Detection of Robinsoniella peoriensis in multiple bone samples of a trauma patient

Schröttner, Percy; Hartwich, Kathleen; Bunk, Boyke; Schober, Isabel; Helbig, Sina; Rudolph, Wolfram W.; Gunzer, Florian

doi:10.1016/j.anaerobe.2019.05.001

Cited by 8 publications

(7 citation statements)

References 17 publications

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“…Cases of periprosthetic infection and aortic cross homograft myographic pseudoaneurysm, aspiration pneumonia and hardware-associated soft tissue infection caused by R. peoriensis have been reported [10][11][12][13]. R. peoriensis was detected in multiple bone samples from the right talus and tibia in 2019 [14]. In most R. peoriensis infections an association with trauma or surgery has been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

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First pediatric case of osteomyelitis caused by Robinsoniella peoriensis

İnal

Karagöz

Turhan

et al. 2021

AMicr

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Robinsoniella peoriensis is a gram-positive, spore-forming, anaerobic rod. In our study, we isolated R. peoriensis from an open fracture of the left distal tibia of a three-year-old male patient. Tissue anaerobic culture was positive for R. peoriensis. It was identified with both matrix-assisted laser desorption ionization time-of-flight mass spectrometry and confirmed via 16S rRNA gene sequencing. The patient responded to ampicillin-sulbactam and amikacin antibiotic therapy. Antimicrobial susceptibility testing should be performed to guide the choice of treatment. To the best of our knowledge, this is the first report of R. peoriensis osteomyelitis in a pediatric patient and first report from Turkey.

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Section: Discussionmentioning

confidence: 99%

“…In most R. peoriensis infections an association with trauma or surgery has been demonstrated. [7,13,14]. Summary of R. peoriensis cases reported in Table 2.…”

Section: Discussionmentioning

confidence: 99%

First pediatric case of osteomyelitis caused by Robinsoniella peoriensis

İnal

Karagöz

Turhan

et al. 2021

AMicr

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“…Compared with the GM composition before ovariectomy, Clostridium, Robinsoniella, Coprococcus, and Dialister increased significantly at 12 weeks after ovariectomy. Robinsoniella and Dialister are associated with bone infection and bone volume loss, respectively [28][29][30]. In addition, the trend of DNA repair and CRISPR genes shows an increase during the first four weeks after ovariectomy, indicating that estrogen deficiency-related inflammatory reactions may lead to impairment of DNA repair [31].…”

Section: Discussionmentioning

confidence: 99%

Structural and functional changes of gut microbiota in ovariectomized rats and their correlations with altered bone mass

Qin

Hao

et al. 2020

Aging

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As a critical factor involved in the maintenance of physiological homeostasis, the gut microbiota (GM) reportedly plays a key role in bone development. To date, the association between the GM and steroid deficiency-induced osteoporosis remains poorly understood. Forty female Sprague Dawley rats were divided into an ovariectomy (OVX) or control group. We performed 16S rRNA and metagenome sequencing, to compare diversity, taxonomic differences, and functional genes. The GM composition did not change in the control group and the number of operational taxonomic units increased significantly following ovariectomy. Alpha diversity, determined by ACE estimator, CHAO estimator, the Shannon index, and the Simpson index showed an increasing trend after ovariectomy. Samples in the OVX group were well clustered both pre- and post-ovariectomy, as demonstrated by principal coordinate 1 (PC1) and PC2. Functional genes of GM, including those involved in synthesis and metabolism of carbohydrates and nucleotides, microbial structure, and heme, as well as hemin uptake and utilization, increased at the early stage of osteoporosis. We observed that Ruminococcus flavefaciens exhibited the greatest variation in abundance among the GM and this was also associated with osteoclastic indicators and the estrobolome. Specific changes in fecal microbiota are associated with the pathogenesis of steroid deficiency-induced osteoporosis.

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“…The literature search of the PubMed and Scopus databases yielded 52 non-duplicate studies. After screening all potentially eligible studies and the snowball procedure, only 14 studies met the inclusion criteria and were considered for data extraction [ 11 , 12 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Figure 1 shows the flow diagram of study inclusion.…”

Section: Resultsmentioning

confidence: 99%

“…The first one is trauma with fractures, which necessitates orthopedic surgery. Indeed, six such patients were identified in the present review [ 12 , 21 , 22 , 24 , 25 ]. In most of these cases, trauma led to open fractures that could allow the inoculation of environmental pathogens in the patients’ bones or joints.…”

Section: Discussionmentioning

confidence: 99%

Robinsoniella peoriensis Infections in Humans—A Narrative Review

Ioannou,

Baliou,

Kofteridis

2024

Antibiotics

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Robinsoniella peoriensis is a Gram-positive, strictly anaerobic, spore-forming, rod-shaped bacterium belonging to the phylum Firmicutes and the family Lachnospiraceae. Until now, R. peoriensis is the only species of its genus. It was first isolated in 2003 during a study into the flora of lagoons and manure pits. Given the rarity of this microorganism and the sparse information in the literature about its way of transmission, the way to diagnose its infections and identify it in the microbiology laboratory, and its public health relevance, the present study aimed to identify all the published cases of Robinsoniella, describe the epidemiological, clinical, and microbiological characteristics, and provide information about its antimicrobial resistance, treatment, and outcomes. A narrative review was performed based on a Pubmed/Medline and Scopus databases search. In total, 14 studies provided data on 17 patients with infections by Robinsoniella. The median age of patients was 63 years and 47% were male. The most common types of infection were bone and joint infections, bacteremia, infective endocarditis, and peritonitis. The only isolated species was R. peoriensis, and antimicrobial resistance to clindamycin was 50%, but was 0% to the combination of piperacillin with tazobactam, aminopenicillin with a beta-lactamase inhibitor, and metronidazole which were the most commonly used antimicrobials for the treatment of these infections. The overall mortality depends on the type of infection and is notable only for bacteremia, while all other infections had an optimal outcome. Future studies should better assess these infections’ clinical and epidemiological characteristics and the mechanisms of the antimicrobial resistance of this microorganism from a mechanistic and genetic perspective.

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Detection of Robinsoniella peoriensis in multiple bone samples of a trauma patient

Cited by 8 publications

References 17 publications

First pediatric case of osteomyelitis caused by Robinsoniella peoriensis

First pediatric case of osteomyelitis caused by Robinsoniella peoriensis

Structural and functional changes of gut microbiota in ovariectomized rats and their correlations with altered bone mass

Robinsoniella peoriensis Infections in Humans—A Narrative Review

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