Detection of uncharged or feebly charged small molecules by field-effect transistor biosensors

Ah, Chil Seong; Park, Chan Woo; Yang, Jong‐Heon; Lee, Joon Sung; Kim, Wan‐Joong; Chung, Kwang Hyo; Choi, Yo Han; Baek, In Bok; Kim, Jungho; Sung, Gun Yong

doi:10.1016/j.bios.2012.01.010

Cited by 29 publications

(7 citation statements)

References 25 publications

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“…In the context of EG-CNTFET-based biosensors, there is minimal literature on the validation of the biosensors in environments with varying buffer composition, pH, and, more importantly, physiologically relevant environments. The sensing capability of EG-FETs is usually demonstrated in PBS (pH ¼ 7.4), 13,20,54 as this closely mimics physiological solutions. 12 The third major challenge in EG-CNTFET-based biosensors is related to the Debye screening: as already discussed in Sec.…”

Section: Conclusion-present Issues and Challengesmentioning

confidence: 99%

“…8 The resulting label-free detection strategy (i.e., no need to attach fluorescent or radioactive molecules to the targeted analyte(s) to perform the measurements) [9][10][11] enables integration into low-cost miniaturized portable systems, allowing both laboratory analysis and point-of-care testing. 12 These advantages facilitate the use of biosensors in diverse fields such as biomedicine and health care, 10,[13][14][15][16][17] wearable electronics, 18,19 food and beverage quality control, 15,20,21 circuit applications, 22 and precision agriculture. 23,24 Biosensors using field-effect transistors (FETs) as biotransduction elements are one of the most promising class of electrochemical devices.…”

Section: Introductionmentioning

confidence: 99%

“…8 Specific examples of electrochemical biosensors using FET transduction can be found in several recent papers. 10,[13][14][15][16][17]20,21,23,[29][30][31][32] To date, the most widely used FET technology is constituted by the so-called metal-oxide-semiconductor FETs (MOSFETs), where the gate contact is insulated from the silicon (Si)semiconducti ngchannel by a thin silicon dioxide (SiO 2 )l a y e r . 33 FET-based biosensors can be realized using different device configurations such as so-called backgated (BG-FET), 34,35 dual-gated (DG-FET), 36,37 or electrolyte-gated FETs (EG-FETs).…”

Section: Introductionmentioning

confidence: 99%

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Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications

Shkodra

Petrelli

Angeli

et al. 2021

Applied Physics Reviews

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Nowadays, there is a high demand for sensitive and selective real-time analytical methods suitable for a wide range of applications, from personalized telemedicine, drug discovery, food safety, and quality control, to defense, security, as well as environmental monitoring. Biosensors are analytical devices able to detect bio-chemical analytes (e.g., neurotransmitters, cancer biomarkers, bio-molecules, and ions), through the combination of a bio-recognition element and a bio-transduction device. The use of customized bio-recognition elements such as enzymes, antibodies, aptamers, and ion-selective membranes facilitates achieving high selectivity. Among the different bio-transduction devices currently available, electrolyte-gated field-effect transistors, in which the dielectric is represented by an ionic liquid buffer solution containing the targeted analyte, are gaining increasing attention. Indeed, these biotransduction devices are characterized by superior electronic properties and intrinsic signal amplification that allow the detection of a wide rangeofbiomolecules with high sensitivity (down to pM concentration). A promising semiconducting material for bio-transduction devices is represented by carbon nanotubes, due to their unique electrical properties, nanosize, bio-compatibility, and their simple low-cost processability. This work provides acomprehensive and critical review of electrolyte-gated carbon nanotube field-effect transistor-based biosensors. First, an introduction to these bio-sensing devices is given. Next, the device configurations and operating principles are presented, and the most used materials and processes are reviewed with a particular focus on carbon nanotubes as the active material. Subsequently, different functionalization strategies reported in the literature, based on enzymes, antibodies, aptamers, and ion-selective membranes, are analyzed critically. Finally, present issues and challenges faced in the area are investigated,theconclusions are drawn, and a perspective outlook over the field of bio-sensing technologies, in general, is provided.

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Section: Conclusion-present Issues and Challengesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications

Shkodra

Petrelli

Angeli

et al. 2021

Applied Physics Reviews

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show abstract

“…In addition, this process no longer made their techniques label-free. Subsequent years have witnessed a continuous development of FET sensors for tiny molecules with no/feeble charge and low molecular weight including trinitrotoluene [114], glucose [115,116], aflatoxin-B1 [117], zearalenone [117], ochratoxin-A [117]. Fundamental research on the interactions between small molecules and FETs has been the focus of recent scientific attention [118].…”

Section: Aptamers As Bio-receptors In Fet Biosensors For Small Molecumentioning

confidence: 99%

Predicting Future Prospects of Aptamers in Field-Effect Transistor Biosensors

Chen

2020

Molecules

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Aptamers, in sensing technology, are famous for their role as receptors in versatile applications due to their high specificity and selectivity to a wide range of targets including proteins, small molecules, oligonucleotides, metal ions, viruses, and cells. The outburst of field-effect transistors provides a label-free detection and ultra-sensitive technique with significantly improved results in terms of detection of substances. However, their combination in this field is challenged by several factors. Recent advances in the discovery of aptamers and studies of Field-Effect Transistor (FET) aptasensors overcome these limitations and potentially expand the dominance of aptamers in the biosensor market.

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“…Ah et al [63] demonstrated an interesting sensor based on the Si field-effect transistor (FET) for AFB 1 sensing. The signal was enhanced by Au nanoparticle charges under dry sensing conditions during an indirect competitive immunogold assay.…”

Section: Applicationsmentioning

confidence: 99%

Mycotoxin Determination in Foods Using Advanced Sensors Based on Antibodies or Aptamers

Zhang

et al. 2016

Toxins

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Mycotoxin contamination threatens health and life of humans and animals throughout the food supply chains. Many of the mycotoxins have been proven to be carcinogens, teratogens and mutagens. The reliable and sensitive sensing methods are requested to monitor mycotoxin contamination. Advanced sensors based on antibodies or aptamers boast the advantages of high sensitivity and rapidity, and have been used in the mycotoxin sensing. These sensors are miniaturized, thereby lowering costs, and are applicable to high-throughput modes. In this work, the latest developments in sensing strategies for mycotoxin determination were critically discussed. Optical and electrochemical sensing modes were compared. The sensing methods for single mycotoxin or multiple mycotoxins in food samples were reviewed, along with the challenges and the future of antibody or aptamer-based sensors. This work might promote academic studies and industrial applications for mycotoxin sensing.

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Detection of uncharged or feebly charged small molecules by field-effect transistor biosensors

Cited by 29 publications

References 25 publications

Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications

Electrolyte-gated carbon nanotube field-effect transistor-based biosensors: Principles and applications

Predicting Future Prospects of Aptamers in Field-Effect Transistor Biosensors

Mycotoxin Determination in Foods Using Advanced Sensors Based on Antibodies or Aptamers

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