Detection rate and proximal shift tendency of adenomas and serrated polyps: a retrospective study of 62,560 colonoscopies

Chen, Shu‐Ling; Sun, Ke; Chao, Kang; Sun, Yi; Hong, Liru; Weng, Zijin; Chen, Yi; Chen, Minhu; Zhang, Shenghong

doi:10.1007/s00384-017-2951-0

Cited by 11 publications

(9 citation statements)

References 38 publications

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“…Serrated neoplasia appears to be a universal human phenomenon; SSLs and other serrated lesions are found in many disparate populations and ethnic groups. Although most epidemiology studies of SSLs were performed in the United States or Europe, serrated polyps have been reported worldwide, in studies from Korea, 57 Japan, 58,59 China, 60,61 Australia, 62 Peru, 63 Argentina, 64 Russia, 65 Turkey, 66 India, 67 and Nigeria, 68 among other countries. In general, countries that do not screen the population for CRC, or that perform colonoscopies primarily for diagnostic purposes, report lower prevalence values for adenomatous polyps and serrated polyps.…”

Section: Epidemiologymentioning

confidence: 99%

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia

2019

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In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via the serrated pathway. Studies have focused on clarification of categories and molecular features of serrated polyps, as well as endoscopic detection and risk assessment. Guidelines from the World Health Organization propose assigning serrated polyps to categories of hyperplastic polyps, traditional serrated adenomas, and sessile serrated lesions (SSLs). Traditional serrated adenomas and SSLs are precursors to colorectal cancer. The serrated pathway is characterized by mutations in RAS and RAF, disruptions to the Wnt signaling pathway, and widespread methylation of CpG islands. Epidemiology studies of serrated polyps have been hampered by inconsistencies in terminology and reporting, but the prevalence of serrated class polyps is 20%-40% in average-risk individuals; most serrated polyps detected are hyperplastic. SSLs, the most common premalignant serrated subtype, and are found in up to 15% of average-risk patients by highdetecting endoscopists. Variations in rate of endoscopic detection of serrated polyps indicate the need for careful examination, with adequate bowel preparation and sufficient withdrawal times. Risk factors for SSLs include white race, family history of colorectal cancer, smoking, and alcohol intake. Patients with serrated polyps, particularly SSLs and traditional serrated adenomas, have an increased risk of synchronous and metachronous advanced neoplasia. Surveillance guidelines vary among countries, but SSLs and proximal hyperplastic polyps require special attention in assignment of surveillance interval-especially in light of concerns regarding incomplete detection and resection.

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Section: Epidemiologymentioning

confidence: 99%

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia

2019

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“…A total of 86 acromegalic patients (mean age, 43.53±11.78 years; sex, 48.8% females) who underwent complete colonoscopy at our hospitals were included in this study. Of the 86 patients, 35 (18 females, 17 males) had one or more polyps, with a higher prevalence (40.7%) than a general Asian population (17.6–23.9%) of comparable age 17 18 19 20 . The prevalence of polyps increased with age, reaching a peak at ≥60 years.…”

