Detection of Pro-Inflammatory IL-8 and IL-12 in Iraqi Women Infected with Trichomoniasis

Ali, Hayder Z.

doi:10.24996/ijs.2021.62.2.10

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…These results also agree with other investigators, including Shaio et al [58] who reported an approximately 55% reduction in the half-life of IL-8 mRNA in monocytes culture treated with membrane T. vaginalis components. However, our results disagree with some other studies, such as that of Kucknoor et al [59] and Ali [60]; they found a higher level of IL-8 in both acute and chronic T. vaginalis infections. T. vaginalis releases extracellular exosome-like vesicles and other factors that play important roles in immunomodulation of some interleukins in response to infection [5].…”

Section: 3 Il-1 and Il-8contrasting

confidence: 99%

Some Clinical and Inflammatory Aspects of Trichomonas vaginalis Infection among Women with Pelvic Inflammatory Diseases

Jabbar

Al-Warid

2021

eijs

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Infection with Trichomonas vaginalis and its relation to some diseases have lately had much attention. The objective of this study was to assess the infection rate of T. vaginalis and its relation to pelvic inflammatory diseases, infertility, and vaginosis. The study also assessed some demographic, clinical, and immunological parameters in women infected with T. vaginalis. The study included 160 non-pregnant married women who attended some private clinics and public hospitals in Baghdad from October 2020 to February 2021. All participants had symptoms of vaginal discharge only or vaginal discharge with lower abdominal pain. The participants were divided into an infertility group (n = 61) and fertility group (n = 99). The participants were also divided into Pelvic Inflammatory Disease (PID) group (n=41) and non-PID group (n=119). All participants underwent vaginal examination. Vaginal swabs were taken from all participants for T. vaginalis, bacteria, yeast, clue cell, pH, and vaginal leukocyte examinations. Sera were also taken to measure both IL-1α and IL-8 using sandwich ELISA technique to compare them with apparently healthy control subjects who had no vaginal discharge. The study revealed that the total infection rate of T. vaginalis was 14.37%. The results showed no significant relations between T. vaginalis positive status and each of age, infertility, vaginosis, contraceptive use, and high BMI. While a significant relation (P=0.03) was noticed between T. vaginalis positive status and PID. Women with PID exhibited a higher infection rate with T. vaginalis (24.39%) versus non PID women (10.92%). High clue cells number was not significantly related to T. vaginalis positive status, only if both PID and vaginosis were considered in the statistical analysis. In addition, high leukocytes count was not related to T. vaginalis positive status. While abnormal vaginal pH was significantly (P=0.01) related to T. vaginalis positive status. Finally, the levels of both IL-1α and IL-8 were noticed to be declined in women who had T. vaginalis infection, although they were not declined significantly. This study gives an insight about some clinical aspects of T. vaginalis infection among PID women. T. vaginalis is highly predictable in women with PID. Consequently, attention and more investigation would be needed on this topic in Iraq.

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Section: 3 Il-1 and Il-8contrasting

confidence: 99%

Some Clinical and Inflammatory Aspects of Trichomonas vaginalis Infection among Women with Pelvic Inflammatory Diseases

Jabbar

Al-Warid

2021

eijs

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“…The results demonstrate that the infection rates in women are higher than in men, which were 31.7% and 24.2%, respectively (73). Another recent research was done in Baghdad city targeting pro-inflammatory cytokines in the serum of infected women with T. vaginalis, showing that this parasite's IL-8 and IL-12 may alter during infection (74). In Al-Diwaniya city, direct wet mount microscopy and culture were used to detect this parasite in vaginal swabs collected from female pregnant patients.…”

Section: T Vaginalis In Humansmentioning

confidence: 99%

A review on Trichomonas species infection in humans and animals in Iraq

Al-Hasnawy¹,

Rabee²

2023

IJVS

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Trichomonas is a common protozoan that causes a sexually transmitted disease in humans called Trichomonosis and venereal and intestinal Trichomonosis in cattle and cats, respectively. This parasite also causes avian Trichomonosis, or canker, in birds' gastrointestinal tract. Three main pathogenic species (T. vaginalis, T. fetus, and T. gallina) belonging to this genus are identified and recorded in different parts of the world. However, their presence and epidemiology are still incompletely known in other parts, particularly in T. fetus in Iraq. This review aims to update information on this disease based on an electronic search of databases to document the presence and prevalence of Trichomonas spp. in humans and some animals in Iraqi cities. The findings show that the infection by T. vaginalis and T. tenax in humans and T. gallinae in birds are identified in Iraq, recording different percentage rates. However, venereal and intestinal Trichomonosis caused by T. fetus tends to be slight or absent in cattle and cats. Venereal Trichomonosis is only found in Basra and Nineveh provinces cattle, while intestinal Trichomonosis is not recorded in Iraq yet. T. hominis is recorded in central and northern areas of Iraq. In conclusion, less or absence of the infection in cattle or cats may be ascribed to animal breed, climate, less of studies, and/or other unknown factors. Thus, epidemiological and molecular studies are needed to investigate the presence and prevalence of this disease, particularly in cattle and cats of Iraq.

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“…Research in New Zealand demonstrated that during a 17month period from March 1985 to July 1986, 30 patients and four staff members were infected with S. aureus or colonized with one strain of MRSA during disease onset at Wellington Hospital. Initially, disinfection occurred through the ICU but Infected or colonized patients were distributed to 14 hospital wards and to five other hospitals in New Zealand, where septicemia contributed to the death of two patients (22,34).…”

Section: Countries Of the Worldmentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus and New Delhi Metallo beta-lactamases- types of antibiotic resistance, methods of prevention.

Al-Hussaniy

Al-tameemi

2022

Med Pharm J.

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Methicillin was known as an antibiotic that was used to treat many infections caused by Staphylococcus aureus, but in a short period of time this antibiotic entered the medical field and eventually led to the emergence of methicillin-resistant strains of bacteria, and it is believed that methicillin resistance resulted from the bacterial acquisition of a gene that encodes a protein capable of. This strain is known as methicillin-resistant aureus, MRSA. However, the danger of antibiotic resistance does not stop there, especially if we know the emergence of new strains of bacteria that are resistant to the most powerful antibiotics, namely New Delhi Metallo beta-lactamases. In this article, we will talk about the two types of antibiotic resistance, methods of prevention and reduction of resistance, and a brief history of each of them.

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Detection of Pro-Inflammatory IL-8 and IL-12 in Iraqi Women Infected with Trichomoniasis

Cited by 4 publications

References 23 publications

Some Clinical and Inflammatory Aspects of Trichomonas vaginalis Infection among Women with Pelvic Inflammatory Diseases

Some Clinical and Inflammatory Aspects of Trichomonas vaginalis Infection among Women with Pelvic Inflammatory Diseases

A review on Trichomonas species infection in humans and animals in Iraq

Methicillin-Resistant Staphylococcus aureus and New Delhi Metallo beta-lactamases- types of antibiotic resistance, methods of prevention.

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