Detection of shrew-borne hantavirus in Eurasian pygmy shrew (Sorex minutus) in Central Europe

Radosa, Lukáš; Schlegel, Mathias; Gebauer, Petra; Ansorge, Hermann; Heroldová, Marta; Jánová, Eva; Stanko, Michał; Mošanský, Ladislav; Fričová, Jana; Pejčoch, M; Suchomel, Josef; Purchart, Luboš; Groschup, Martin H.; Krüger, Detlev H.; Ulrich, Rainer G.; Klempa, Boris

doi:10.1016/j.meegid.2013.04.008

Cited by 43 publications

(32 citation statements)

References 28 publications

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“…This lineage is further subdivided into two Old World lineages and one North American lineage (Figure 3). These overall patterns concur across several phylogenetic presentations [20,22,26,31,43]. …”

Section: New Hosts Discovered Redefining Hantavirus Evolutionary Trasupporting

confidence: 53%

Reconstructing the evolutionary origins and phylogeography of hantaviruses

Bennett

Kang

et al. 2014

Trends in Microbiology

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Rodents have long been recognized as the principal reservoirs of hantaviruses. However, with the discovery of genetically distinct and phylogenetically divergent lineages of hantaviruses in multiple species of shrews, moles, and insectivorous bats from widely separated geographic regions, a far more complex landscape of hantavirus host distribution, evolution, and phylogeography is emerging. Detailed phylogenetic analyses, based on partial and full-length genomes of previously described rodent-borne hantaviruses and newly detected non-rodent-borne hantaviruses, indicate an Asian origin and support the emerging concept that ancestral non-rodent mammals may have served as the hosts of primordial hantaviruses.

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Section: New Hosts Discovered Redefining Hantavirus Evolutionary Trasupporting

confidence: 53%

Reconstructing the evolutionary origins and phylogeography of hantaviruses

Bennett

Kang

et al. 2014

Trends in Microbiology

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“…Genetically distinct hantaviruses have also been detected in other Sorex species, including Ash River virus in the North American masked shrew (Sorex cinereus) and Jemez Springs virus in the dusky shrew (Sorex monticolus) (Arai et al 2008a), Kenkeme virus in the Asian flat-skulled shrew (Sorex roboratus) (Kang et al 2010), Asikkala virus in the Eurasian pygmy shrew (Sorex minutus) (Radosa et al 2013), Yakeshi virus in the taiga shrew (Sorex isodon) (Guo et al 2013), Qian Hu Shan virus in the stripe-back shrew (Sorex cylindricauda) (Zuo et al 2014), and Sarufutsu virus in the long-clawed shrew (Sorex unguiculatus) (Arai et al unpublished data).…”

Section: Introductionmentioning

confidence: 99%

Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens)

Arai

Kang

et al. 2016

Vector-Borne and Zoonotic Diseases

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Although based on very limited M and L segment sequences, Artybash virus (ARTV) was proposed previously as a unique hantavirus harbored by the Laxmann's shrew (Sorex caecutiens). To verify this conjecture, lung tissues from 68 Laxmann's shrews, captured during 2006 to 2014 in eastern Siberia, Russia, and Hokkaido, Japan, were analyzed for ARTV RNA using reverse transcription polymerase chain reaction (RT-PCR). ARTV RNA was detected in six Laxmann's shrews. Pairwise alignment and comparison of partial-and full-length S, M, and L segment sequences from these Laxmann's shrews, as well as phylogenetic analyses, using maximum likelihood and Bayesian methods indicated that ARTV was distinct from other soricine shrew-borne hantaviruses and representative hantaviruses harbored by rodents, moles, and bats. Taxonomic identity of the ARTVinfected Laxmann's shrews was confirmed by full-length cytochrome b mitochondrial DNA sequence analysis. Our data indicate that the hantavirus previously known as Amga virus (MGAV) represents genetic variants of ARTV. Thus, the previously proposed designation of ARTV/MGAV should be replaced by ARTV.

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“…And in a comprehensive phylogeographic study of SWSV in Sorex species in Central Europe, SWSV exhibited distinct geographic-specific clustering in Eurasian common shrews (Schlegel et al, 2012b). Moreover, a genetically related but distinct hantavirus, named Asikkala virus (ASIV), has been found recently in the Eurasian pygmy shrew (Radosa et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Co-circulation of soricid- and talpid-borne hantaviruses in Poland

Gu¹,

Hejduk²,

Markowski³

et al. 2014

Infection, Genetics and Evolution

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Previously, we reported the discovery of a genetically distinct hantavirus, designated Boginia virus (BOGV), in the Eurasian water shrew (Neomys fodiens), as well as the detection of Seewis virus (SWSV) in the Eurasian common shrew (Sorex araneus), in central Poland. In this expanded study of 133 shrews and 69 moles captured during 2010–2013 in central and southeastern Poland, we demonstrate the co-circulation of BOGV in the Eurasian water shrew and SWSV in the Eurasian common shrew, Eurasian pygmy shrew (Sorex minutus) and Mediterranean water shrew (Neomys anomalus). In addition, we found high prevalence of Nova virus (NVAV) infection in the European mole (Talpa europaea), with evidence of NVAV RNA in heart, lung, liver, kidney, spleen and intestine. The nucleotide and amino acid sequence variation of the L segment among the SWSV strains was 0–18.8% and 0–5.4%, respectively. And for the 38 NVAV strains from European moles captured in Huta Dłutowska, the L-segment genetic similarity ranged from 94.1–100% at the nucleotide level and 96.3–100% at the amino acid level. Phylogenetic analyses showed geographic-specific lineages of SWSV and NVAV in Poland, not unlike that of rodent-borne hantaviruses, suggesting long-standing host-specific adaptation. The co-circulation and distribution of BOGV, SWSV and NVAV in Poland parallels findings of multiple hantavirus species coexisting in their respective rodent reservoir species elsewhere in Europe. Also, the detection of SWSV in three syntopic shrew species resembles spill over events observed among some rodent-borne hantaviruses.

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Detection of shrew-borne hantavirus in Eurasian pygmy shrew (Sorex minutus) in Central Europe

Cited by 43 publications

References 28 publications

Reconstructing the evolutionary origins and phylogeography of hantaviruses

Reconstructing the evolutionary origins and phylogeography of hantaviruses

Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens)

Co-circulation of soricid- and talpid-borne hantaviruses in Poland

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