Section: Resultsmentioning

confidence: 99%

Clinical Characteristics and Associated Factors of Colonic Polyps in Acromegaly

Peng

Zhou

et al. 2022

Exp Clin Endocrinol Diabetes

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Purpose To investigate the clinical characteristics and associated factors of colonic polyps in patients with acromegaly. Methods Clinical characteristics and colonoscopy findings of 86 acromegaly patients who received treatment were retrospectively reviewed, and colonoscopy findings and the correlation with growth hormone (GH)-secreting pituitary adenoma (GHPA) volume and hormonal/metabolic levels were analyzed. Results The prevalence of colonic polyps in acromegaly patients was 40.7% and increased significantly with advanced age, especially in those ≥50 years. Multiple polyps (62.8%) and colonic polyps in the left colon (54.2%) were detected more frequently. Compared to acromegaly patients without polyps, those with polyps displayed higher insulin-like growth factor-1 × upper limit of normal (IGF-1×ULN) levels (P=0.03). IGF-1 levels and GHPA volumes in patients with polyps showed increasing trends, although the differences were not significant. GH levels were higher in patients with polyps of diameter ≤5 mm than those with polyps of diameter >5 mm (P=0.031). The univariate and multivariate logistic regression analysis revealed that GHPA volumes (OR: 1.09, 95% CI: 1.01–1.20; P=0.039) and IGF-1×ULN Q2 levels (OR: 6.51, 95% CI: 1.20–44.60; P=0.038) were independent factors for predicting the risk of colonic polyp occurrence in acromegaly patients. A nomogram was prepared to evaluate the risk of colonic polyps in acromegaly patients. Conclusion The acromegalic patients are a population with a high prevalence of colonic polyps. GHPA volumes and IGF-1×ULN levels may be predictors of colonic polyp occurrence.

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“…Clinical features of acromegalic patients with colonic polyps A total of 86 acromegalic patients (mean age, 43.53 ± 11.78 years; sex, 48.8% females) underwent complete colonoscopy. Of the 86 patients, 35 patients (18 females, 17 males) were found to have one or more polyps, with a higher prevalence (40.7%) than a general Asian population (17.6-23.9%) of comparable age [17][18][19][20]. The prevalence of polyps increased with age, reaching a peak at ≥60 years.…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of colonic polyps in the acromegalic population was signi cantly higher than in the Asian general population. In the nonacromegalic population, the prevalence of polyps ranged from 17.6 to 23.9% [17][18][19][20]. The prevalence of colonic polyps also varied in different acromegalic populations.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics And Associated Factors Of Colonic Polyps In Acromegaly

Peng

Zhou

et al. 2022

Preprint

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Purpose: This study investigates the clinical characteristics and the associated factors of colonic polyps in patients with acromegaly.Methods: We retrospectively reviewed clinical characteristics and colonoscopy findings of 86 acromegalic patients who received treatment between August 2015 and July 2020 at Xinqiao Hospital. We analyzed colonoscopy findings and correlation with growth hormone (GH)-secreting pituitary adenoma (GHPA) volume and hormonal/metabolic levels.Results: Our analysis revealed that the prevalence of colonic polyps in acromegalic patients was 40.7% and increased significantly with advanced age, especially ≥50 years. Multiple polyps (62.8%) and colonic polyps in the left colon (54.2%) were detected more frequently. Compared to acromegalic patients without polyps, patients with polyps displayed higher IGF-1×ULN levels (P=0.03). IGF-1 levels and GHPA volumes in patients with polyps showed increasing trends, although there were no significant differences. Meanwhile, patients with polyps in the right colon showed higher GH levels and GH nadir (GHnadir) levels in the oral glucose tolerance test (OGTT) than those with polyps in the whole colon (P=0.023 and P=0.037, respectively). GH levels were higher in patients with polyps diameter ≤5mm than those with polyps diameter >5mm (P=0.031). In addition, the univariate and multivariate logistic regression analysis exhibited GHPA volumes (OR: 1.09, 95% CI: 1.01–1.20; P = 0.039) and IGF-1×ULN Q2 levels (OR: 6.51, 95% CI: 1.20–44.60; P=0.038) were independent factors for predicting the risk of colonic polyp occurrence in acromegalic patients. A nomogram was created to evaluate the risk of colonic polyps in acromegalic patients.Conclusion: The acromegalic patients are a high prevalence population of colonic polyps. Colonic polyps in acromegaly were multiple and frequently detected in the sigmoid colon and rectum. GHPA volumes and IGF-1×ULN levels may be predictors of colonic polyp occurrence.

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Detection rate and proximal shift tendency of adenomas and serrated polyps: a retrospective study of 62,560 colonoscopies

Cited by 11 publications

References 38 publications

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia

Clinical Characteristics and Associated Factors of Colonic Polyps in Acromegaly

Clinical Characteristics And Associated Factors Of Colonic Polyps In Acromegaly

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