Detection of Sunlight Exposure with Solar-Sensitive Liposomes that Capture and Release Food Dyes

Miranda, Dyego; Li, Nasi; Li, Changning; Stefanovic, Filip; Atilla‐Gokcumen, G. Ekin; Lovell, Jonathan F.

doi:10.1021/acsanm.8b00435

Cited by 10 publications

(8 citation statements)

References 52 publications

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“…To expedite release of CIP from CIP PoP liposomes, an unsaturated lipid DOPC was titrated into CIP loaded PoP liposomes of formulation DSPC:CHOL:PoP (molar ratio 65:33:2) replacing DSPC and the NIR light-triggered release of CIP was tested. In previous studies, it has been shown that light-triggered cargo release from PoP liposomes is greatly accelerated by the inclusion of a small amount of DOPC or other unsaturated lipids [28,[59][60][61]. Accelerated light-triggered cargo coincides with oxidation of the unsaturated lipids, which presumably leads to faster bilayer destabilization.…”

Section: Dopc Accelerates Light-triggered Drug Releasementioning

confidence: 98%

Loading and releasing ciprofloxacin in photoactivatable liposomes

Ghosh

Carter

et al. 2019

Biochemical Engineering Journal

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We demonstrate that ciprofloxacin can be actively loaded into liposomes that contain small amounts of porphyrin-phospholipid (PoP). PoP renders the liposomes photoactivatable, so that the antibiotic is released from the carrier under red light irradiation (665 nm). The use of 2 molar % PoP in the liposomes accommodated active loading of ciprofloxacin. Further inclusion of 2 molar % of an unsaturated phospholipid accelerated light-triggered drug release, with more than 90 % antibiotic release from the liposomes occurring in less than 30 seconds. With or without laser treatment, ciprofloxacin PoP liposomes inhibited the growth of Bacillus subtilis in liquid media, apparently due to uptake of the liposomes by the bacteria. However, when liposomes were first separated from smaller molecules with centrifugal filtration, only the filtrate from laser-treated liposomes was bactericidal, confirming effective release of active antibiotic. These results establish the feasibility of remote loading antibiotics into photoactivatable liposomes, which could lead to opportunities for enhanced localized antibiotic therapy.

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Section: Dopc Accelerates Light-triggered Drug Releasementioning

confidence: 98%

Loading and releasing ciprofloxacin in photoactivatable liposomes

Ghosh

Carter

et al. 2019

Biochemical Engineering Journal

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“…The traditional tumor treatments, such as chemotherapy, radiotherapy, and surgery, often induce severe side effects to patients . Thus, the development of noninvasive and efficient therapeutic treatments for cancers is highly urgent .…”

Section: Introductionmentioning

confidence: 99%

Facile Preparation of Phthalocyanine-Based Nanodots for Photoacoustic Imaging and Photothermal Cancer Therapy In Vivo

Yue

Cheng

et al. 2020

ACS Biomater. Sci. Eng.

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The development of near-infrared (NIR)-absorbing nanoagents for personalized multifunctional phototheranostics has attracted considerable attention in the past decade. Recently, the organic nanomaterials with good biosafety are considered as promising phototheranostic agents, while their facile synthesis remains challenging. Inspired by the preparation of carbon nanodots, we fabricate the NIR-absorbing phthalocyanine-based nanodots (ZnPc-NDs) using a facile method for multifunctional phototheranostics. The significant aggregation of phthalocyanines in nanodots induces a complete fluorescence quenching, which affords a high photothermal conversion efficiency (η = 45.7%). The ZnPc-NDs disperse very well in water media with an average diameter around 80 nm. Further conjugation of biotin on the surface of ZnPc-NDs affords tumor-targeting phthalocyanine nanodots (ZnPc-BT). The ZnPc-BT are demonstrated with favorable biocompatibility, intense photoacoustic signals, high tumor accumulation, and effective tumor suppression in vivo. This Article provides a new insight for further developing nanomedicines with imaging and therapeutic functions to treat cancers precisely and effectively.

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“…Singlet oxygen generated in the bilayer can oxidize unsaturated lipids, leading to membrane permeabilization 36 ,. 37 …”

Section: Introductionmentioning

confidence: 99%

Binding of an amphiphilic phthalocyanine to pre-formed liposomes confers light-triggered cargo release

et al. 2018

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Liposomes are able to load a range of cargos and have been used for drug delivery applications, including for stimuli-triggered drug release. Here, we describe an approach for imparting near infrared (NIR) light-triggered release to pre-formed liposomes, using a newly-synthesized cationic, amphiphilic phthalocyanine. When simply mixed in aqueous solution with cargo-loaded liposomes, the cationic amphiphilic phthalocyanine, but not a cationic hydrophilic azaphthalocyanine, spontaneously incorporates into the liposome bilayer. This enables subsequent release of loaded cargo (doxorubcin or basic orange) upon irradiation with NIR light. The rate of release could be altered by varying the amount of photosensitizer added to the liposomes. In the absence of NIR light exposure, stable cargo loading of the liposomes was maintained. Introduction

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Detection of Sunlight Exposure with Solar-Sensitive Liposomes that Capture and Release Food Dyes

Cited by 10 publications

References 52 publications

Loading and releasing ciprofloxacin in photoactivatable liposomes

Loading and releasing ciprofloxacin in photoactivatable liposomes

Facile Preparation of Phthalocyanine-Based Nanodots for Photoacoustic Imaging and Photothermal Cancer Therapy In Vivo

Binding of an amphiphilic phthalocyanine to pre-formed liposomes confers light-triggered cargo release

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