Detection of occult tumor cells in regional lymph nodes is associated with poor survival in pN0 non-small cell lung cancer: a meta-analysis

He, Zhicheng; Xia, Yang; Tang, Shaowen; Chen, Yijiang; Chen, Liang

doi:10.21037/jtd.2016.02.52

Cited by 9 publications

(11 citation statements)

References 42 publications

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“…As the second leading cause of death after heart disease, 1 cancer includes a group of diseases characterized by irregular cell division and proliferation. Lung cancer is the most deadly type.…”

Section: Introductionmentioning

confidence: 99%

RGD-modified nanoliposomes containing quercetin for lung cancer targeted treatment

Zhou

Liu

Zhao

et al. 2018

OTT

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PurposeThe aim of this study was to prepare RGD-modified nanoliposomes containing quercetin (QCT) distearoyl-L-a-phosphatidylethanolamine-polyethylene glycol 2000-RGD-liposomes ([DSPE]-PEG2000-RGD-LPs/QCT) for lung cancer targeting treatment.MethodsThe physicochemical parameters of (DSPE)-PEG2000-RGD-LPs/QCT were characterized in terms of the particle size, zeta potential, morphology, entrapment efficiency, drug loading, and in vitro release behavior. In vivo, pharmacokinetics and antitumor studies of prepared formulations were also evaluated.ResultsIn this study, QCT was found to be easily dispersed in lipid solution and entrapped by the thin-film hydration method. The encapsulation ratio and drug loading of prepared LPs were 89.2%±7.4% and 9.2%±1.3% and the mean diameter was 93.4±7.2 nm from 3 batches. The results of in vitro experiments showed that the particle size of liposomes was suitable for the fenestrated vasculatures of cancer tissues via the enhanced permeability retention effect. In vitro, a relatively slow QCT release profile was observed in (DSPE)-PEG2000-RGD-LPs, and the release mechanism fit with the Higuchi equation better. In vivo imaging results indicated that RGD-modified LPs had very good tumor targeting ability. (DSPE)-PEG2000-RGD-LPs/QCT showed a significant antitumor activity in mice with A549 tumors.ConclusionThrough this study, it was found that the RGD-modified LPs loaded with QCT could potentially be a very promising lung-targeted preparation.

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Section: Introductionmentioning

confidence: 99%

RGD-modified nanoliposomes containing quercetin for lung cancer targeted treatment

Zhou

Liu

Zhao

et al. 2018

OTT

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“…Cancer is the second leading cause of mortality after heart disease (1). Cancer comprises a group of diseases characterized by the unregulated division and proliferation of cells.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural changes during lung carcinogenesis-modulation by curcumin and quercetin

Wang

Zhang

et al. 2016

Oncology Letters

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The aim of the present study was to examine the effectiveness of curcumin and quercetin in modulating ultrastructural changes during lung carcinogenesis. A total of 24 male laka mice were divided into the normal control, benzo[a]pyrene (BP)-treated, BP+curcumin-treated, BP+quercetin- treated, and BP+curcumin+quercetin-treated groups (n=6 per group). Lung carcinogenesis was induced by a single intraperitoneal injection of BP [100 mg/kg of body weight (b.wt.)]. Curcumin was supplemented to mice at a dose level of 60 mg/kg of b.wt. in drinking water and quercetin was given at a dose level of 40 mg/kg of b.wt. in drinking water. The ultrastructure of BP-treated mice revealed disruptions in cellular integrity together with nuclear deformation and premature mitochondrial aging. Notably, supplementation with phytochemicals individually resulted in improvement of the ultra-histoarchitecture of BP-treated mice although the improvement was much greater with combined supplementation of phytochemicals. Furthermore, BP treatment revealed alterations in lung histoarchitecture, which, however, were improved appreciably following combined supplementation with curcumin and quercetin. The results of the present study show that, combined supplementation with curcumin and quercetin effectively preserved the histoarchitecture as well as ultra-histoarchitecture during BP-induced lung carcinogenesis in mice.

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“…2-4 Prognosis is strongly linked to the detection of metastatic disease in local and regional nodes, and survival is reduced by even the presence of occult micrometastatic disease. 5,6…”

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confidence: 99%

Long-term outcomes after near-infrared sentinel lymph node mapping in non–small cell lung cancer

Digesu

Hachey

Gilmore

et al. 2018

The Journal of Thoracic and Cardiovascular Surgery

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Detection of occult tumor cells in regional lymph nodes is associated with poor survival in pN0 non-small cell lung cancer: a meta-analysis

Abstract: The prognosis of patients with OTCs is inferior to those without OTCs in the terms of OS and DFS regardless of detection methods, study types and MLND.

Cited by 9 publications

References 42 publications

RGD-modified nanoliposomes containing quercetin for lung cancer targeted treatment

RGD-modified nanoliposomes containing quercetin for lung cancer targeted treatment

Ultrastructural changes during lung carcinogenesis-modulation by curcumin and quercetin

Long-term outcomes after near-infrared sentinel lymph node mapping in non–small cell lung cancer

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