Detection of the mycotoxin citrinin using silver substrates and Raman spectroscopy

Singh, Dheeraj K.; Ganbold, Erdene‐Ochir; Cho, Eun-Min; Cho, Kwang‐Hwi; Kim, Doseok; Choo, Jaebum; Kim, Sehun; Lee, Cheol Min; Yang, Sung Ik; Joo, Sang‐Woo

doi:10.1016/j.jhazmat.2013.11.041

Cited by 45 publications

(20 citation statements)

References 37 publications

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“…Our compiled data [22] proved that the 632.8 nm wavelength is also applicable in the study of adsorption on AgNPs when the absorption becomes redshifted after the occurrence of aggregation as revealed in Fig. 2.…”

Section: Quantum Mechanical Calculations Of Tautomeric Forms Of 6a-7dapmentioning

confidence: 53%

Raman spectroscopic study of 6-amino-7-deazapurine

Ganbold

Kang

Joo

2015

Vibrational Spectroscopy

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Section: Quantum Mechanical Calculations Of Tautomeric Forms Of 6a-7dapmentioning

confidence: 53%

Raman spectroscopic study of 6-amino-7-deazapurine

Ganbold

Kang

Joo

2015

Vibrational Spectroscopy

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“…Quantitation has been developed for at least B 1 [173]. Mycotixin citrinin, which is produced by several fungi species, can also be detected in trace amounts [187]. There are severe consequences for mycotoxin consumption for both humans and domesticated animals.…”

Section: Sers Of Small Moleculesmentioning

confidence: 99%

Fundamentals and applications of SERS-based bioanalytical sensing

et al. 2017

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Abstract:Plasmonics is an emerging field that examines the interaction between light and metallic nanostructures at the metal-dielectric interface. Surface-enhanced Raman scattering (SERS) is a powerful analytical technique that uses plasmonics to obtain detailed chemical information of molecules or molecular assemblies adsorbed or attached to nanostructured metallic surfaces. For bioanalytical applications, these surfaces are engineered to optimize for high enhancement factors and molecular specificity. In this review we focus on the fabrication of SERS substrates and their use for bioanalytical applications. We review the fundamental mechanisms of SERS and parameters governing SERS enhancement. We also discuss developments in the field of novel SERS substrates. This includes the use of different materials, sizes, shapes, and architectures to achieve high sensitivity and specificity as well as tunability or flexibility. Different fundamental approaches are discussed, such as label-free and functional assays. In addition, we highlight recent relevant advances for bioanalytical SERS applied to small molecules, proteins, DNA, and biologically relevant nanoparticles. Subsequently, we discuss the importance of data analysis and signal detection schemes to achieve smaller instruments with low cost for SERS-based point-of-care technology developments. Finally, we review the main advantages and challenges of SERS-based biosensing and provide a brief outlook.

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“…Raman spectroscopy was performed with a HORIBA Jobin Yvon HR800 spectrometer with 785 nm diode laser as source. Spectral data was collected using a 10× microscope objective over the range It has been shown that the spectrum of Mycotoxin can be achieved using GNPs and SERS within a few minutes [35,36]. In order to confirm fungal infection by Raman spectroscopy, Surface Enhanced Raman of gold nanoparticles incubated with fungi were measured according to the preview methods of gold nanostars for surface-enhanced Raman scattering [35,36,37].…”

Section: Raman Spectral Analysis To Confirm Fungal Contaminationmentioning

confidence: 99%

Plasmonic gold nanoparticles for detection of fungi and human cutaneous fungal infections

Sojinrin¹,

Conde

Liu³

et al. 2017

Anal Bioanal Chem

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Fungi, which are common in the environment, can cause a multitude of diseases. Warm, humid conditions allow fungi to grow and infect humans via the respiratory, digestive and reproductive tracts, genital area and other bodily interfaces. Fungi can be detected directly by microscopy, using the potassium hydroxide test, which is the gold standard and most popular method for fungal screening. However, this test requires trained personnel operating specialist equipment, including a fluorescent microscope and culture facilities. As most acutely infected patients seek medical attention within the first few days of symptoms, the optimal diagnostic test would be rapid and self-diagnostic simplifying and improving the therapeutic outcome. In suspensions of gold nanoparticles, Aspergillus niger can cause a colour change from red to blue within 2 min, as a result of changes in nanoparticle shape. A similar colour change was observed in the supernatant of samples of human toenails dispersed in water. Scanning electron microscopy, UV/Vis and Raman spectroscopy were employed to monitor the changes in morphology and surface plasmon resonance of the nanoparticles. The correlation of colour change with the fungal infection was analysed using the absorbance ratio at 520 nm/620 nm. We found a decrease in the ratio when the fungi concentration increased from 1 to 16 CFU/mL, with a detection limit of 10 CFU/mL. The test had an 80% sensitivity and a 95% specificity value for the diagnosis of athlete's foot in human patients. This plasmonic gold nanoparticle-based system for detection of fungal infections measures the change in shape of gold nanoparticles and generates coloured solutions with distinct tonality. Our application has the potential to contribute to self-diagnosis and hygiene control in laboratories/hospitals with fewer resources, just using the naked eye. Graphical abstract Colorimetric method for fungi detection with gold nano particles.

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Detection of the mycotoxin citrinin using silver substrates and Raman spectroscopy

Cited by 45 publications

References 37 publications

Raman spectroscopic study of 6-amino-7-deazapurine

Raman spectroscopic study of 6-amino-7-deazapurine

Fundamentals and applications of SERS-based bioanalytical sensing

Plasmonic gold nanoparticles for detection of fungi and human cutaneous fungal infections

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