence: 91%

Value of Contrast-Enhanced Ultrasound and Acoustic Radiation Force Impulse Imaging for the Differential Diagnosis of Benign and Malignant Thyroid Nodules

Wang

Qiao

et al. 2018

Front. Pharmacol.

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Objectives: To assess the value of contrast-enhanced ultrasound (CEUS) and acoustic radiation force impulse (ARFI) imaging for the differential diagnosis of benign and malignant thyroid nodules.Methods: CEUS was performed in eighty-eight thyroid nodules. The patterns of CEUS were analyzed, and ARFI was then performed. The shear wave velocities (SWVs) of the nodules and the surrounding normal thyroid tissue were obtained. The areas under the curve (AUCs) and cut-off value were obtained by a receiver operating characteristic (ROC) curve analysis. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic rate of each modality were assessed and compared using pathological diagnosis.Results: Among 88 nodules, 29 nodules were malignant and 59 were benign. The sensitivity, specificity, PPV, NPV, and diagnostic rate of CEUS were 79.3, 91.5, 82.1, 90, and 87.5%, respectively. Using a cut-off value of 2.565 m/s for SWV, the sensitivity, specificity, PPV, NPV and diagnostic rate for malignancy were 75.9, 94.9, 88.0, 88.9, and 88.6%, respectively. The AUC was 0.878. The sensitivity, specificity, PPV, NPV and diagnostic rate of CEUS in combination with ARFI were 93.1, 89.8, 81.8, 96.3, and 90.9%, respectively.Conclusion: Both CEUS and ARFI are valuable for the differential diagnosis of benign and malignant thyroid nodules. Combining these two methods can improve the diagnostic rate.

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Section: Discussionsupporting

confidence: 91%

Value of Contrast-Enhanced Ultrasound and Acoustic Radiation Force Impulse Imaging for the Differential Diagnosis of Benign and Malignant Thyroid Nodules

Wang

Qiao

et al. 2018

Front. Pharmacol.

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“…The microvessel density of malignant nodules is reported to be far behind that of benign nodules. 18 Therefore, in this study, we used quantitative parameters, including peak intensity, ascend slope, descend slope, AUC, time to peak, and time from peak to onehalf. There were significant differences between benign Combination of the nodule values of all 6 quantitative contrast-enhanced US parameters.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Efficiency of Quantitative Contrast‐Enhanced Ultrasound Indicators for Discriminating Benign From Malignant Solid Thyroid Nodules

Zhang

Zhou

et al. 2017

J of Ultrasound Medicine

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“…In several PTMC nodules, a lack of blood supply was observed as only dot-like or sporadic-like enhancement after SonoVue was administered; however, the evidence of enhancement and rapid wash-out time during the CEUS process was not easily apparent. This may be attributed to the small size of the nodules (diameter, ≤5 mm), which fail to form the tumor vascular beds and arteriovenous fistulas required to provide sufficient blood supply to the papillary thyroid carcinoma ( 17 ). However, the recording of enhancement may be influenced by the condition of the apparatus and the experience of the operator, as evidence of enhancement can be missed and be recorded as having no change in the nodule enhancement and wash-out times.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of contrast-enhanced ultrasound in papillary thyroid microcarcinoma

Chen

Liu

Zhu

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the present study was to explore the value and characteristics of contrast-enhanced ultrasound (CEUS) in the diagnosis of papillary thyroid microcarcinoma (PTMC). By analyzing CEUS information of 130 nodules obtained from 106 patients with PTMC, who had been diagnosed by surgery and pathological analysis, CEUS characteristics of PTMC nodules were concluded. Based on the results, the PTMC nodules were divided into three groups as follows: 32 nodules (24.62%) were found to be enhanced earlier than the surrounding normal thyroid tissue, 95 nodules (73.08%) were enhanced at the same time as the normal thyroid tissue and 3 nodules (2.30%) were enhanced later than the normal thyroid tissue. The results also demonstrated that the peak enhancement intensity of the 130 nodules was lower compared with the irregular intensity of the normal parenchyma in corresponding thyroids, and that PTMC enhancement washed out faster than in normal thyroid parenchyma. In conclusion, the PTMC characteristics that CEUS can detect may improve the diagnostic accuracy and provide valuable information for the treatment of the disease.

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Detection of microvascularization of thyroid carcinomas using linear high resolution contrast-enhanced ultrasonography (CEUS)

Cited by 29 publications

References 14 publications

Value of Contrast-Enhanced Ultrasound and Acoustic Radiation Force Impulse Imaging for the Differential Diagnosis of Benign and Malignant Thyroid Nodules

Value of Contrast-Enhanced Ultrasound and Acoustic Radiation Force Impulse Imaging for the Differential Diagnosis of Benign and Malignant Thyroid Nodules

Diagnostic Efficiency of Quantitative Contrast‐Enhanced Ultrasound Indicators for Discriminating Benign From Malignant Solid Thyroid Nodules

Diagnostic value of contrast-enhanced ultrasound in papillary thyroid microcarcinoma

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