This research utilizes metaheuristic optimization inspired by the Egyptian Vulture Optimization (EVO) technique. Biomedical image segregation is developed to reduce the complex association of hyperparameters of Convolutional Neural networks (CNN). The complex attributes of CNN include the type of kernel, size of the kernel, size of the batch, epoch counts, momentum, learning rate, activation function, convolution layer, and dropout. However, the life cycle of an Egyptian vulture influences the optimization technique to resolve complexity and increase the accuracy of CNN. The proposed CNN-based EVO model was evaluated in comparison to ANN-based and deep learning-based classifiers utilizing brain MRI image datasets. The results achieved have confirmed the efficiency and performance of the proposed CNN-based EVO model, in which the average detection accuracy and precision were 93% and 95%, respectively.