Detection of polyomavirus SV40 in tonsils from immunocompetent children

Patel, Niraj; Vilchez, Regis A.; Killen, Deanna E.; Zanwar, Preeti; Šroller, Vojtěch; Eldin, Karen W.; López‐Terrada, Dolores; Butel, Janet S.

doi:10.1016/j.jcv.2008.04.011

Cited by 37 publications

(32 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, it has been suggested that under peculiar host conditions, BKV could participate in the oncogenic process [23,24]. It has been reported that BKV DNA viral load was higher in transformed cells than in nonneoplastic cells [19,25]. However, additional experiments are needed to prove our hypotheses.…”

Section: Discussionmentioning

confidence: 79%

The significance of mannose-binding lectin gene polymorphisms on the risk of BK virus coinfection in women with human papillomavirus–positive cervical lesions

et al. 2011

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 79%

The significance of mannose-binding lectin gene polymorphisms on the risk of BK virus coinfection in women with human papillomavirus–positive cervical lesions

et al. 2011

View full text Add to dashboard Cite

“…that different routes of transmission are responsible for SV40 infection (37)(38)(39)(40)(41)(42)(43)(44)(45).…”

Section: Discussionmentioning

confidence: 99%

High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma

Mazzoni¹,

Corallini

Cristaudo

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Human malignant pleural mesothelioma (MPM) is considered a rare tumor, but recent estimations indicate that one-quarter million people will die of this neoplasm in Europe in the next three decades. The mineral asbestos is considered the main causative agent of this neoplasm. MPM is largely unresponsive to conventional chemotherapy/radiotherapy. In addition to asbestos exposure, genetic predisposition to asbestos carcinogenesis and to simian virus (SV) 40 infection has also been suggested. SV40 is a DNA tumor virus found in some studies to be associated at high prevalence with MPM. SV40 sequences have also been detected, although at a lower prevalence than in MPM, in blood specimens from healthy donors. However, some studies have failed to reveal SV40 footprints in MPM and its association with this neoplasm. These conflicting results indicate the need for further investigations with new approaches. We report on the presence of antibodies in serum samples from patients affected by MPM that specifically react with two different SV40 mimotopes. The two SV40 peptides used in indirect ELISAs correspond to viral capsid proteins. ELISA with the two SV40 mimotopes gave overlapping results. Our data indicate that in serum samples from MPM-affected patients (n = 97), the prevalence of antibodies against SV40 viral capsid protein antigens is significantly higher (26%, P = 0.043) than in the control group (15%) represented by healthy subjects (n = 168) with the same median age (66 y) and sex. Our results suggest that SV40 is associated with a subset of MPM and circulates in humans.antibody | neoplasia

show abstract

“…For example, SV40 has recently been detected in tissues and excreta of healthy humans, including blood, tonsils, urine, and stool, as well as in diseased kidneys and certain malignancies (6,7,9,19,27,39,40). The prevalence of infection in different populations is not known but appears to be low (9,33).…”

Section: Discussionmentioning

confidence: 99%

Polyomavirus Shedding in the Stool of Healthy Adults

Vanchiere

Abudayyeh²,

Copeland

et al. 2009

J Clin Microbiol

Self Cite

View full text Add to dashboard Cite

We recently reported the frequent detection of polyomaviruses (BK virus [BKV] or simian virus 40 [SV40])in 46% of stool samples from hospitalized children. In order to determine if adults exhibit fecal shedding of polyomavirus, single stool specimens from healthy adults were evaluated by PCR. Overall, 20 (18.2%) of 110 specimens were positive for human polyomaviruses: 9 with BKV, 9 with JC virus (JCV), 1 with SV40, and 1 with both JCV and SV40. Among the 94 subjects without immune compromise, 17 (18.1%) were excreting polyomaviruses. This shedding frequency in adults was significantly lower than that observed in children (P < 0.001). These findings support the hypothesis that the gastrointestinal tract may be a site of polyomavirus persistence, and they suggest a fecal-oral route of viral transmission.Seroprevalence studies from various parts of the world have documented the ubiquity of early childhood infection with BK virus (BKV), a polyomavirus whose host-range is limited to humans (15,35). Infection with BKV has not been associated with any known clinical syndrome in healthy individuals, and BKV persistence is believed to be lifelong, primarily in the kidney and in leukocytes (32). BKV is occasionally excreted in the urine of healthy adults and children (20). BKV viruria may be common among pregnant women, perhaps reflecting the mild immune compromise of pregnancy (2, 10). Among kidney transplant recipients, BKV reactivation can lead to high titers of virus in the urine and the development of polyomavirusassociated nephropathy, which has emerged as a significant cause of renal allograft loss (13,17,18). After hematopoietic stem cell transplantation, BKV reactivation can cause hemorrhagic cystitis, a painful syndrome that usually resolves following engraftment of T-cell lineages (24,25).JC virus (JCV) infection occurs somewhat later in life, more commonly in the second and third decades (22). As with BKV, there is no recognized clinical syndrome associated with primary JCV infection, and it has emerged as an important cause of disease among severely immunocompromised patients (4,31,41). JCV reactivation in patients with AIDS and other T-lymphocyte deficiencies can result in progressive multifocal leukoencephalopathy, which is uniformly fatal in the absence of restored T-lymphocyte function. JCV has been detected in both colon and gastric cancers and adjacent normal tissues, suggesting that the gastrointestinal tract is a site of JCV persistence, but it has not previously been detected in feces (23,30,34,39). SV40 has been detected in urine and feces from humans and in mixed fecal and urine specimens from cynomolgus monkeys (3,39,40).Despite the ubiquity of BKV infection, its route of transmission has not been clearly determined. In addition to urinary excretion, BKV has been detected rarely in respiratory secretions and tonsil tissue (16, 37). It has also been detected in placental tissue, but whether it is transmitted in utero has not been determined (5, 28). Recent studies by our laboratory have detected po...

show abstract

Detection of polyomavirus SV40 in tonsils from immunocompetent children

Cited by 37 publications

References 38 publications

The significance of mannose-binding lectin gene polymorphisms on the risk of BK virus coinfection in women with human papillomavirus–positive cervical lesions

The significance of mannose-binding lectin gene polymorphisms on the risk of BK virus coinfection in women with human papillomavirus–positive cervical lesions

High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma

Polyomavirus Shedding in the Stool of Healthy Adults

Contact Info

Product

Resources

About