Detection of vitellogenin, an endocrine disrupter biomarker, using AlGaN/GaN high electron mobility transistors

Chu, Byung Hwan; Chang, C. Y.; Kroll, Kevin J.; Denslow, Nancy D.; Wang, Yulin; Pearton, S. J.; Lin, Jing-Fung; Dabiran, A. M.; Wowchak, A. M.; Cui, B.; Chow, P. P.; Johnson, J. W.; Rajagopal, P.; Roberts, John C.; Piner, E. L.; Linthicum, K. J.; Ren, F.

doi:10.1002/pssc.201001171

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…Once again, the high surface area of nanowires provides an ideal approach for enzymatic detection of biochemically important substances [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

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Wide Bandgap Semiconductor One-Dimensional Nanostructures for Applications in Nanoelectronics and Nanosensors

Pearton

Ren

2013

Nanomaterials and Nanotechnology

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Wide bandgap semiconductor ZnO, GaN and InN nanowires have displayed the ability to detect many types of gases and biological and chemical species of interest. In this review, we give some recent examples of using these nanowires for applications in pH sensing, glucose detection and hydrogen detection at ppm levels. The wide bandgap materials offer advantages in terms of sensing because of their tolerance to high temperatures, environmental stability and the fact that they are usually piezoelectric. They are also readily integrated with wireless communication circuitry for data transmission.

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Section: Discussionmentioning

confidence: 99%

“…There is also interest in applying these to biomarker detection [21][22][23][24][25][26][27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Wide Bandgap Semiconductor One-Dimensional Nanostructures for Applications in Nanoelectronics and Nanosensors

Pearton

Ren

2013

Nanomaterials and Nanotechnology

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“…An overlooked potential application of the GaN HEMT structure is sensors (Pearton et al , 2010;Chu et al, 2011;Lo et al , 2011Lo et al , , 2012. The high electron sheet carrier concentration of nitride HEMTs is induced by piezoelectric polarization of the strained AlGaN layer in the hetero-junction structure of the AlGaN/GaN HEMT and the spontaneous polarization is considerable in wurtzite III-nitrides.…”

Section: © Woodhead Publishing Limited 2013mentioning

confidence: 99%

Recent advances in wide bandgap semiconductor-based gas sensors

Ren

Pearton

2013

Semiconductor Gas Sensors

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“…Much of this work revolves around bio-functionalized AlGaN/GaN high electron mobility transistors (HEMTs), due to the excellent sensing characteristics from the high-density electron channel located near surface (∼25 nm). This type of sensor platform has been used extensively for a wide variety of bio-sensing applications, [44][45][46][47][48][49][50][51][52][53] but suffers from a number of disadvantages, chiefly the high cost of HEMT devices. For protein sensing, one of the major concerns can be the high ionicity of the test solution (secretions/blood/serum).…”

Section: Functionalized Semiconductor Sensorsmentioning

confidence: 99%

Review—Opportunities for Rapid, Sensitive Detection of Troponin and Cerebral Spinal Fluid Using Semiconductor Sensors

Carey

Lobo

Gebhard

et al. 2019

J. Electrochem. Soc.

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There are opportunities for development of modularized, inexpensive protein biomarker sensors in clinical applications. In this review we focus on two of these, namely early diagnosis of acute myocardial infarction (AMI) and detection of cerebral spinal fluid (CSF). Evaluation of patients with acute chest pain is challenging due to the heterogeneity of the underlying conditions, leading to patients with AMI being mistakenly sent home from emergency rooms or those at low risk for an adverse cardiac event being unnecessarily admitted without precise cardiac biomarker testing. Cardiac troponin I (cTnI) in cardiac muscle tissue is a standard clinical biomarker for AMI, as its concentration rises quickly in the blood during release from myocardial cells following cell death. The time-dependence of the cTnI concentration is the basis of antigen-antibody methodologies such as radioimmunoassay and enzyme-linked immunosorbent assay (ELISA). These methods are time consuming, leading to delays in diagnosis and higher costs. The challenge is to develop a real-time, accurate, low-cost point-of-care heart attack sensor. The coefficient of variation must be precise, within the parameters established by the American College of Cardiology. Similarly, leakage of cerebrospinal fluid (CSF) is a critical condition with a high risk of meningitis and potential mortality. The primary methods of detection for the biomarker β2-Transfferin (B2T) are immunofixation electrophoresis (IFE) and ELISA. Consistent IFE results down to 2 μg/mL can be obtained in patient samples, but requires a minimum 2.5-hour testing period, which is not expedient for real time feedback during surgery in or around the central nervous system. Additionally, to achieve good sensitivity and handle the inherently low concentration of B2T in CSF, lab procedures require samples to be concentrated or run in duplicate to ensure accurate detection. Real time turnaround is on the order of days. To alleviate the slow turn-around times, there is strong interest in electronic detection methods for proteins using biologically functionalized transistors, which provide an electronic readout and are readily integrated with wireless data transmission.

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Detection of vitellogenin, an endocrine disrupter biomarker, using AlGaN/GaN high electron mobility transistors

Cited by 5 publications

References 17 publications

Wide Bandgap Semiconductor One-Dimensional Nanostructures for Applications in Nanoelectronics and Nanosensors

Wide Bandgap Semiconductor One-Dimensional Nanostructures for Applications in Nanoelectronics and Nanosensors

Recent advances in wide bandgap semiconductor-based gas sensors

Review—Opportunities for Rapid, Sensitive Detection of Troponin and Cerebral Spinal Fluid Using Semiconductor Sensors

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