Detection of myocarditis during the first year after discovery of a dilated cardiomyopathy by endomyocardial biopsy and gallium-67 myocardial scintigraphy: prospective multicentre French study of 91 patients

Bouhour, J B; Hélias, J.; Lajartre, A. Y. De; Petitier, H; Komajda, Michel; Léger, A.; Delcourt, A; Sacrez, A; Bareiss, P; Constantinesco, A.; Bellocq, Jean‐Pierre; Ferrière, M; Chevalier, Clément; Baldet, Piérre; Cassagnes, J; Peycelon, P.; Kantelip, B; Geslin, P; Pézard, P.; Saint‐André, Jean‐Paul

doi:10.1093/oxfordjournals.eurheartj.a062538

Cited by 13 publications

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“…The inflammation-avid radioisotope, gallium-67, demonstrated avidity to the inflamed myocardium in patients with DCM and biopsy-proven myocarditis (193). In expanded clinical trials, the sensitivity and specificity of this technique did not justify clinical use (194)(195)(196)(197). Indium-111-monoclonal antimyosin antibody imaging is highly sensitive with low specificity for myocarditis (198).…”

Section: Laboratory and Noninvasive Testingmentioning

confidence: 99%

Human viral cardiomyopathy

Maisch

Ristić²,

Portig³

et al. 2003

Front Biosci

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Viral infection of the heart is relatively common, usually asymptomatic and has a spontaneous and complete resolution. It can, however, in rare cases, lead to substantial cardiac damage, development of viral cardiomyopathy and congestive heart failure. Viral cardiomyopathy is defined as viral persistence in a dilated heart. It may be accompanied by myocardial inflammation and then termed inflammatory viral cardiomyopathy (or viral myocarditis with cardiomegaly). If no inflammation is observed in the biopsy of a dilated heart (<14 lymphocytes and macrophages/mm ) the term viral cardiomyopathy or viral persistence in dilated cardiomyopathy should be applied. The diagnosis of myocarditis and viral cardiomyopathy can be made only by endomyocardial biopsy, implementing the WHO/WHF criteria, and PCR techniques for identification of viral genome. The most frequent cardiotropic viruses detected by endomyocardial biopsy are Parvo B19, enteroviruses, adenoviruses, cytomegalovirus, and less frequently Epstein-Barr virus, and influenza virus.

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Section: Laboratory and Noninvasive Testingmentioning

confidence: 99%

Human viral cardiomyopathy

Maisch

Ristić²,

Portig³

et al. 2003

Front Biosci

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“…En algunas comunicaciones estos cambios parecen ser mayores en ventriculo derecho 3 . De esta falta de sensibilidad y especificidad tambien adolecen la ecocardiografia 10 y cintigrafia con galio 11 . Actualmente se investigan nuevos procedimientos para el diagnOstico, aunque existen algunas miocarditis cuya presentation orienta a etiologias especi'ficas 12 -14 .…”

Section: Comentariounclassified

Convulsiones y paro cardiaco: forma inhabitual de presentación de miocarditis asociada a virus de Epstein Barr

Mericq¹,

T²

1993

Rev. chil. pediatr.

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Epstein Barr virus myocarditisThe incidence of cardilis in infectious mononucleosis is low. Clinical manifestations of heart involvement Include electrocardiographic changes in 6% and caidiac symptoms in 0.7% of confirmed cases. A previously healthy 9 year old boy came to the emergency room of a melropolitan children's hospilal at Sanliago, Chile, because of generalized Ionic seizures, which did nol respond to phenoborbital and neither to diazepam. He was transferred to the intensive care unit in coma, score 3 by Glasgow Scale, with irregular bradicardia and recurrent apnea. He was conecled lo mechanical ventilation. His cardiac monitoring, showed complete atrioventricular Hock with atrial rate 1 50 : min and ventricular rate 53: min. He had five episodes of asystole, requiring cardiorespiratory resuscitation, isoproterenol, dopamine and prednisone. His course was critical with hypotension, persisting AV block and, 24 hours after admission had a new period of asystole: an external pacemaker was then installed. Chest x ray showed heart enlargement. Echocardiographic findings included right atrial and ventricular dilation, wall edema and lowered left ventricular performance. Serum creatine phosphokinase activity was 196 U/l at admitance and 29 U/l six days later, while serum levels of muscle brain isoenzime were 53 U/l and 22 U/l respectively, thus suggesting myocardial injury. Serological investigations for echo and coxsackie viruses were negative. Epstein Barr virus anticapside IqM on arrival and at day ten after admission was 1/40 [highest dilution title], C-reactive protein 6 mg/l, erilhrocite sedimentation rate 10 mm/h., search for rheumatoid factor gave negative results. Isoprotsrenol was continued for three days, dopamine for nine days and external pacemaker for 1 7 days. He was dismissed at t 8 days after admission wilhoul pharmacological or electrical support, in sinus rhythm with isolated ventricular extrasystoles.(Key words t Myocarditis, Epstein Barr virus, complete heart block.)

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Pharmacologic Management of Heart Failure in the Ambulatory Setting

Givertz

Cohn

2007

Cardiovascular Therapeutics

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Detection of myocarditis during the first year after discovery of a dilated cardiomyopathy by endomyocardial biopsy and gallium-67 myocardial scintigraphy: prospective multicentre French study of 91 patients

Cited by 13 publications

References 0 publications

Human viral cardiomyopathy

Human viral cardiomyopathy

Convulsiones y paro cardiaco: forma inhabitual de presentación de miocarditis asociada a virus de Epstein Barr

Pharmacologic Management of Heart Failure in the Ambulatory Setting

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