New types of Thick Gaseous Electron Multipliers (THGEMs) made of PCB-type substrates, including Ceramic, Kapton, PTFE, and in addition to FR-4, were developed for applications requiring low neutron absorption, scattering, and low natural radioactivity, such as the THGEM-based neutron detector, and the THGEM-based gaseous multiplier (GPM). Using Geant4 simulation, the result of the total neutron absorption and scattering ratio of bare substrate is Kapton(high) > FR-4 > Ceramic > PTFE (low). The Ceramic and PTFE substrates have lower ratios about 0.707% and 0.635% per layer(0.2 mm thick) respectively. The gamma-induced electron background is the reverse, Ceramic > PTFE > FR-4 > Kapton, from 1.5% to 0.7% at 1.0 MeV, which induces highest electron background in the range of 0∼7 MeV. The natural radioactivity background was measured for these types of substrate samples. The Ceramic substrate has lower radioactivity, 232 Th = 8.8 ± 0.9 Bq/kg, 238 U = 6.3 ± 0.9 Bq/kg, and 40 K is too low to be detected. Some THGEM samples were produced by these four types of substrates in the same shape: 0.2-mm thickness, 0.2-mm hole diameter, 0.6-mm pitch, and 70-µm rim. The performances of these new substrate THGEMs are promising. The effective gain is at the 10 4 level and the gain was stable during more than 100 hours continuous test. The energy resolution @ Ar+IsoB = 97:3 is at the level of 20% to 27%. These new substrate THGEMs are available in 200×200 mm 2 size and even larger, some of them are applied to neutron flux monitor detector and gaseous photomultipliers (GPM).