Detection of specific hydatid antigens and antibodies in serum and urine of experimentally infected sheep

Ghorbanpoor, Masoud; Jalali, Mohammad Hossein Razi; Rad, N Hoghooghi; Nabavi, L; Zadeh, Samad; Rafiei, Abdollah; Hajikolaei, Mohammad Rahim Haji

doi:10.1016/j.vetpar.2006.06.018

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Immunodiagnosis Of Cystic Echinococcosis In Intermediate Hos1

Progress In the Immunological Diagnosis Of Hydatid Disease I1

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“…Sensitivity (60%) was less but specificity was higher (94%) with the HCF-ELISA (Simsek and Koroglu, 2004). Ghorbanpoor et al (2006) were able to detect specific circulating antigens or antibodies in the serum and urine of 13 experimentally infected sheep.…”

Section: Immunodiagnosis Of Cystic Echinococcosis In Intermediate Hosmentioning

confidence: 96%

Recent Advances in the Immunology and Serological Diagnosis of Echinococcosis

Zhang¹,

Li²,

Lin³

et al. 2012

Serological Diagnosis of Certain Human, Animal and Plant Diseases

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Section: Immunodiagnosis Of Cystic Echinococcosis In Intermediate Hosmentioning

confidence: 96%

Recent Advances in the Immunology and Serological Diagnosis of Echinococcosis

Zhang¹,

Li²,

Lin³

et al. 2012

Serological Diagnosis of Certain Human, Animal and Plant Diseases

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“…In experimentally infected sheep, antibodies to hydatid antigens can be detected relatively early post‐infection and persist for at least 4 years . In general, the dual problems of insensitivity and serological cross‐reactions between E. granulosus and other cestodes limit the specific diagnosis of hydatid infection in sheep when using crude or fractionated parasite antigens, secretions produced during in vitro cultivation of protoscoleces or from mouse hydatid cyst membranes .…”

Section: Progress In the Immunological Diagnosis Of Hydatid Disease Imentioning

confidence: 99%

Immunodiagnosis of sheep infections with Echinococcus granulosus: in 35 years where have we come?

McManus

2014

Parasite Immunology

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published in 1979 a seminal paper in the first issue of Parasite Immunology describing their efforts to determine whether the arc 5 precipitin band, formed when test human serum is reacted against electrophoresed hydatid cyst fluid antigen, would be a suitable immunodiagnostic test for the identification of sheep infected with Echinococcus granulosus. Although they found antibodies to arc 5 in the sera of hydatid-infected sheep, the sera of some sheep harbouring Taenia ovis and T. hydatigena also precipitated the hydatid cyst fluid arc 5 antigen, so they concluded arc 5 antibodies were not suitable for the specific immunodiagnosis of E. granulosus infection in sheep in New Zealand. Subsequent work has shown that the existence of multiple infections with different taeniid species, antigenic cross-reactivity between these related parasites and the low level of specific antibody response to infection continue to hinder efforts to improve the diagnosis of hydatid infection in sheep and other natural intermediate hosts, thereby preventing the development of any practical test. In particular, the poor antibody response of ruminants to naturally acquired hydatid infection may prove an insurmountable barrier in future efforts to develop a reliable and accurate immunological test.

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