Detection of organotin, organomercury, and organolead compounds with a pulsed discharge detector (PDD)

Forsyth, Don; Taylor, Jennifer E.

doi:10.1007/s00216-002-1479-4

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…For simple gases such as hydrogen, the LDR can be up to five orders of magnitude (Grombik et al 2006, Novelli et al 2009. However, for complex organic molecules such as those reported here, LDR of two-three orders of magnitude is more common (Hunter et al 1999, Forsyth andTaylor 2002). Our LDR data are also not dissimilar to those reported for methyl p-anisate using honeybees where the sensitivity appeared to plateau beyond this range (Suckling and Sagar 2011).…”

Section: Sensitivity and Linear Dynamic Rangesupporting

confidence: 55%

Diagnostic potential of the pulsed discharged helium ionization detector (PDHID) for pathogenic Mycobacterial volatile biomarkers

et al. 2013

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Pathogenic Mycobacteria cause diseases in animals and humans with significant economic and societal consequences. Current methods for Mycobacterial detection relies upon time- and labor-intensive techniques such as culturing or DNA analysis. Using gas chromatography and mass spectrometry, four volatile compounds (methyl phenylacetate, methyl p-anisate, methyl nicotinate and o-phenyl anisole) were recently proposed as potential biomarkers for Mycobacteria. We demonstrate for the first time the capabilities of a field-deployable, pulsed discharge helium ionization detector (PDHID) for sensing these volatiles. We determined the analytical performance of the PDHID toward these Mycobacterial volatiles. Detector performance was moderately affected over the temperature range of 150 to 350 °C. The linear dynamic range for all four analytes exceeded three orders of magnitude. The limits of detection (LOD) and quantitation (LOQ) were calculated as 150 and 450 pg respectively, for all compounds, except methyl phenylacetate (LOD and LOQ, 90 and 270 pg, respectively). Control charts revealed that the PDHID detection system was generally stable, and deviations could be traced to common causes and excluded special causes. Grob tests and ionization potential data suggest that the PDHID is capable of detecting Mycobacterial volatiles in a complex milieu such as culture headspace or breath samples from tuberculosis patients. The diagnostic potential of the PDHID is critical to our goal of a handheld, field-deployable 'sniffer' system for biological pathogens and chemical warfare agents.

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Section: Sensitivity and Linear Dynamic Rangesupporting

confidence: 55%

Diagnostic potential of the pulsed discharged helium ionization detector (PDHID) for pathogenic Mycobacterial volatile biomarkers

et al. 2013

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“…Our laboratory has tested the response of organotin, organomercury and organolead compounds by He-PDPID and PDECD [33]. The reported limits of detection (S/N = 3) ranged from 0.4 to 1.2 pg in the He-PDPID mode.…”

Section: Organometallicsmentioning

confidence: 98%

Pulsed discharge detector: theory and applications

Forsyth¹

2004

Journal of Chromatography A

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The pulsed discharge detector (PDD) is a significant advancement in gas chromatography (GC) detector design which can be operated in three different modes: pulsed discharge helium ionization (He-PDPID), pulsed discharge electron capture (PDECD) and helium ionization emission (PDED). The He-PDPID can detect permanent gases, volatile inorganics and other compounds which give little or no response with the flame ionization detector (FID) and has significantly better limits of detection (minimum detectable quantities (MDQs) in low picogram range) than can be achieved with a thermal conductivity detector (typically not lower than 1 ng). The PDECD has similar or better sensitivity (MDQs of 10(-15) to 10(-12) g) than radioactive source ECD but does not require licensing, wipe tests and other administrative or safety requirements which have increased over security concerns. The PDED shows promise as an extremely selective and sensitive elemental detector but a commercial unit is not presently available. In this report, the theory of operation, applications of the PDD and the practical aspects of using this novel detector are presented.

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Elemental Trace Analysis in Studies of Food Products

Grembecka

Szefer

2016

Handbook of Trace Analysis

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Detection of organotin, organomercury, and organolead compounds with a pulsed discharge detector (PDD)

Cited by 6 publications

References 9 publications

Diagnostic potential of the pulsed discharged helium ionization detector (PDHID) for pathogenic Mycobacterial volatile biomarkers

Diagnostic potential of the pulsed discharged helium ionization detector (PDHID) for pathogenic Mycobacterial volatile biomarkers

Pulsed discharge detector: theory and applications

Elemental Trace Analysis in Studies of Food Products

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