Detection of Mycobacterium gilvum first time from the bathing water of leprosy patient from Purulia, West Bengal

Lavania, Mallika; Turankar, Ravindra P.; Singh, Itu; Nigam, A. N.; Sengupta, Utpal

doi:10.1016/j.ijmyco.2014.10.005

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…We suggest that M. gilvum is likely to be ubiquist with a widespread occurrence in the environment, 7,8 including being associated with human infections. While M. gilvum was until now believed to be nonpathogenic, 5,7 it has been proposed to act as an immunomodulator of the host immune system towards susceptibility of other mycobacteria such as M. leprae 7 . We did find co‐infections (presence of several mycobacteria) in a couple of BU biopsies but our results raise the possibility of M. gilvum being infectious to humans on its own.…”

Section: No Date Of Diagnosis Clinical Aspect Of the Skin Lesion Is2mentioning

confidence: 92%

“…In FG, we also found M. gilvum in sediments (11 of 12 sites) and water (seven of 12 sites) from rural and urban environments (unpublished data). We suggest that M. gilvum is likely to be ubiquist with a widespread occurrence in the environment, 7,8 including being associated with human infections. While M. gilvum was until now believed to be nonpathogenic, 5,7 it has been proposed to act as an immunomodulator of the host immune system towards susceptibility of other mycobacteria such as M. leprae 7 .…”

Section: No Date Of Diagnosis Clinical Aspect Of the Skin Lesion Is2mentioning

confidence: 92%

“…Here for the first time, we found that 50% of skin lesions clinically compatible with BU in FG were underpinned by M. gilvum rather than the expected MU. M. gilvum is a fast‐growing microorganism that was found in sputum samples, 5 pulmonary tuberculosis infections in Brazil 6 and in bathing water of patients with leprosy in West Bengal 7 . Also, M. gilvum has been isolated from river sediments based on its ability to degrade polycyclic aromatic hydrocarbons, such as pyrene, as growth substrate 8 .…”

Section: No Date Of Diagnosis Clinical Aspect Of the Skin Lesion Is2mentioning

confidence: 99%

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Are all Buruli ulcers caused by Mycobacterium ulcerans ?

et al. 2020

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normal functioning (Quality of life). People with LS reported problems with dyspareunia, physical inability to engage in intercourse due to narrowing of the vaginal opening, and lack of sexual drive from loss of sensation. They referred to the emotional impact on relationships as well as their own psychosocial-sexual wellbeing (Sexual dysfunction). Responses placed greater significance on the changes related to anatomical structure (229 responses) than on variations in cosmetic appearance (70 responses) (Appearance). Many participants described fear of potential progression to malignancy and irreversible stenosis (Progression of the condition). The importance of better awareness of LS among the general public and doctors was highlighted to aid earlier diagnosis and prevention of scarring. Many patients called for treatment that quickly resolves symptoms, reduces flare-ups and is easier to use than the standard first-line therapy of topical steroids (Management of the condition). The six key themes/domains identified above will inform the first stage of development for a LS core outcome set through the CORALS (Core Outcomes for ReseArch in LS) initiative. 8 The first stage will obtain international consensus on core outcome domains via an electronic-Delphi exercise. Subsequent work to identify appropriate outcome measurement instruments will then be needed to use in the final core outcome set. Although CORALS is intended for use in randomized trials, we believe that understanding these outcomes of importance is valuable for managing LS in the outpatient clinic. Ensuring that these issues are addressed during the consultation will benefit patient experience and overall quality of care.

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Section: No Date Of Diagnosis Clinical Aspect Of the Skin Lesion Is2mentioning

confidence: 92%

Section: No Date Of Diagnosis Clinical Aspect Of the Skin Lesion Is2mentioning

confidence: 92%

Section: No Date Of Diagnosis Clinical Aspect Of the Skin Lesion Is2mentioning

confidence: 99%

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Are all Buruli ulcers caused by Mycobacterium ulcerans ?

et al. 2020

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“…M. gilvum has rarely been isolated as an opportunistic pathogen [69] and is viewed as a nontuberculous mycobacterium and as nonpathogenic and found in water and humans [71]. Its presence has been detected in accumulated water associated with a bathing place for leprosy patients [72].…”

Section: Mycobacterium Gilvummentioning

confidence: 99%

Metagenomic Research of Infectious Diseases in Archaeological Contexts: Evidence from the Hospital Real de Todos-os-Santos (Portugal)

et al. 2022

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Syphilis is one of the most exciting diseases explored in paleopathology and, therefore, tracing back its origin and development has provided a prolific debate. The combination of paleopathological data with historical sources, iconography, and archaeological contexts were the primary sources used to reconstruct its historical path. However, there are some limitations to paleopathological diagnosis due to the nature of bone reaction to stimuli. In addition, historical sources are subjected to a bias of social and cultural nature and the knowledge of those who wrote them. Hence, ancient DNA analysis offers the possibility of acquiring proof of cause by identifying pathogens in an organism. We undertook a metagenomic study of a skeleton exhumed from the Royal Hospital of All Saints (Portugal), renowned for treating syphilis from the 16th century onwards. The skeleton had previously been diagnosed with syphilis according to paleopathological analysis. However, the metagenomics analysis showed no presence of the pathogen associated with syphilis (i.e., Treponema pallidum) but revealed pathogenic microorganisms related to respiratory diseases (pneumonia), nonspecific bone infections (osteomyelitis), and oral bacterial pathologies as well as Hansen’s disease (also known as leprosy). The results are exciting and demand a reappraisal of the observed bone changes, recontextualizing their characterization as syphilis related. They prove that past reconstruction of health and disease diagnoses based on assessing human osteological remains of known context (such as a syphilitic hospital) may bias interpretations and, therefore, caution is recommended, not forgetting that the absence of evidence is not evidence of absence (in this case of syphilis) in life.

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