Detection of prostate cancer by sialic acid level in patients with non-diagnostic levels of prostate-specific antigen

Michalakis, Konstantinos; Ilias, Ιoannis; Triantafyllou, Aggeliki; Polymeris, Antonis; Kastriotis, Ioannis; Chairakaki, Aikaterini-Dimitra; Savopoulos, Christos

doi:10.1016/j.maturitas.2012.07.016

Cited by 18 publications

(19 citation statements)

References 15 publications

(25 reference statements)

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“…Thus, serum sialic acid (SA) concentration will increase in those tumors over-expressing glycoproteins and glycolipids and can be used as a diagnostic marker of cancer [13,14]. Studies found that serum SA was elevated in patients with colorectal tumor, prostate cancer and ovarian malignancies and approved it could be used as a marker for tumor diagnosis in clinical practice [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Combined detection of sialic acid and hydroxyproline in diagnosis of ovarian cancer and its comparison with human epididymis protein 4 and carbohydrate antigen 125

Zhang

Li³

et al. 2015

Clinica Chimica Acta

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Section: Introductionmentioning

confidence: 99%

Combined detection of sialic acid and hydroxyproline in diagnosis of ovarian cancer and its comparison with human epididymis protein 4 and carbohydrate antigen 125

Zhang

Li³

et al. 2015

Clinica Chimica Acta

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“…One of the most prominent alterations is sialylation including change in linkage of sialic acid from α‐(2,6) linkage to α‐(2,3) linkage during PCa progression. SNA binds preferentially to sialic acid attached to terminal galactose in α‐(2,6) linked sialic acid which is commonly presented in healthy man . Jolly et al.…”

Section: Resultsmentioning

confidence: 99%

“…One of the most prominent alterations is sialylation including change in linkage of sialic acid from ␣-(2,6) linkage to ␣-(2,3) linkage during PCa progression. SNA binds preferentially to sialic acid attached to terminal galactose in ␣-(2,6) linked sialic acid which is commonly presented in healthy man [29][30][31][32]. Jolly et al and Pihikova et al demonstrated that PSA from healthy individuals has high content of ␣-(2,6) sialic acid assessed by strong interaction of PSA with SNA, lectin preferentially binding to ␣-(2,6) linked sialic acid.…”

Section: Study Of Lectin-psa Interactions By Sprmentioning

confidence: 99%

Determining the binding affinities of prostate‐specific antigen to lectins: SPR and microarray approaches

2016

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Prostate cancer (PCa) is one of the most common newly diagnosed cancers among men and we focused on its traditional biomarker, prostate-specific antigen (PSA), using targeted glycomics-based strategies. The aberrant glycosylation pattern of PSA may serve as a valuable tool for improving PCa diagnosis including its early-stage. In this study, we evaluated the usability of two techniques, surface plasmon resonance and protein microarray assay, for the study and characterization of interactions of PSA (both free and complexed) with six lectins (SNA, ConA, RCA, AAL, WGA and MAA II). The information on the character of such interactions is important for the application of lectins as prospective bioreceptors for biomarker glycoprofiling in a follow-up biosensing assays. SPR as well as established bioanalytical techniques allowed determination of K values of PSA-lectin interactions in a more reliable way than protein microarray. The protein microarray method did not allow accurate quantification of K values. However, the features of a microarray approach, such as speed and costs, enabled the screening and estimation of the nature of lectin-glycan biomarker interaction in an effective and time-saving way. All of the tested lectins interacted with commercial PSA standard isolated from healthy persons, except MAA II which reacted only very weakly.

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“…A number of studies demonstrated the feasibility of determining sialic acids for the diagnosis of colorectal cancer [7], thyroid cancer [8], prostate cancer [9], ovary cancer [10], and oral cavity cancer [11]. However, the diagnostic value of sialic acids as a marker of LC was never explored.…”

Section: Introductionmentioning

confidence: 99%

Sialic Acids of Saliva in Primary and Differential Diagnosis of Lung Cancer

Bel’skaya¹,

Kosenok²,

Массард³

2018

Sovrem Tehnol Med

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The aim of the study was to explore the option of using sialic acid of saliva as a marker for primary and differential diagnosis of lung cancer.Materials and Methods. The study included 1903 subjects divided as follows: the main group (lung cancer, n=337, and nonmalignant lung diseases, n=108), the comparison group (other types of oncological diseases, n=1033), and the control group (generally healthy, n=425). All participants filled the medical questionnaires and presented the histological verification of their diagnoses; then they underwent biochemical examination of their saliva samples. The level of sialic acids and the content of mucin in the saliva were determined spectrophotometrically.Results. We found that the average level of sialic acids in the control group (0.270±0.037 mmol/L) was significantly higher than that in lung cancer (0.138±0.006 mmol/L) or non-tumor diseases of the lungs (0.148±0.003 mmol/L). The saliva content of sialic acids did not significantly differ between various histological types of lung cancer (0.175±0.027 and 0.166±0.024 mmol/L for squamous cell lung cancer and adenocarcinoma, respectively). We also noted that in patients with metastatic lung cancer, the level of sialic acids in the saliva was the lowest as compared with the generally healthy subjects.Conclusion. The level of sialic acids in the saliva decreases both in patients with lung cancer and in patients with non-malignant lung diseases. These results rationalize the option of using this parameter for the primary diagnosis of lung disorders as a whole; however, for the differential diagnosis of various lung diseases, the level of saliva sialic acids is of little value.

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Detection of prostate cancer by sialic acid level in patients with non-diagnostic levels of prostate-specific antigen

Cited by 18 publications

References 15 publications

Combined detection of sialic acid and hydroxyproline in diagnosis of ovarian cancer and its comparison with human epididymis protein 4 and carbohydrate antigen 125

Combined detection of sialic acid and hydroxyproline in diagnosis of ovarian cancer and its comparison with human epididymis protein 4 and carbohydrate antigen 125

Determining the binding affinities of prostate‐specific antigen to lectins: SPR and microarray approaches

Sialic Acids of Saliva in Primary and Differential Diagnosis of Lung Cancer

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