Detection of Non‐<i>pylori Helicobacter</i> Species in “<i>Helicobacter heilmannii</i>”‐Infected Humans

Groote, Dominic De; Doorn, Leen–Jan van; Bulck, Kathleen Van den; Vandamme, Peter; Vieth, Michael; Stolte, Manfred; Debongnie, J. C.; Burette, A; Haesebrouck, Freddy; Ducatelle, Richard

doi:10.1111/j.1523-5378.2005.00347.x

Cited by 81 publications

(60 citation statements)

References 40 publications

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“…is rare, but is known to be associated with chronic active gastritis, peptic ulcers, and lowgrade mucosa-associated lymphoid tissue lymphoma in humans (Morgner et al 2000;Yoshimura et al 2002;Van den Bulck et al 2005;Alon et al 2010). In contrast to H. pylori, various Helicobacter species colonise the stomachs of domestic animals, which might be a reservoir for transmission to humans.…”

Section: Discussionmentioning

confidence: 99%

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Mirzaeian¹,

Sarchahi²,

Tabrizi³

et al. 2013

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to determine the efficacy of a triple anti-Helicobacter therapy using omeprazole, amoxicillin and clarithromycin (OAC) in dogs. A total of 15 healthy adult stray dogs with naturally acquired Helicobacter infection were evaluated using polymerase chain reaction and rapid urease test. Subsequently, they received a 21-day triple regimen. One day after the discontinuation of treatment, a second molecular analysis of gastric biopsies revealed complete eradication of Helicobacter DNA with negative quantitative urease testing in all 15 dogs. Our results confirmed the high prevalence of gastric Helicobacter-like organisms (GHLOs) in the stray dog population of Shiraz, Iran, and the effectiveness of our therapeutic regimen for the complete eradication of these microorganisms in stray dogs. In conclusion, for the complete elimination of non-pylori Helicobacter spp. from the gastric mucosa of dogs, a 21-day three-drug regimen with omeprazole, amoxicillin and clarithromycin is suggested.

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Section: Discussionmentioning

confidence: 99%

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Mirzaeian¹,

Sarchahi²,

Tabrizi³

et al. 2013

Vet. Med. - Czech

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“…A small target DNA fragment (78 bp) enabled the study of formalin-fixed paraffin-embedded material (98). A multiplex PCR based on the tRNA intergenic spacers and on the urease gene allowed a discrimination of the three species and, combined with a 16S rRNA gene PCR for "Candidatus Helicobacter suis," covers all of the H. heilmannii types (25,99).…”

Section: Molecular Methodsmentioning

confidence: 99%

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

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“…In gastric biopsy samples with histological evidence of H. heilmannii s.l., polymerase chain reaction (PCR)-based techniques showed that H. suis is the most prevalent H. heilmannii s.l. species infecting the human stomach, with prevalence ranging from 14% to 37% [26,27] . H. salomonis was present in 21%, H. felis in 15%, H. heilmannii s.s. in 8%, and H. bizzozzeronni in 4% of cases [27] .…”

Section: Epidemiology and Transmissionmentioning

confidence: 99%

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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Helicobacter heilmannii sensu lato (H. heilmannii s.l.) is a group of gastric non-Helicobacter pylori Helicobacter species that are morphologically indistinguishable from each other. H. heilmannii s.l. infect the stomach of several animals and may have zoonotic potential. Although the prevalence of these infections in humans is low, they are associated with gastric pathology, including mucosa-associated lymphoid tissue lymphoma, making them a significant health issue. Here, the taxonomy, epidemiology, microbiology, diagnosis, and treatment of these infections will be reviewed. The gastric pathology associated with H. heilmannii s.l. infections in humans will also be addressed. Finally, the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be reviewed. The understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute H. heilmannii s.l. is essential for developing strategies for prevention and treatment of these infections. Core tip: Helicobacter heilmannii sensu lato is a group of non-Helicobacter pylori Helicobacter species that infect the stomach of animals and humans. In the human stomach, these infections are associated with several pathologies, but it is currently unknown whether certain species are more often associated with a certain disease outcome than others. The access to bacterial genomes together with the availability of increasing numbers of in vitro isolates will allow significant advances in the understanding of species-specific bacteria-host interactions in disease pathogenesis and will be essential for future development of strategies to prevent and treat these infections.

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Detection of Non‐pylori Helicobacter Species in “Helicobacter heilmannii”‐Infected Humans

Abstract: This study identifies animal Helicobacter species in the stomach of a large series of HHLO-infected patients, which may have clinical implications in a subset of patients with gastric disease.

Cited by 81 publications

References 40 publications

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

Helicobacter heilmannii sensu lato: An overview of the infection in humans

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