Detection of nanogram quantitites of hexachlorophene by ultraviolet liquid chromatography

Abstract

were recorded over long periods of time. The change in potential was of the same order as the drift of the blank. The pH of the solutions used in the liquid membrane studies was taken immediately following the completion of the study because the pH changed so rapidly. Hence no comparison could be made with the solid electrode studies.The results obtained with the solid membrane electrode in phosphate and borate buffers did not differ significantly. Therefore, it was concluded that phosphate must interfere in the alkylation step rather than in the cyclization reaction. CONCLUSIONSThe ion-selective electrodes used in this study offered a rapid, continuous, and simple method for the measurement of rate constants without a flow-through system. It is suggested that other electrodes could similarly be applied in reaction mechanism studies and in the determination of rate constants.

Phenacyl esters of fatty acids via crown ether catalysts for enhanced ultraviolet detection in liquid chromatography

“…Papa and Turner (9) have detected carbonyl compounds using 2,4-dinitrophenylhydrazone derivatives down to 5-ng levels, while Carey and Persinger ( 0) have detected similar compounds down to the 40-ppm level using dinitrophenyl derivatives. Nanogram level detection of hexachlorophene has been accomplished with p-methoxybenzoate derivatives by Porcaro and Shubiak (11). Recently, fluorigenic labeling of various classes of compounds has been applied in LC (12,13) with detection limits down in the systems than previously believed.…”

Determination of hexachlorophene in cosmetics by capillary electrophoresis compared with high performance liquid chromatography

“…Several analytical methods including paper and plate chromatography [8], gas chromatography-electron capture detection (GC-ECD) [9], gas chromatography-mass spectrometry (GC-MS) [10], gas-liquid chromatography (GLC) [11], high-performance liquid chromatography (HPLC) [12][13][14], and ultra-high-performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-QTOF-MS) [15], have been used to determine HCP. For GC analysis, HCP usually requires suitable derivatization, although it can get higher sensitivity, the procedure is complicated and time consuming.…”

Magnetic Solid-Phase Extraction and Ionic Liquid Dispersive Liquid–Liquid Microextraction Coupled with High-Performance Liquid Chromatography for the Determination of Hexachlorophene in Cosmetics

“…Various analytical methods, including ultraviolet spectrophotometry (UV) [7], gas chromatographyelectron capture detection (GC-ECD) [8], and highperformance liquid chromatography (HPLC) [9] have been used for HCP analysis. Spectrophotometric methods are useful for determining HCP at low concentration levels, but these methods are limited by their low sensitivity.…”