Detection of security relevant substances within the cooperative project SAFE XUV

Realization of In-Source Collision-Induced Dissociation in Single-Photon Ionization Time-of-Flight Mass Spectrometry and Its Application for Differentiation of Isobaric Compounds

“…Tandem mass spectrometry (MS/ MS) instruments, such as ion trap and triple quadrupole, are capable of acquiring both the parent ion and the CID-generated fragment ion mass spectra by first performing an intermediate procedure of ion isolation in the collision cell. Some facilities coupling of SPI sources and ion trap mass spectrometers have been developed by several groups for online monitoring of organic compounds, 22−26 and the ability of MS/MS via CID in the ion trap to differentiate isobars and isomers were fully demonstrated by Zimmermann et al 25 and Goeringer et al 26 Low-energy CID of ionized species can also be realized by increasing the energy of the ions as they are transferred from the ion source to the mass analyzer. The excess energy exerted on the ions by elevating the dc voltage applied to the electrodes enables CID to be carried out in the ion source or the ion transporting path, such as the region between sample cone and skimmer, without the need for ion isolation procedure.…”