April 2019, the Jeneponto District Health Office be up against outbreak of the acute fever of unknown origin in Garonggong, Tuju Village, West Bangkala District, there were 70 patients with three deaths. South Sulawesi Provincial Health Service investigation found that 27 patients had fever accompanied by nausea, vomiting and headaches since the end of March 2019. Patients also felt pain in the muscles and joints so that there was a suspicion of Leptospira and or Rickettsia infection in the area. Banjarnegara Health Research and Development Unit conducted an epidemiological investigation by examining blood and kidney samples in reservoir animals in the area. Rat capturing was carried out for 2 nights to test Leptospira and Rickettsia content with PCR Methods. A total of 20 rats were caught and PCR test found one individual rat of Rattus tanezumi species positively infected by the bacteria Leptospira sp. Rickettsia examination shows that Xenopxylla cheopis fleas infested R. tanezumi positively infected with Ricketsia sp. We conclude that Garonggong, Tuju Village, West Bangkala Subdistrict, Jeneponto Regency, South Sulawesi has the potential for rat-borne disease transmission, particularly Leptospirosis and Rickettsiosis.