Detection of Regional Left Ventricular Dysfunction in Early Pacing-Induced Heart Failure Using Ultrasonic Integrated Backscatter

Nozaki, Shiro; An, Dong‐Aolei; Ga, Helmer; Hk, Hammond

doi:10.1161/01.cir.92.9.2676

Cited by 25 publications

(19 citation statements)

References 45 publications

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“…The mechanisms that contribute to CVIBS include sarcomere length, change in fiber orientation during the cardiac cycle, and the deposition of cross- linked myocardial collagen (18−23). Several previous studies have demonstrated that CVIBS reflects the intrinsic contractile function of the heart (18,24,25), although other groups have been unable to relate systolic thickening to the amplitude of CVIBS (26,27). Factors associated with CVIBS may be different for each pathologic condition.…”

Section: Discussionmentioning

confidence: 96%

Impact of the Angiotensin II Receptor Antagonist, Losartan, on Myocardial Fibrosis in Patients with End-Stage Renal Disease: Assessment by Ultrasonic Integrated Backscatter and Biochemical Markers

et al. 2005

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Section: Discussionmentioning

confidence: 96%

Impact of the Angiotensin II Receptor Antagonist, Losartan, on Myocardial Fibrosis in Patients with End-Stage Renal Disease: Assessment by Ultrasonic Integrated Backscatter and Biochemical Markers

et al. 2005

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“…IBS analysis may reveal some physiological and pathological morpho-functional changes of the myocardium [12,13]. The extracellular matrix has been shown to represent an important source of myocardial IBS.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies using endomyocardial biopsy have demonstrated that IBS correlates with collagen content within the myocardium in patients with dilated cardiomyopathy and severe aortic stenosis [14,15,16]. Thus, this non-invasive technique can be used to provide a relative estimate of myocardial fibrosis in humans [12,13]. IBS has been used to study myocardial changes in patients with hypertension [17], chronic renal failure [18] and pheochromocytoma [19].…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic Characterization (Integrated Backscatter) of Myocardial Tissue in Patients with Autosomal Dominant Polycystic Kidney Disease

et al. 2010

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Objective: To study changes in myocardial wall texture in autosomal dominant polycystic kidney disease (ADPKD) patients by ultrasonic integrated backscatter (IBS) analysis. Methods: Hypertensive and normotensive ADPKD patients, essential hypertension (EHP) patients and healthy volunteers were included in the study. All the subjects underwent conventional echocardiography and ultrasonic IBS of the myocardial wall. Both the calibrated IBS (C-IBS) and the systolic-diastolic cyclical variations in IBS (CV-IBS) were evaluated. Results: Mean C-IBS in hypertensive ADPKD patients was significantly higher than that in EHP patients and normotensive ADPKD patients. Mean C-IBS in normotensive ADPKD patients was significantly higher than that in healthy subjects. Mean CV-IBS in hypertensive ADPKD patients was significantly lower than that in EHP patients and normotensive ADPKD patients. Mean CV-IBS in normotensive ADPKD patients was significantly lower than that in healthy subjects. Multivariate analysis showed that the mean C-IBS was positively related to the systolic and diastolic blood pressure (SBP, DBP) and left ventricular mass index (LVMI); mean CV-IBS was positively correlated with contractile performance and transmitral E/A ratio and inversely correlated with SBP, DBP and LVMI. Conclusions: ADPKD patients experienced myocardial interstitial collagen deposition and impairment to myocardial contractile performance, which were both aggravated by hypertension. IBS seems to be a useful tool for the assessment of myocardial changes in ADPKD patients.

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“…Using the machine that can display high-resolution IBS images, we can successfully measure IBS variables in the inner or outer layers of the regional myocardium [16][17][18]. The purpose of this study is to investigate whether we can differentiate ICM from DCM based on inter-segmental and transmural differences in the ultrasonic tissue characters.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive Differentiation of Ischemic Cardiomyopathy From Idiopathic Dilated Cardiomyopathy With Ultrasonic Tissue Characterization Using Integrated Backscatter

et al. 2005

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Background. The aim of this study was to discriminate ischemic cardiomyopathy (ICM) from dilated cardiomyopathy (DCM) based on inter-segmental and transmural differences in ultrasonic tissue characters.Methods. The study population consisted of 40 patients with DCM and 40 patients with ICM with ejection fraction of <40%. We recorded short-axis integrated backscatter (IBS) images in each patient. We measured the absolute differences in average IBS values between the anterior septum and posterior wall (|A-P|, dB). We also measured the difference of average IBS in the inner layer minus that in the outer layer in either anterior septum or posterior wall that was more dysfunctional (In-Out, dB).Results. |A-P| was significantly higher in ICM than DCM (5.3 ± 1.7 vs. 2.7 ± 1.4, p<0.001). Receiver-operating characteristic analysis demonstrated that we can differentiate ICM from DCM with sensitivity of 80 % and specificity of 73 % using |A-P| > 4 dB as a cut-off point. (In-Out) was also significantly higher in ICM than DCM (1.6 ± 1.4 vs. -0.9 ± 1.9, p<0.001). We can also differentiate ICM from DCM with sensitivity of 93 % and specificity of 70 % using (In-Out) >0 dB as a cut-off point. Additionally, all patients with |A-P| > 3 dB and (In-Out) >0 dB belonged to the ICM group except for one patient.Conclusions. Inter-segmental and transmural differences in myocardial IBS are significantly greater in the ICM than in DCM. Using these particular ultrasonic tissue characters, we can discriminate ICM from DCM with favorable sensitivity and specificity. (J Echocardiogr 2005; 3: 33-39)

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Detection of Regional Left Ventricular Dysfunction in Early Pacing-Induced Heart Failure Using Ultrasonic Integrated Backscatter

Abstract: Rapid left ventricular pacing produces abnormalities of regional myocardial function within 48 hours of pacing. Regional myocardial dysfunction is accompanied by a reduction in CVIBS in the same region.

Cited by 25 publications

References 45 publications

Impact of the Angiotensin II Receptor Antagonist, Losartan, on Myocardial Fibrosis in Patients with End-Stage Renal Disease: Assessment by Ultrasonic Integrated Backscatter and Biochemical Markers

Impact of the Angiotensin II Receptor Antagonist, Losartan, on Myocardial Fibrosis in Patients with End-Stage Renal Disease: Assessment by Ultrasonic Integrated Backscatter and Biochemical Markers

Ultrasonic Characterization (Integrated Backscatter) of Myocardial Tissue in Patients with Autosomal Dominant Polycystic Kidney Disease

Noninvasive Differentiation of Ischemic Cardiomyopathy From Idiopathic Dilated Cardiomyopathy With Ultrasonic Tissue Characterization Using Integrated Backscatter

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