Detection of rhinovirus in sinus brushings of patients with acute community-acquired sinusitis by reverse transcription-PCR

Pitkäranta, Anne; Arruda, Eurico; Malmberg, Henrik; Hayden, Frederick G.

doi:10.1128/jcm.35.7.1791-1793.1997

Cited by 159 publications

(92 citation statements)

References 17 publications

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“…However, evidence of direct viral infection of the maxillary sinus in children is lacking. In adults with acute maxillary sinusitis, a virus can be found in 10% of maxillary secretion samples by viral culture [46] and in 40% by PCR [47].…”

Section: Common Coldsmentioning

confidence: 99%

Viral upper respiratory tract infections in young children with emphasis on acute otitis media

Nokso-Koivisto

Hovi

Pitkäranta

2006

International Journal of Pediatric Otorhinolaryngology

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Viral upper respiratory infection is the most common reason for seeking medical care for children. Recurrent viral respiratory infections and subsequent complications (e.g. acute otitis media (AOM)) are a burden for children, their families and society. Over the past decade, our knowledge on the significance of respiratory viruses has broadened remarkably. Viruses cause large variety of respiratory diseases and cause alone diseases, which previously have been assumed to be bacterial only (e.g. AOM and pneumonia). Methods for detection analysis of respiratory viruses are developing making both the diagnosis and epidemiological investigations of respiratory infections easier. Accurate diagnosis of respiratory infections and awareness of possible viral etiology could reduce the use of antibiotics. Etiologic studies of viral infections are becoming increasingly important, with the emergence of new antiviral drugs and vaccines.

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Section: Common Coldsmentioning

confidence: 99%

Viral upper respiratory tract infections in young children with emphasis on acute otitis media

Nokso-Koivisto

Hovi

Pitkäranta

2006

International Journal of Pediatric Otorhinolaryngology

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“…In addition to causing cold symptoms, rhinoviruses have been implicated in the develop-ment of acute sinusitis and in the precipitation of exacerbations of chronic bronchitis and asthma. The virus has been recovered from aspirates obtained by direct puncture of the maxillary sinuses of patients with acute sinusitis (Pitkaranta et al, 1997), and mucosal thickening and/or sinus exudates have been observed in as many as 77% of subjects with acute colds (Turner et al, 1992;Gwaltney et al, 1994). Clinically manifest acute sinusitis is seen in a small (0.5 -5%) proportion of individuals with naturally occurring colds (Wald et al, 1991).…”

Section: Disease Impactmentioning

confidence: 99%

Respiratory viral infections in the elderly

Treanor

Falsey

1999

Antiviral Research

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Viral respiratory infections represent a significant challenge for those interested in improving the health of the elderly. Influenza continues to result in a large burden of excess morbidity and mortality. Two effective measures, inactivated influenza vaccine, and the antiviral drugs rimantadine and amantadine, are currently available for control of this disease. Inactivated vaccine should be given yearly to all of those over the age of 65, as well as younger individuals with high-risk medical conditions and individuals delivering care to such persons. Live, intranasally administered attenuated influenza vaccines are also in development, and may be useful in combination with inactivated vaccine in the elderly. The antiviral drugs amantadine and rimantadine are effective in the treatment and prevention of influenza A, although rimantadine is associated with fewer side-effects. Recently, the inhaled neuraminidase inhibitor zanamivir, which is active against both influenza A and B viruses, was licensed for use in uncomplicated influenza. The role of this drug in treatment and prevention of influenza in the elderly remains to be determined. Additional neuraminidase inhibitors are also being developed. In addition, to influenza, respiratory infections with respiratory syncytial virus, parainfluenza virus, rhinovirus, and coronavirus have been identified as potential problems in the elderly. With increasing attention, it is probable that the impact of these infections in this age group will be more extensively documented. Understanding of the immunology and pathogenesis of these infections in elderly adults is in its infancy, and considerable additional work will need to be performed towards development of effective control measures.

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“…Radiographic evidences of sinusitis is frequent during natural or experimental common colds, and in reality the common cold is a viral rhino-sinusitis . Using RT-PCR, viruses, most often rhinoviruses, have been found in up to 40% of sinus samples of adult patients with acute sinusitis (Pitkäranta et al, 1997). Taken together, these studies indicate that human rhinovirus infections are associated with approximately one-half of acute sinusitis in adults and over one-third of otitis media in children.…”

Section: Upper Respiratory Tract Complicationsmentioning

confidence: 85%

First International Symposium on Influenza and Other Respiratory Viruses: summary and overview

Kaiser

Couch

Galasso³

et al. 1999

Antiviral Research

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Detection of rhinovirus in sinus brushings of patients with acute community-acquired sinusitis by reverse transcription-PCR

Cited by 159 publications

References 17 publications

Viral upper respiratory tract infections in young children with emphasis on acute otitis media

Viral upper respiratory tract infections in young children with emphasis on acute otitis media

Respiratory viral infections in the elderly

First International Symposium on Influenza and Other Respiratory Viruses: summary and overview

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